CRCGN010_HEPG2_24H:I15 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description fenthion 5.39 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

63 genes differentially expressed following the CRCGN010_HEPG2_24H:I15 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CXCL2 chemokine (C-X-C motif) ligand 2 5.35416
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.52485
CHN1 chimerin 1 4.38281
RPL39L ribosomal protein L39-like 4.28182
DIPK1A divergent protein kinase domain 1A 4.21265
MAP7 microtubule-associated protein 7 3.63503
CBR3 carbonyl reductase 3 3.44503
CCDC92 coiled-coil domain containing 92 2.93465
TSPAN6 tetraspanin 6 2.77149
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 2.75361
COPS7A COP9 signalosome subunit 7A 2.60919
MCUR1 mitochondrial calcium uniporter regulator 1 2.56528
PLSCR3 phospholipid scramblase 3 2.55865
RFC5 replication factor C (activator 1) 5, 36.5kDa 2.52553
CASP2 caspase 2, apoptosis-related cysteine peptidase 2.46895
HLA-DRA major histocompatibility complex, class II, DR alpha 2.4632
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 2.41024
CIAO3 cytosolic iron-sulfur assembly component 3 2.35914
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 2.23883
HEY2 hes-related family bHLH transcription factor with YRPW motif 2 2.18937
PAFAH1B2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa) 2.14562
NOSIP nitric oxide synthase interacting protein 2.08688
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 2.07864
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 2.06774
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide 2.06763
CASP6 caspase 6, apoptosis-related cysteine peptidase 2.05025

decreased expression

Symbol Name Standardized Value
CCNB2 cyclin B2 -9.36245
OXA1L oxidase (cytochrome c) assembly 1-like -6.27582
GNAS GNAS complex locus -5.51621
CASP7 caspase 7, apoptosis-related cysteine peptidase -5.06
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -4.70959
RNF167 ring finger protein 167 -4.21174
FAIM Fas apoptotic inhibitory molecule -4.00671
WDR7 WD repeat domain 7 -3.84795
FGFR4 fibroblast growth factor receptor 4 -3.77759
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -3.72284
ITFG1 integrin alpha FG-GAP repeat containing 1 -3.52055
CCDC86 coiled-coil domain containing 86 -3.50485
C2CD5 C2 calcium-dependent domain containing 5 -3.31093
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -3.27343
MRPS2 mitochondrial ribosomal protein S2 -3.24044
DNMT1 DNA (cytosine-5-)-methyltransferase 1 -3.08051
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.92486
TRIB3 tribbles pseudokinase 3 -2.91735
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -2.85157
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -2.73303
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -2.70636
VDAC1 voltage-dependent anion channel 1 -2.69476
XPO7 exportin 7 -2.63194
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -2.63006
CHMP4B charged multivesicular body protein 4B -2.49144
TXNDC9 thioredoxin domain containing 9 -2.4899
CRELD2 cysteine-rich with EGF-like domains 2 -2.30442
THAP11 THAP domain containing 11 -2.25539
DCX doublecortin -2.22758
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.18202
A2M alpha-2-macroglobulin -2.16417
ZNF146 zinc finger protein 146 -2.11186
NLRP4 NLR family, pyrin domain containing 4 -2.06666
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -2.0507
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -2.01864
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 -2.00657
NPIPB5 nuclear pore complex interacting protein family, member B5 -2.00034