CRCGN010_HEPG2_24H:I22 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description ciprofibrate 2.67 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

89 genes differentially expressed following the CRCGN010_HEPG2_24H:I22 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PRR15L proline rich 15-like 6.51353
MAP7 microtubule-associated protein 7 6.3584
UBQLN2 ubiquilin 2 5.99607
CHN1 chimerin 1 5.47847
AMDHD2 amidohydrolase domain containing 2 5.39124
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 5.04086
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 4.3098
BACE2 beta-site APP-cleaving enzyme 2 4.16967
PPARG peroxisome proliferator-activated receptor gamma 3.88656
LYN LYN proto-oncogene, Src family tyrosine kinase 3.82435
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 3.81993
EPN2 epsin 2 3.54332
HLA-DMA major histocompatibility complex, class II, DM alpha 3.51338
DYNLT3 dynein, light chain, Tctex-type 3 3.37112
RRAGA Ras-related GTP binding A 3.26779
PFKL phosphofructokinase, liver 3.08721
GPATCH8 G patch domain containing 8 2.99285
DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2 2.98091
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.92937
TIAM1 T-cell lymphoma invasion and metastasis 1 2.87745
GPER1 G protein-coupled estrogen receptor 1 2.86051
PWP2 PWP2 periodic tryptophan protein homolog (yeast) 2.8307
SFTPB surfactant protein B 2.79395
DIPK1A divergent protein kinase domain 1A 2.78489
PRKCH protein kinase C, eta 2.77993
PMM2 phosphomannomutase 2 2.76928
GATA2 GATA binding protein 2 2.72764
HLA-DRA major histocompatibility complex, class II, DR alpha 2.69658
BPHL biphenyl hydrolase-like (serine hydrolase) 2.62582
RXYLT1 ribitol xylosyltransferase 1 2.52253
TSPAN6 tetraspanin 6 2.39939
ZNF589 zinc finger protein 589 2.3525
MAST2 microtubule associated serine/threonine kinase 2 2.31315
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 2.30816
TFB1M transcription factor B1, mitochondrial 2.29566
CBR3 carbonyl reductase 3 2.28993
PI15 peptidase inhibitor 15 2.28159
MYO19 myosin XIX 2.27253
PTCD2 pentatricopeptide repeat domain 2 2.24002
LOC122526780 uncharacterized LOC122526780 2.19526
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.15541
TCFL5 transcription factor-like 5 (basic helix-loop-helix) 2.15022
KLHL9 kelch-like family member 9 2.11483
NEIL3 nei endonuclease VIII-like 3 (E. coli) 2.0892
IVL involucrin 2.08664
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha 2.03584
CHAF1B chromatin assembly factor 1, subunit B (p60) 2.0225
B3GNT4 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4 2.00446
BARX2 BARX homeobox 2 2.00141

decreased expression

Symbol Name Standardized Value
CDC20 cell division cycle 20 -8.04318
ZNF586 zinc finger protein 586 -8.04295
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -7.69795
GNAS GNAS complex locus -6.09933
LDHD lactate dehydrogenase D -5.96062
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -5.75817
CCNB2 cyclin B2 -5.17541
ADI1 acireductone dioxygenase 1 -5.03
VDAC1 voltage-dependent anion channel 1 -4.81321
RPIA ribose 5-phosphate isomerase A -4.40015
ZMIZ1 zinc finger, MIZ-type containing 1 -4.14804
COG7 component of oligomeric golgi complex 7 -4.13246
PCCB propionyl CoA carboxylase, beta polypeptide -4.02182
ANKRD10 ankyrin repeat domain 10 -3.99823
PCNA proliferating cell nuclear antigen -3.92449
TLR4 toll-like receptor 4 -3.73282
NRIP1 nuclear receptor interacting protein 1 -3.68185
ARID5B AT rich interactive domain 5B (MRF1-like) -3.58925
FASTKD5 FAST kinase domains 5 -3.30337
RNF167 ring finger protein 167 -2.82515
MAPK13 mitogen-activated protein kinase 13 -2.82301
CAB39 calcium binding protein 39 -2.77311
CD58 CD58 molecule -2.7421
HSPBP1 HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1 -2.39082
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -2.38882
NGRN neugrin, neurite outgrowth associated -2.30578
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase -2.30467
STOM stomatin -2.2993
PSTPIP2 proline-serine-threonine phosphatase interacting protein 2 -2.29351
ZNF134 zinc finger protein 134 -2.29233
TYW2 tRNA wybutosine-synthesizing protein 2 -2.17992
DECR2 2,4-dienoyl CoA reductase 2, peroxisomal -2.17663
GMPR guanosine monophosphate reductase -2.16546
ZNF611 zinc finger protein 611 -2.14309
USP36 ubiquitin specific peptidase 36 -2.13166
TRMT2B tRNA methyltransferase 2 homolog B (S. cerevisiae) -2.10829
MT2A metallothionein 2A -2.08952
SKIL SKI-like proto-oncogene -2.06545
RNF125 ring finger protein 125, E3 ubiquitin protein ligase -2.00701
BUD23 BUD23 rRNA methyltransferase and ribosome maturation factor -2.00549