CRCGN010_HEPG2_24H:I19 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description ciprofibrate 21.38 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

46 genes differentially expressed following the CRCGN010_HEPG2_24H:I19 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MAP7 microtubule-associated protein 7 8.41646
SNAP25 synaptosomal-associated protein, 25kDa 6.02746
CSK c-src tyrosine kinase 4.39759
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.25581
LCN2 lipocalin 2 4.04543
HLA-DMA major histocompatibility complex, class II, DM alpha 3.97091
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 3.87261
CCL2 chemokine (C-C motif) ligand 2 3.8037
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 3.73926
SLC75A1 solute carrier family 75 member 1 3.5851
E2F2 E2F transcription factor 2 3.44816
INSIG1 insulin induced gene 1 3.35064
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 3.26825
TRAM2 translocation associated membrane protein 2 3.18798
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 3.15459
EDN1 endothelin 1 3.14184
MEST mesoderm specific transcript 3.03044
CGRRF1 cell growth regulator with ring finger domain 1 2.97145
CYCS cytochrome c, somatic 2.68127
FPGS folylpolyglutamate synthase 2.49793
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.45342
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 2.18003
OXCT1 3-oxoacid CoA transferase 1 2.12577
ANKRD10 ankyrin repeat domain 10 2.03995
BIRC2 baculoviral IAP repeat containing 2 2.03139
TIAM1 T-cell lymphoma invasion and metastasis 1 2.02276
SLC25A46 solute carrier family 25, member 46 2.01633

decreased expression

Symbol Name Standardized Value
CCNB2 cyclin B2 -5.61352
CD320 CD320 molecule -4.41552
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -4.35557
SNX11 sorting nexin 11 -3.34578
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -3.32844
TSEN2 TSEN2 tRNA splicing endonuclease subunit -3.29332
CCDC86 coiled-coil domain containing 86 -3.05965
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -2.60327
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -2.44348
FBXL12 F-box and leucine-rich repeat protein 12 -2.43332
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 -2.38866
CASP7 caspase 7, apoptosis-related cysteine peptidase -2.386
STX4 syntaxin 4 -2.30161
GNAS GNAS complex locus -2.2832
TLR4 toll-like receptor 4 -2.2224
ARID5B AT rich interactive domain 5B (MRF1-like) -2.10394
WDCP WD repeat and coiled coil containing -2.08649
LDHD lactate dehydrogenase D -2.05073
TRAP1 TNF receptor-associated protein 1 -2.02135