CRCGN010_HEPG2_24H:I16 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description fenthion 2.69 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

86 genes differentially expressed following the CRCGN010_HEPG2_24H:I16 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
JADE2 jade family PHD finger 2 4.91174
CSK c-src tyrosine kinase 4.85759
ABHD6 abhydrolase domain containing 6 4.28351
AMDHD2 amidohydrolase domain containing 2 4.09747
RPP38 ribonuclease P/MRP 38kDa subunit 4.05744
CBR3 carbonyl reductase 3 4.04189
CXCL2 chemokine (C-X-C motif) ligand 2 4.00606
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 3.74239
E2F2 E2F transcription factor 2 3.42271
NR1H2 nuclear receptor subfamily 1, group H, member 2 3.2277
CIAO3 cytosolic iron-sulfur assembly component 3 3.19409
VAV3 vav 3 guanine nucleotide exchange factor 3.15516
EAPP E2F-associated phosphoprotein 2.91132
CTSL cathepsin L 2.8697
EMP3 epithelial membrane protein 3 2.84893
KCNK1 potassium channel, two pore domain subfamily K, member 1 2.80354
CARMIL1 capping protein regulator and myosin 1 linker 1 2.751
NOSIP nitric oxide synthase interacting protein 2.73845
HLA-DMA major histocompatibility complex, class II, DM alpha 2.70759
ANO1 anoctamin 1, calcium activated chloride channel 2.58322
DYNLT3 dynein, light chain, Tctex-type 3 2.4973
PIH1D1 PIH1 domain containing 1 2.45539
CYTH1 cytohesin 1 2.40561
EPHA3 EPH receptor A3 2.3738
PGAM4 phosphoglycerate mutase family member 4 2.36741
HLF hepatic leukemia factor 2.36162
SIRT3 sirtuin 3 2.31227
EPN2 epsin 2 2.28688
GATA3 GATA binding protein 3 2.27877
INTS12 integrator complex subunit 12 2.19665
GABARAPL2 GABA(A) receptor-associated protein-like 2 2.17251
KLF2 Kruppel-like factor 2 2.12991
TSC22D4 TSC22 domain family, member 4 2.11739
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.08201
PIPOX pipecolic acid oxidase 2.06612
CRLF3 cytokine receptor-like factor 3 2.05472
PDLIM4 PDZ and LIM domain 4 2.02722
HLA-DRB3 major histocompatibility complex, class II, DR beta 3 2.02152
SLC27A5 solute carrier family 27 (fatty acid transporter), member 5 2.01966
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa 2.00458
TREM1 triggering receptor expressed on myeloid cells 1 2.00084

decreased expression

Symbol Name Standardized Value
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -6.34597
CASP7 caspase 7, apoptosis-related cysteine peptidase -4.75101
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -4.19588
NGRN neugrin, neurite outgrowth associated -3.96497
FBXL12 F-box and leucine-rich repeat protein 12 -3.95789
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -3.88473
CCNB2 cyclin B2 -3.72306
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -3.67358
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -3.62833
CDC20 cell division cycle 20 -3.6247
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.60855
GNAS GNAS complex locus -3.48033
C2CD5 C2 calcium-dependent domain containing 5 -3.41682
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 -3.30558
CTSD cathepsin D -3.26473
CDC25B cell division cycle 25B -2.9461
CHEK1 checkpoint kinase 1 -2.92031
PDHX pyruvate dehydrogenase complex, component X -2.75645
ITGB1BP1 integrin beta 1 binding protein 1 -2.73176
NOTCH1 notch 1 -2.66607
RAI14 retinoic acid induced 14 -2.55607
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked -2.53913
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group) -2.4985
ZMIZ1 zinc finger, MIZ-type containing 1 -2.42733
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.41929
EED embryonic ectoderm development -2.3338
PTPRK protein tyrosine phosphatase, receptor type, K -2.30562
DNM1L dynamin 1-like -2.29709
FGF18 fibroblast growth factor 18 -2.28912
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3 -2.27576
ST18 suppression of tumorigenicity 18, zinc finger -2.2641
KRT20 keratin 20, type I -2.26171
CERK ceramide kinase -2.25961
CLTB clathrin, light chain B -2.22475
APOBR apolipoprotein B receptor -2.187
GADD45A growth arrest and DNA-damage-inducible, alpha -2.17296
FNDC3B fibronectin type III domain containing 3B -2.15593
TXNDC9 thioredoxin domain containing 9 -2.15313
NEUROD1 neuronal differentiation 1 -2.13744
GDF15 growth differentiation factor 15 -2.08776
PPP1R17 protein phosphatase 1, regulatory subunit 17 -2.08315
PCNA proliferating cell nuclear antigen -2.05703
CDC50B cell division cycle 50 P4-ATPase accessory subunit B -2.03207
MISP mitotic spindle positioning -2.00672
INSM1 insulinoma-associated 1 -2.00495