CRCGN010_HEPG2_24H:I07 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description acetohexamide 20.96 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

57 genes differentially expressed following the CRCGN010_HEPG2_24H:I07 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
NOTCH1 notch 1 9.32793
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 9.29421
MAMLD1 mastermind-like domain containing 1 5.05119
CHMP6 charged multivesicular body protein 6 4.79164
DENND2D DENN/MADD domain containing 2D 4.54654
MCOLN1 mucolipin 1 4.35817
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 4.27823
SFTPB surfactant protein B 4.26867
PPARG peroxisome proliferator-activated receptor gamma 4.20962
ADGRE5 adhesion G protein-coupled receptor E5 3.87626
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 3.62238
FZD7 frizzled class receptor 7 3.58626
CGRRF1 cell growth regulator with ring finger domain 1 3.45755
TREM1 triggering receptor expressed on myeloid cells 1 3.27418
TNIP1 TNFAIP3 interacting protein 1 3.21971
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) 3.16732
ABHD4 abhydrolase domain containing 4 3.08244
AXIN1 axin 1 2.79329
EVL Enah/Vasp-like 2.74302
HSPA8 heat shock 70kDa protein 8 2.72649
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 2.69672
GPATCH8 G patch domain containing 8 2.68357
DIPK1A divergent protein kinase domain 1A 2.64228
PRR15L proline rich 15-like 2.54404
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.52491
CHEK2 checkpoint kinase 2 2.41698
ZNF589 zinc finger protein 589 2.382
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 2.37766
KRT7 keratin 7, type II 2.35959
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 2.34532
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) 2.21858
KAT6A K(lysine) acetyltransferase 6A 2.19428
CHRDL1 chordin-like 1 2.18442
JADE2 jade family PHD finger 2 2.13237
CD82 CD82 molecule 2.12249
CCNF cyclin F 2.08005
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.04877

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -10.0
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -5.53136
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.89123
VAT1 vesicle amine transport 1 -4.82177
ZNF586 zinc finger protein 586 -4.56081
CCNB2 cyclin B2 -4.36696
GNAS GNAS complex locus -3.79157
BLCAP bladder cancer associated protein -3.56947
CHMP4B charged multivesicular body protein 4B -3.11297
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -2.93321
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -2.75595
HYOU1 hypoxia up-regulated 1 -2.67934
FBXL12 F-box and leucine-rich repeat protein 12 -2.50123
ETFB electron-transfer-flavoprotein, beta polypeptide -2.32798
ZMIZ1 zinc finger, MIZ-type containing 1 -2.25789
LARP7 La ribonucleoprotein domain family, member 7 -2.24317
PROS1 protein S (alpha) -2.15857
NRIP1 nuclear receptor interacting protein 1 -2.15314
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 -2.13115
CLTB clathrin, light chain B -2.11059