| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | 2-methyl-2-[4-(1,2,3,4-tetrahydro-1-naphthalenyl)phenoxy]propanoic acid 10.63 um perturbation at 24 h in HEPG2 (Carcinogenome) |
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70 genes differentially expressed following the CRCGN010_HEPG2_24H:J02 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SLC27A3 | solute carrier family 27 (fatty acid transporter), member 3 | 8.22674 |
| MAP7 | microtubule-associated protein 7 | 6.71191 |
| CIAO3 | cytosolic iron-sulfur assembly component 3 | 6.64746 |
| ABHD6 | abhydrolase domain containing 6 | 4.68032 |
| MEST | mesoderm specific transcript | 4.50068 |
| NUDT9 | nudix (nucleoside diphosphate linked moiety X)-type motif 9 | 4.48718 |
| MMP2 | matrix metallopeptidase 2 | 4.39169 |
| CCL2 | chemokine (C-C motif) ligand 2 | 4.28246 |
| TENT4A | terminal nucleotidyltransferase 4A | 4.2467 |
| CHN1 | chimerin 1 | 3.84177 |
| SQOR | sulfide quinone oxidoreductase | 3.75818 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 3.74922 |
| RRS1 | RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) | 3.68728 |
| MYLK | myosin light chain kinase | 3.47222 |
| CSK | c-src tyrosine kinase | 3.31957 |
| NR1H2 | nuclear receptor subfamily 1, group H, member 2 | 3.29777 |
| SFTPB | surfactant protein B | 3.2773 |
| IKBKE | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon | 3.01377 |
| PPARG | peroxisome proliferator-activated receptor gamma | 2.71802 |
| UBQLN2 | ubiquilin 2 | 2.61733 |
| PACSIN3 | protein kinase C and casein kinase substrate in neurons 3 | 2.50576 |
| H2BC21 | H2B clustered histone 21 | 2.48945 |
| HLA-DMA | major histocompatibility complex, class II, DM alpha | 2.44332 |
| PLA2G4A | phospholipase A2, group IVA (cytosolic, calcium-dependent) | 2.40937 |
| NIT1 | nitrilase 1 | 2.40918 |
| MOB3B | MOB kinase activator 3B | 2.33186 |
| ANTKMT | adenine nucleotide translocase lysine methyltransferase | 2.30621 |
| MBOAT7 | membrane bound O-acyltransferase domain containing 7 | 2.24105 |
| CD40 | CD40 molecule, TNF receptor superfamily member 5 | 2.2226 |
| AMDHD2 | amidohydrolase domain containing 2 | 2.21887 |
| RPUSD2 | RNA pseudouridylate synthase domain containing 2 | 2.20131 |
| GEMIN8 | gem (nuclear organelle) associated protein 8 | 2.18598 |
| ANKRD40CL | ANKRD40 C-terminal like | 2.18172 |
| RPS6KA1 | ribosomal protein S6 kinase, 90kDa, polypeptide 1 | 2.14299 |
| PTK2 | protein tyrosine kinase 2 | 2.13599 |
| DFFA | DNA fragmentation factor, 45kDa, alpha polypeptide | 2.07554 |
| FPR3 | formyl peptide receptor 3 | 2.05316 |
| ANKRD34C | ankyrin repeat domain 34C | 2.04609 |
| Symbol | Name | Standardized Value |
|---|---|---|
| LDHD | lactate dehydrogenase D | -7.72457 |
| RNF167 | ring finger protein 167 | -4.47125 |
| YTHDF1 | YTH N(6)-methyladenosine RNA binding protein 1 | -4.05754 |
| PCNA | proliferating cell nuclear antigen | -3.68075 |
| TARBP1 | TAR (HIV-1) RNA binding protein 1 | -3.57988 |
| PROS1 | protein S (alpha) | -3.4932 |
| SLC35F2 | solute carrier family 35, member F2 | -3.37715 |
| ZNF586 | zinc finger protein 586 | -3.36645 |
| IARS2 | isoleucyl-tRNA synthetase 2, mitochondrial | -3.24176 |
| CHIC2 | cysteine-rich hydrophobic domain 2 | -3.21601 |
| NT5DC2 | 5'-nucleotidase domain containing 2 | -3.20177 |
| GNAS | GNAS complex locus | -2.82227 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -2.7565 |
| HSPB1 | heat shock 27kDa protein 1 | -2.75561 |
| MNAT1 | MNAT CDK-activating kinase assembly factor 1 | -2.593 |
| TM9SF3 | transmembrane 9 superfamily member 3 | -2.48523 |
| MTA1 | metastasis associated 1 | -2.4646 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -2.46222 |
| TATDN2 | TatD DNase domain containing 2 | -2.42068 |
| MRPS2 | mitochondrial ribosomal protein S2 | -2.30964 |
| ETFB | electron-transfer-flavoprotein, beta polypeptide | -2.28703 |
| TCERG1 | transcription elongation regulator 1 | -2.23419 |
| PPY | pancreatic polypeptide | -2.19765 |
| DNTTIP2 | deoxynucleotidyltransferase, terminal, interacting protein 2 | -2.17463 |
| TCEAL4 | transcription elongation factor A (SII)-like 4 | -2.16363 |
| CBR1 | carbonyl reductase 1 | -2.14658 |
| CRELD2 | cysteine-rich with EGF-like domains 2 | -2.12988 |
| TERF2IP | telomeric repeat binding factor 2, interacting protein | -2.10676 |
| PECR | peroxisomal trans-2-enoyl-CoA reductase | -2.10676 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | -2.10278 |
| SIPA1 | signal-induced proliferation-associated 1 | -2.04758 |
| ACLY | ATP citrate lyase | -2.00574 |
