CRCGN010_HEPG2_24H:I24 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description ciprofibrate 0.67 um perturbation at 24 h in HEPG2 (Carcinogenome)
Similar Terms
Downloads & Tools

Genes

62 genes differentially expressed following the CRCGN010_HEPG2_24H:I24 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
LCN2 lipocalin 2 5.79874
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 5.71252
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 4.95052
STK10 serine/threonine kinase 10 4.45366
PLSCR1 phospholipid scramblase 1 4.38249
CXCL2 chemokine (C-X-C motif) ligand 2 4.21468
CEMIP2 cell migration inducing hyaluronidase 2 3.31232
CRTAP cartilage associated protein 3.26137
STXBP2 syntaxin binding protein 2 3.16703
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 3.12128
HLA-DMA major histocompatibility complex, class II, DM alpha 3.07332
SCRN1 secernin 1 2.97856
MCUR1 mitochondrial calcium uniporter regulator 1 2.47147
KDM5D lysine (K)-specific demethylase 5D 2.44545
TRAK2 trafficking protein, kinesin binding 2 2.43375
COPS7B COP9 signalosome subunit 7B 2.39159
CHODL chondrolectin 2.31529
CHN1 chimerin 1 2.1917
RPA3 replication protein A3, 14kDa 2.11987
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 2.09424
CCL20 chemokine (C-C motif) ligand 20 2.0628
ENY2 enhancer of yellow 2 homolog (Drosophila) 2.04378
DCAF6 DDB1 and CUL4 associated factor 6 2.00743

decreased expression

Symbol Name Standardized Value
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -8.15428
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -5.38739
FASTKD5 FAST kinase domains 5 -5.31128
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit -5.24789
MRPS2 mitochondrial ribosomal protein S2 -4.87572
PLK1 polo-like kinase 1 -4.85646
CCNB1 cyclin B1 -4.84029
ISOC1 isochorismatase domain containing 1 -4.7981
DUSP6 dual specificity phosphatase 6 -4.71424
LAP3 leucine aminopeptidase 3 -4.576
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.4226
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -4.26425
LDHD lactate dehydrogenase D -4.03468
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -3.64283
NGRN neugrin, neurite outgrowth associated -3.59037
WDR7 WD repeat domain 7 -3.52417
RAI14 retinoic acid induced 14 -3.46759
TLR4 toll-like receptor 4 -3.38341
ZNF586 zinc finger protein 586 -3.19734
MAP2K5 mitogen-activated protein kinase kinase 5 -3.1384
GOLT1B golgi transport 1B -3.05709
HMG20B high mobility group 20B -2.82888
NR2F6 nuclear receptor subfamily 2, group F, member 6 -2.53241
ADI1 acireductone dioxygenase 1 -2.5116
PDHX pyruvate dehydrogenase complex, component X -2.31785
SCN8A sodium channel, voltage gated, type VIII alpha subunit -2.29185
PRPF4 pre-mRNA processing factor 4 -2.22311
GPR39 G protein-coupled receptor 39 -2.20729
PRICKLE3 prickle homolog 3 (Drosophila) -2.19211
ITGB1BP1 integrin beta 1 binding protein 1 -2.16768
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -2.16571
OXA1L oxidase (cytochrome c) assembly 1-like -2.12589
ZBTB5 zinc finger and BTB domain containing 5 -2.10069
TTC21B tetratricopeptide repeat domain 21B -2.09502
HPS6 Hermansky-Pudlak syndrome 6 -2.09077
NRIP1 nuclear receptor interacting protein 1 -2.08163
CYP4A11 cytochrome P450, family 4, subfamily A, polypeptide 11 -2.03185
APOL3 apolipoprotein L, 3 -2.00497
CDC25B cell division cycle 25B -2.00148