CRCGN010_HEPG2_24H:I21 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description ciprofibrate 5.34 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

95 genes differentially expressed following the CRCGN010_HEPG2_24H:I21 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 10.0
ABHD4 abhydrolase domain containing 4 8.51982
CDPF1 cysteine-rich, DPF motif domain containing 1 6.89043
PPARG peroxisome proliferator-activated receptor gamma 4.93636
UBQLN2 ubiquilin 2 4.83911
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 4.79081
STIMATE STIM activating enhancer 4.71502
CCNF cyclin F 4.6813
CXCL2 chemokine (C-X-C motif) ligand 2 4.55329
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 4.26725
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) 4.24453
E2F2 E2F transcription factor 2 4.07738
FZD7 frizzled class receptor 7 3.91271
RAB21 RAB21, member RAS oncogene family 3.7867
SFTPB surfactant protein B 3.61006
TREM1 triggering receptor expressed on myeloid cells 1 3.56432
HLA-DMA major histocompatibility complex, class II, DM alpha 3.35717
HLA-DRA major histocompatibility complex, class II, DR alpha 3.33136
POLR2K polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa 3.2455
PLSCR1 phospholipid scramblase 1 3.1861
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 3.17958
GPATCH8 G patch domain containing 8 3.14976
CEMIP2 cell migration inducing hyaluronidase 2 3.03958
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 2.89474
SNX7 sorting nexin 7 2.81964
PRR15L proline rich 15-like 2.6827
ANO10 anoctamin 10 2.64244
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 2.61532
TIAM1 T-cell lymphoma invasion and metastasis 1 2.6069
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.59535
EVL Enah/Vasp-like 2.56451
CYCS cytochrome c, somatic 2.52144
POLG2 polymerase (DNA directed), gamma 2, accessory subunit 2.50808
FAM222B family with sequence similarity 222, member B 2.48794
NOSIP nitric oxide synthase interacting protein 2.48261
ZNF589 zinc finger protein 589 2.47048
MEST mesoderm specific transcript 2.46209
SS18L2 synovial sarcoma translocation gene on chromosome 18-like 2 2.42565
SMIM40 small integral membrane protein 40 2.35656
ARID3A AT rich interactive domain 3A (BRIGHT-like) 2.35015
MEAF6 MYST/Esa1-associated factor 6 2.34574
PIH1D1 PIH1 domain containing 1 2.33213
GRWD1 glutamate-rich WD repeat containing 1 2.31042
SIRT3 sirtuin 3 2.25525
CHCHD7 coiled-coil-helix-coiled-coil-helix domain containing 7 2.21232
WIPF2 WAS/WASL interacting protein family, member 2 2.20582
MRPL17 mitochondrial ribosomal protein L17 2.18013
MLF1 myeloid leukemia factor 1 2.16678
CDK19 cyclin-dependent kinase 19 2.14741
MYL7 myosin, light chain 7, regulatory 2.13943
JADE2 jade family PHD finger 2 2.08215
LPCAT3 lysophosphatidylcholine acyltransferase 3 2.0639
KRT76 keratin 76, type II 2.04647
RAP1A RAP1A, member of RAS oncogene family 2.03754
SMCO4 single-pass membrane protein with coiled-coil domains 4 2.03672
CD81 CD81 molecule 2.03488
HMOX1 heme oxygenase 1 2.02751
NEIL1 nei endonuclease VIII-like 1 (E. coli) 2.0245
GAPDHS glyceraldehyde-3-phosphate dehydrogenase, spermatogenic 2.02111
CCDC30 coiled-coil domain containing 30 2.00964

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -9.47698
TM9SF3 transmembrane 9 superfamily member 3 -5.30132
UGDH UDP-glucose 6-dehydrogenase -5.2701
CD320 CD320 molecule -4.8406
ZW10 zw10 kinetochore protein -4.70608
RNF167 ring finger protein 167 -4.67225
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -4.63317
PLK1 polo-like kinase 1 -4.24369
ZNF586 zinc finger protein 586 -4.23341
OXA1L oxidase (cytochrome c) assembly 1-like -4.08983
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -3.90158
FGFR4 fibroblast growth factor receptor 4 -3.61554
MAPK13 mitogen-activated protein kinase 13 -3.35696
HEATR1 HEAT repeat containing 1 -3.0711
TIMELESS timeless circadian clock -2.85513
ERC2 ELKS/RAB6-interacting/CAST family member 2 -2.85015
KIF14 kinesin family member 14 -2.60578
CD58 CD58 molecule -2.53916
FOS FBJ murine osteosarcoma viral oncogene homolog -2.50624
DPY19L4 dpy-19-like 4 (C. elegans) -2.39728
MAP2K5 mitogen-activated protein kinase kinase 5 -2.32791
PPWD1 peptidylprolyl isomerase domain and WD repeat containing 1 -2.24254
KDELR1 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 -2.23545
SMC3 structural maintenance of chromosomes 3 -2.22528
WDR3 WD repeat domain 3 -2.21267
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 -2.17791
NRCAM neuronal cell adhesion molecule -2.17542
PRPF4 pre-mRNA processing factor 4 -2.17189
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.14568
HMG20B high mobility group 20B -2.14054
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast) -2.11484
TENT4A terminal nucleotidyltransferase 4A -2.108
SH2D2A SH2 domain containing 2A -2.05765
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) -2.01426
RARRES2 retinoic acid receptor responder (tazarotene induced) 2 -2.01345