CRCGN010_HEPG2_24H:H19 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description etodolac 40.0 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

54 genes differentially expressed following the CRCGN010_HEPG2_24H:H19 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MAP7 microtubule-associated protein 7 7.5497
LCN2 lipocalin 2 5.60961
PPARG peroxisome proliferator-activated receptor gamma 5.59424
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 5.15608
SYNE2 spectrin repeat containing, nuclear envelope 2 4.78171
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 4.23358
STIMATE STIM activating enhancer 3.46835
CYB561 cytochrome b561 3.33376
DYNLT3 dynein, light chain, Tctex-type 3 3.13351
CYCS cytochrome c, somatic 2.70389
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.55079
FAM53C family with sequence similarity 53, member C 2.45247
BAD BCL2-associated agonist of cell death 2.37952
RALGDS ral guanine nucleotide dissociation stimulator 2.35288
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 2.31525
AXIN1 axin 1 2.29061
TNIP1 TNFAIP3 interacting protein 1 2.26552
GPER1 G protein-coupled estrogen receptor 1 2.16677
SOWAHC sosondowah ankyrin repeat domain family member C 2.11287
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6 2.09568
SLC44A4 solute carrier family 44, member 4 2.09108
NOSIP nitric oxide synthase interacting protein 2.03488
SOCS6 suppressor of cytokine signaling 6 2.02865

decreased expression

Symbol Name Standardized Value
NT5DC2 5'-nucleotidase domain containing 2 -8.81453
NUP85 nucleoporin 85kDa -5.39617
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -5.02536
TSPAN4 tetraspanin 4 -5.01626
CCNB2 cyclin B2 -4.958
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -4.95532
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -4.84467
VAT1 vesicle amine transport 1 -4.82814
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -4.00793
ITGB1BP1 integrin beta 1 binding protein 1 -3.88641
LDHD lactate dehydrogenase D -3.7223
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -3.67491
YME1L1 YME1-like 1 ATPase -3.25044
SLC35F2 solute carrier family 35, member F2 -3.19195
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -2.82955
OXA1L oxidase (cytochrome c) assembly 1-like -2.8039
MAPK13 mitogen-activated protein kinase 13 -2.69795
FGFR4 fibroblast growth factor receptor 4 -2.64456
NAT9 N-acetyltransferase 9 (GCN5-related, putative) -2.59307
SUMO4 small ubiquitin-like modifier 4 -2.47288
GNAS GNAS complex locus -2.46219
ANKRD27 ankyrin repeat domain 27 (VPS9 domain) -2.33129
NGRN neugrin, neurite outgrowth associated -2.27856
LPAR3 lysophosphatidic acid receptor 3 -2.26281
CDC25B cell division cycle 25B -2.23321
MRPS7 mitochondrial ribosomal protein S7 -2.19455
KLF8 Kruppel-like factor 8 -2.1939
SAP30BP SAP30 binding protein -2.16684
SP140 SP140 nuclear body protein -2.07953
THAP7 THAP domain containing 7 -2.04499
EXD3 exonuclease 3'-5' domain containing 3 -2.02336