CRCGN010_HEPG2_24H:I17 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description fenthion 1.35 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

108 genes differentially expressed following the CRCGN010_HEPG2_24H:I17 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ADRB2 adrenoceptor beta 2, surface 10.0
CIAO3 cytosolic iron-sulfur assembly component 3 7.1371
DYNLT3 dynein, light chain, Tctex-type 3 5.70773
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 4.66763
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 4.22762
MNAT1 MNAT CDK-activating kinase assembly factor 1 3.6613
ADGRE5 adhesion G protein-coupled receptor E5 3.58408
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 3.56205
KIFBP kinesin family binding protein 3.52901
NMU neuromedin U 3.4226
CSK c-src tyrosine kinase 3.23826
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 3.20066
PNKP polynucleotide kinase 3'-phosphatase 3.1951
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 3.10198
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 2.95436
CASP2 caspase 2, apoptosis-related cysteine peptidase 2.84293
LCN2 lipocalin 2 2.81219
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 2.73345
SSBP2 single-stranded DNA binding protein 2 2.51916
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 2.42038
MAN2B2 mannosidase, alpha, class 2B, member 2 2.34746
SFTPB surfactant protein B 2.34501
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.33648
CCL2 chemokine (C-C motif) ligand 2 2.32387
FOXD1 forkhead box D1 2.32369
GARRE1 granule associated Rac and RHOG effector 1 2.26349
NOSIP nitric oxide synthase interacting protein 2.23188
SHB Src homology 2 domain containing adaptor protein B 2.12749
HSPA8 heat shock 70kDa protein 8 2.10135
FRG1 FSHD region gene 1 2.04319
RMDN1 regulator of microtubule dynamics 1 2.02693

decreased expression

Symbol Name Standardized Value
OXA1L oxidase (cytochrome c) assembly 1-like -6.82353
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -6.75436
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -6.57198
PCNA proliferating cell nuclear antigen -5.90381
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.30832
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase -3.95632
LDHD lactate dehydrogenase D -3.89993
UGDH UDP-glucose 6-dehydrogenase -3.8242
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -3.51711
LOC124907782 dual specificity protein phosphatase 22 -3.41689
B4GAT1 beta-1,4-glucuronyltransferase 1 -3.12671
VAT1 vesicle amine transport 1 -3.00923
ZMIZ1 zinc finger, MIZ-type containing 1 -2.94582
RAI14 retinoic acid induced 14 -2.92432
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -2.90673
YME1L1 YME1-like 1 ATPase -2.89504
DENND2D DENN/MADD domain containing 2D -2.89092
GOLGA4 golgin A4 -2.8155
MAPK13 mitogen-activated protein kinase 13 -2.80541
THAP11 THAP domain containing 11 -2.79018
PEG10 paternally expressed 10 -2.75761
UCP1 uncoupling protein 1 (mitochondrial, proton carrier) -2.7142
GUCA2B guanylate cyclase activator 2B (uroguanylin) -2.67209
SLC35F2 solute carrier family 35, member F2 -2.62397
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -2.61066
HEATR1 HEAT repeat containing 1 -2.61025
ZNF586 zinc finger protein 586 -2.59704
TSNAXIP1 translin-associated factor X interacting protein 1 -2.59519
PHKG1 phosphorylase kinase, gamma 1 (muscle) -2.58369
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -2.54093
QRICH1 glutamine-rich 1 -2.53436
FCGBP Fc fragment of IgG binding protein -2.52052
PSKH1 protein serine kinase H1 -2.42851
GSG1 germ cell associated 1 -2.38832
LY6H lymphocyte antigen 6 complex, locus H -2.38638
MRPS16 mitochondrial ribosomal protein S16 -2.36957
ERBB2 erb-b2 receptor tyrosine kinase 2 -2.36018
PLIN2 perilipin 2 -2.34473
PTPRK protein tyrosine phosphatase, receptor type, K -2.33257
EDA2R ectodysplasin A2 receptor -2.30367
KDM3A lysine (K)-specific demethylase 3A -2.30237
SCN5A sodium channel, voltage gated, type V alpha subunit -2.28557
TULP1 tubby like protein 1 -2.26812
ZNF208 zinc finger protein 208 -2.24275
GZMM granzyme M (lymphocyte met-ase 1) -2.21938
SSX5 synovial sarcoma, X breakpoint 5 -2.21637
SALL2 spalt-like transcription factor 2 -2.20238
ACTL7A actin-like 7A -2.19034
ATOH1 atonal homolog 1 (Drosophila) -2.17251
MUC2 mucin 2, oligomeric mucus/gel-forming -2.16459
OR7C1 olfactory receptor, family 7, subfamily C, member 1 -2.15205
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.13801
ANKRD40CL ANKRD40 C-terminal like -2.12852
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2 -2.12279
ADGRG6 adhesion G protein-coupled receptor G6 -2.10242
AMELY amelogenin, Y-linked -2.09632
PACRG PARK2 co-regulated -2.08533
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme -2.07693
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 -2.07453
PLEKHA6 pleckstrin homology domain containing, family A member 6 -2.07283
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4 -2.07214
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1 -2.06356
NEUROD6 neuronal differentiation 6 -2.06286
EFNA1 ephrin-A1 -2.05961
PYY peptide YY -2.05205
GUCY2D guanylate cyclase 2D, membrane (retina-specific) -2.0497
HMHB1 histocompatibility (minor) HB-1 -2.04507
ODF1 outer dense fiber of sperm tails 1 -2.04419
VASH1 vasohibin 1 -2.04322
GFI1B growth factor independent 1B transcription repressor -2.04057
NKX3-2 NK3 homeobox 2 -2.03627
WASHC4 WASH complex subunit 4 -2.03206
TMEM121 transmembrane protein 121 -2.02923
CTSD cathepsin D -2.02238
EFNA4 ephrin-A4 -2.02106
KLK5 kallikrein-related peptidase 5 -2.01611
TARBP1 TAR (HIV-1) RNA binding protein 1 -2.00466