CRCGN010_HEPG2_24H:H16 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description chlorendic acid 4.97 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

73 genes differentially expressed following the CRCGN010_HEPG2_24H:H16 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CXCL2 chemokine (C-X-C motif) ligand 2 7.26411
CIAO3 cytosolic iron-sulfur assembly component 3 7.04935
PRR15L proline rich 15-like 6.69136
MELK maternal embryonic leucine zipper kinase 4.62775
CYCS cytochrome c, somatic 4.52583
LCN2 lipocalin 2 4.45437
UBQLN2 ubiquilin 2 4.15982
GFOD1 glucose-fructose oxidoreductase domain containing 1 3.91542
GSTZ1 glutathione S-transferase zeta 1 3.80839
CHN1 chimerin 1 3.66189
KCNK1 potassium channel, two pore domain subfamily K, member 1 3.63089
TIAM1 T-cell lymphoma invasion and metastasis 1 3.2871
GPATCH8 G patch domain containing 8 3.24383
HLA-DMA major histocompatibility complex, class II, DM alpha 3.14371
POLR2K polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa 3.12329
CARMIL1 capping protein regulator and myosin 1 linker 1 3.04024
STIMATE STIM activating enhancer 2.74607
VAV3 vav 3 guanine nucleotide exchange factor 2.69149
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 2.62366
NME2 NME/NM23 nucleoside diphosphate kinase 2 2.50601
TNIP1 TNFAIP3 interacting protein 1 2.49349
STK10 serine/threonine kinase 10 2.35788
PRRC1 proline-rich coiled-coil 1 2.21148
BCAT1 branched chain amino-acid transaminase 1, cytosolic 2.16229
HOXA10 homeobox A10 2.11398
GATA2 GATA binding protein 2 2.10592
VGLL4 vestigial-like family member 4 2.0958
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.09527
MCUR1 mitochondrial calcium uniporter regulator 1 2.0793
TEX10 testis expressed 10 2.05135
MINDY1 MINDY lysine 48 deubiquitinase 1 2.04765
CLINT1 clathrin interactor 1 2.01648

decreased expression

Symbol Name Standardized Value
TRIB3 tribbles pseudokinase 3 -10.0
OXA1L oxidase (cytochrome c) assembly 1-like -5.47598
TLCD3A TLC domain containing 3A -4.66978
LDHD lactate dehydrogenase D -3.85527
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -3.8068
WDR7 WD repeat domain 7 -3.51975
CCDC86 coiled-coil domain containing 86 -3.40666
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -3.25461
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -3.25087
ACAA1 acetyl-CoA acyltransferase 1 -3.23408
ADI1 acireductone dioxygenase 1 -3.23354
GLOD4 glyoxalase domain containing 4 -3.06527
CDC20 cell division cycle 20 -3.01025
EIF5 eukaryotic translation initiation factor 5 -2.94437
ITGB1BP1 integrin beta 1 binding protein 1 -2.92664
DNMT1 DNA (cytosine-5-)-methyltransferase 1 -2.89071
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -2.87463
KDM3A lysine (K)-specific demethylase 3A -2.85606
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -2.78591
MTFR1 mitochondrial fission regulator 1 -2.69298
PEG10 paternally expressed 10 -2.6669
TLR4 toll-like receptor 4 -2.61304
ZNF586 zinc finger protein 586 -2.5242
TRAP1 TNF receptor-associated protein 1 -2.48684
ERBB2 erb-b2 receptor tyrosine kinase 2 -2.45827
CRK v-crk avian sarcoma virus CT10 oncogene homolog -2.39397
CCNB2 cyclin B2 -2.35347
TRAPPC6A trafficking protein particle complex 6A -2.32248
MYOG myogenin (myogenic factor 4) -2.26826
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1 -2.24836
CHMP4B charged multivesicular body protein 4B -2.21815
HMG20B high mobility group 20B -2.21358
FASTKD5 FAST kinase domains 5 -2.16985
ZNF227 zinc finger protein 227 -2.10644
MYBPC2 myosin binding protein C, fast type -2.10262
ABLIM3 actin binding LIM protein family, member 3 -2.07935
ACADSB acyl-CoA dehydrogenase, short/branched chain -2.07518
FGD6 FYVE, RhoGEF and PH domain containing 6 -2.0362
RAB11FIP5 RAB11 family interacting protein 5 (class I) -2.03176
USP6NL USP6 N-terminal like -2.03039
TNNI1 troponin I type 1 (skeletal, slow) -2.00618