CRCGN010_HEPG2_24H:I10 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description acetohexamide 2.62 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

39 genes differentially expressed following the CRCGN010_HEPG2_24H:I10 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 6.70472
MSRA methionine sulfoxide reductase A 4.99818
CSK c-src tyrosine kinase 4.88528
PPARG peroxisome proliferator-activated receptor gamma 4.73701
PEX11A peroxisomal biogenesis factor 11 alpha 4.23734
MAP7 microtubule-associated protein 7 4.10763
PLS1 plastin 1 3.98153
JADE2 jade family PHD finger 2 3.7339
GPER1 G protein-coupled estrogen receptor 1 3.30959
NUCB2 nucleobindin 2 3.26277
DIPK1A divergent protein kinase domain 1A 3.19498
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 3.09889
GPATCH8 G patch domain containing 8 2.72313
PRR15L proline rich 15-like 2.72297
FHL5 four and a half LIM domains 5 2.65029
NOTCH1 notch 1 2.59105
CHMP6 charged multivesicular body protein 6 2.53943
NR1H2 nuclear receptor subfamily 1, group H, member 2 2.48517
CHN1 chimerin 1 2.47262
ADRB2 adrenoceptor beta 2, surface 2.41302
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 2.35582
TLR4 toll-like receptor 4 2.34982
ZNF239 zinc finger protein 239 2.34279
STIMATE STIM activating enhancer 2.34143
NXPE3 neurexophilin and PC-esterase domain family, member 3 2.02477
UFM1 ubiquitin-fold modifier 1 2.01736

decreased expression

Symbol Name Standardized Value
CCNB2 cyclin B2 -6.60081
ADI1 acireductone dioxygenase 1 -4.85432
LOC124907782 dual specificity protein phosphatase 22 -4.81301
RNF167 ring finger protein 167 -3.96077
CASP7 caspase 7, apoptosis-related cysteine peptidase -3.87885
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) -3.56243
ZMIZ1 zinc finger, MIZ-type containing 1 -3.00553
STAT1 signal transducer and activator of transcription 1, 91kDa -2.67958
ICAM5 intercellular adhesion molecule 5, telencephalin -2.26088
GOLT1B golgi transport 1B -2.15969
PLK1 polo-like kinase 1 -2.11892
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -2.03251
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -2.0046