CRCGN010_HEPG2_24H:H23 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description etodolac 2.5 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

39 genes differentially expressed following the CRCGN010_HEPG2_24H:H23 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
DYNLT3 dynein, light chain, Tctex-type 3 5.87235
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 5.43935
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 5.15065
CARMIL1 capping protein regulator and myosin 1 linker 1 4.95946
STIMATE STIM activating enhancer 4.62544
EVL Enah/Vasp-like 4.50129
HLA-DMA major histocompatibility complex, class II, DM alpha 3.69562
DIPK1A divergent protein kinase domain 1A 3.6879
NOSIP nitric oxide synthase interacting protein 3.58749
MAP7 microtubule-associated protein 7 3.50992
PRKCH protein kinase C, eta 3.463
UBQLN2 ubiquilin 2 3.03752
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 2.89638
MCOLN1 mucolipin 1 2.72096
NOTCH1 notch 1 2.5654
GPER1 G protein-coupled estrogen receptor 1 2.49507
EPHB2 EPH receptor B2 2.48866
SIRT3 sirtuin 3 2.27871
TNIP1 TNFAIP3 interacting protein 1 2.22885
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.127
RPA3 replication protein A3, 14kDa 2.12053
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 2.06978
LOC122526780 uncharacterized LOC122526780 2.02737

decreased expression

Symbol Name Standardized Value
CD320 CD320 molecule -5.28572
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -5.20321
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -5.1369
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -5.09
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -5.00635
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -3.30275
EIF5 eukaryotic translation initiation factor 5 -3.22993
GOLT1B golgi transport 1B -3.06696
ZNF586 zinc finger protein 586 -2.96073
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -2.89005
CCDC86 coiled-coil domain containing 86 -2.65323
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.40154
FABP5 fatty acid binding protein 5 (psoriasis-associated) -2.3698
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D -2.27952
PROS1 protein S (alpha) -2.20738
HSPB1 heat shock 27kDa protein 1 -2.10216