CRCGN010_HEPG2_24H:I08 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description acetohexamide 10.48 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

89 genes differentially expressed following the CRCGN010_HEPG2_24H:I08 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CBR3 carbonyl reductase 3 5.57181
GSTZ1 glutathione S-transferase zeta 1 5.27479
TIAM1 T-cell lymphoma invasion and metastasis 1 4.89256
EPN2 epsin 2 4.46644
LOC122526780 uncharacterized LOC122526780 4.18585
CCNF cyclin F 3.81609
MEF2C myocyte enhancer factor 2C 3.75464
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 3.61622
CXCL2 chemokine (C-X-C motif) ligand 2 3.56785
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 3.53581
EPHA3 EPH receptor A3 3.50645
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.46927
ANO1 anoctamin 1, calcium activated chloride channel 3.39438
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 3.3469
UBQLN2 ubiquilin 2 3.32689
C2CD2 C2 calcium-dependent domain containing 2 3.25497
STIMATE STIM activating enhancer 3.2406
INTS3 integrator complex subunit 3 3.15762
ADGRE5 adhesion G protein-coupled receptor E5 3.12165
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 3.10201
PNKP polynucleotide kinase 3'-phosphatase 3.06388
CHN1 chimerin 1 3.05119
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 3.04898
STK10 serine/threonine kinase 10 2.96178
SYNE2 spectrin repeat containing, nuclear envelope 2 2.9383
CIAO3 cytosolic iron-sulfur assembly component 3 2.87625
MYLK myosin light chain kinase 2.84651
LCN2 lipocalin 2 2.72162
CDC45 cell division cycle 45 2.72128
MAP7 microtubule-associated protein 7 2.55892
B4GALT6 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6 2.50888
CD200 CD200 molecule 2.41642
KDM5A lysine (K)-specific demethylase 5A 2.40941
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.3687
FIRRM FIGNL1 interacting regulator of recombination and mitosis 2.36429
CXCR4 chemokine (C-X-C motif) receptor 4 2.36231
HLA-DRA major histocompatibility complex, class II, DR alpha 2.34995
FZD7 frizzled class receptor 7 2.31115
ELP5 elongator acetyltransferase complex subunit 5 2.22197
YTHDC1 YTH domain containing 1 2.21482
H2BC12 H2B clustered histone 12 2.20075
PLSCR3 phospholipid scramblase 3 2.16414
METTL4 methyltransferase like 4 2.15768
CCL2 chemokine (C-C motif) ligand 2 2.11451
SYNM synemin, intermediate filament protein 2.11416
NAP1L2 nucleosome assembly protein 1-like 2 2.10356
KCNK1 potassium channel, two pore domain subfamily K, member 1 2.07578
SUSD5 sushi domain containing 5 2.03879
SEMA3E sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E 2.02633
RIPPLY2-CYB5R4 RIPPLY2-CYB5R4 readthrough 2.02434
USP24 ubiquitin specific peptidase 24 2.02421
MAGEA4 melanoma antigen family A4 2.0144

decreased expression

Symbol Name Standardized Value
TRIB3 tribbles pseudokinase 3 -6.98726
CCNB2 cyclin B2 -6.81709
OXA1L oxidase (cytochrome c) assembly 1-like -6.40962
ZMIZ1 zinc finger, MIZ-type containing 1 -5.68581
TM9SF3 transmembrane 9 superfamily member 3 -5.51673
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -3.63021
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -3.45397
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.3773
ITFG1 integrin alpha FG-GAP repeat containing 1 -3.34509
UGDH UDP-glucose 6-dehydrogenase -3.31224
KDM3A lysine (K)-specific demethylase 3A -3.26021
FBXL12 F-box and leucine-rich repeat protein 12 -3.2527
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -3.24556
CD320 CD320 molecule -3.11746
COG2 component of oligomeric golgi complex 2 -3.04598
CASP7 caspase 7, apoptosis-related cysteine peptidase -2.96436
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -2.94155
CHMP4B charged multivesicular body protein 4B -2.90332
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -2.85567
NR2F6 nuclear receptor subfamily 2, group F, member 6 -2.80959
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -2.688
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae) -2.60725
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) -2.56141
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) -2.47936
BECN1 beclin 1, autophagy related -2.35267
PEG10 paternally expressed 10 -2.30452
ERBB2 erb-b2 receptor tyrosine kinase 2 -2.30262
SHARPIN SHANK-associated RH domain interactor -2.26612
SNX11 sorting nexin 11 -2.24873
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) -2.20632
HS6ST1 heparan sulfate 6-O-sulfotransferase 1 -2.15043
TWF2 twinfilin actin binding protein 2 -2.13232
DMTN dematin actin binding protein -2.10923
WASHC4 WASH complex subunit 4 -2.09497
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1 -2.0824
HYOU1 hypoxia up-regulated 1 -2.03734
GNAS GNAS complex locus -2.00211