CRCGN010_HEPG2_24H:J03 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2-methyl-2-[4-(1,2,3,4-tetrahydro-1-naphthalenyl)phenoxy]propanoic acid 5.32 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

230 genes differentially expressed following the CRCGN010_HEPG2_24H:J03 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MEST mesoderm specific transcript 6.8933
AMDHD2 amidohydrolase domain containing 2 6.04018
ATP11B ATPase, class VI, type 11B 5.99631
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 5.71396
CCL2 chemokine (C-C motif) ligand 2 5.58658
PTPN6 protein tyrosine phosphatase, non-receptor type 6 5.12141
CIAO3 cytosolic iron-sulfur assembly component 3 4.97225
C2CD2 C2 calcium-dependent domain containing 2 4.94783
STIMATE STIM activating enhancer 4.89594
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 4.85476
HEBP1 heme binding protein 1 4.7552
FCHO1 FCH domain only 1 4.61679
DHX29 DEAH (Asp-Glu-Ala-His) box polypeptide 29 4.55342
CCDC92 coiled-coil domain containing 92 4.43999
INTS3 integrator complex subunit 3 4.42791
WDR7 WD repeat domain 7 4.42501
EAPP E2F-associated phosphoprotein 4.3465
CCDC85B coiled-coil domain containing 85B 4.33831
TREM1 triggering receptor expressed on myeloid cells 1 4.30129
SNAP25 synaptosomal-associated protein, 25kDa 4.29739
TESK1 testis-specific kinase 1 4.23909
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 4.2146
LAGE3 L antigen family, member 3 4.19555
LSR lipolysis stimulated lipoprotein receptor 4.16031
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) 4.10503
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 4.06964
EVL Enah/Vasp-like 4.02419
TERT telomerase reverse transcriptase 3.90461
MICALL1 MICAL-like 1 3.85969
HLA-DMA major histocompatibility complex, class II, DM alpha 3.78329
STX4 syntaxin 4 3.65684
RAB11FIP2 RAB11 family interacting protein 2 (class I) 3.62527
H2BC12 H2B clustered histone 12 3.62369
THOC6 THO complex 6 3.54484
CD72 CD72 molecule 3.49626
PIH1D1 PIH1 domain containing 1 3.29691
SCRN1 secernin 1 3.13238
GALT galactose-1-phosphate uridylyltransferase 3.05707
OXCT1 3-oxoacid CoA transferase 1 3.05632
CHMP6 charged multivesicular body protein 6 3.03153
BLMH bleomycin hydrolase 3.00665
TIMP2 TIMP metallopeptidase inhibitor 2 3.00047
NUBP2 nucleotide binding protein 2 2.98822
PFKL phosphofructokinase, liver 2.9781
RRAGA Ras-related GTP binding A 2.85991
ADO 2-aminoethanethiol (cysteamine) dioxygenase 2.81858
SQOR sulfide quinone oxidoreductase 2.77041
RB1 retinoblastoma 1 2.74969
PCDHB12 protocadherin beta 12 2.7195
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.68545
EDN1 endothelin 1 2.67496
KHDC1L KH homology domain containing 1-like 2.65897
SH3D19 SH3 domain containing 19 2.63408
PDE2A phosphodiesterase 2A, cGMP-stimulated 2.60849
PPP1R13B protein phosphatase 1, regulatory subunit 13B 2.59834
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 2.59242
TRAK2 trafficking protein, kinesin binding 2 2.58503
TENT4A terminal nucleotidyltransferase 4A 2.58497
MCM3 minichromosome maintenance complex component 3 2.55375
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) 2.53312
ANO1 anoctamin 1, calcium activated chloride channel 2.50831
KCNG2 potassium channel, voltage gated modifier subfamily G, member 2 2.49362
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 2.48032
IQSEC1 IQ motif and Sec7 domain 1 2.44424
BPHL biphenyl hydrolase-like (serine hydrolase) 2.42262
NUPR1 nuclear protein, transcriptional regulator, 1 2.39757
MAGEA6 melanoma antigen family A6 2.36808
STAP2 signal transducing adaptor family member 2 2.36738
DPF2 D4, zinc and double PHD fingers family 2 2.35416
NPTXR neuronal pentraxin receptor 2.34093
PEF1 penta-EF-hand domain containing 1 2.33761
ZNF232 zinc finger protein 232 2.32155
NIT1 nitrilase 1 2.31101
PRR15L proline rich 15-like 2.29775
IDH3G isocitrate dehydrogenase 3 (NAD+) gamma 2.29647
ECH1 enoyl CoA hydratase 1, peroxisomal 2.29566
SKI SKI proto-oncogene 2.28673
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) 2.28657
TRIM2 tripartite motif containing 2 2.28258
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) 2.27812
PTPRF protein tyrosine phosphatase, receptor type, F 2.26165
DDX41 DEAD (Asp-Glu-Ala-Asp) box polypeptide 41 2.25943
RENBP renin binding protein 2.25927
DNAJC17 DnaJ (Hsp40) homolog, subfamily C, member 17 2.25774
ALOX12B arachidonate 12-lipoxygenase, 12R type 2.25278
EIF2B1 eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa 2.24662
PCDH7 protocadherin 7 2.24494
EFNA4 ephrin-A4 2.23324
ZNF623 zinc finger protein 623 2.22474
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 2.2228
RAB4A RAB4A, member RAS oncogene family 2.22178
PICALM phosphatidylinositol binding clathrin assembly protein 2.20823
GATA2 GATA binding protein 2 2.20167
EFNA3 ephrin-A3 2.19361
MICB MHC class I polypeptide-related sequence B 2.16192
ZFPM1 zinc finger protein, FOG family member 1 2.15266
SMU1 smu-1 suppressor of mec-8 and unc-52 homolog (C. elegans) 2.1509
SEPHS2 selenophosphate synthetase 2 2.14082
MECR mitochondrial trans-2-enoyl-CoA reductase 2.13372
ITM2B integral membrane protein 2B 2.13341
NONO non-POU domain containing, octamer-binding 2.13314
PCDHB6 protocadherin beta 6 2.12962
ANKRD46 ankyrin repeat domain 46 2.11997
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.1196
ZNF318 zinc finger protein 318 2.11799
FOXD2 forkhead box D2 2.11294
CCDC69 coiled-coil domain containing 69 2.10404
DYNC1I1 dynein, cytoplasmic 1, intermediate chain 1 2.10347
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific 2.09892
MAP3K4 mitogen-activated protein kinase kinase kinase 4 2.09719
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 2.09571
HMHB1 histocompatibility (minor) HB-1 2.092
LY6H lymphocyte antigen 6 complex, locus H 2.09158
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 2.08436
CDK11A cyclin-dependent kinase 11A 2.08257
APOC3 apolipoprotein C-III 2.08181
MAGEA11 melanoma antigen family A11 2.0764
EIF3CL eukaryotic translation initiation factor 3, subunit C-like 2.07331
ERO1B endoplasmic reticulum oxidoreductase 1 beta 2.06656
COQ8A coenzyme Q8A 2.0662
KCNK13 potassium channel, two pore domain subfamily K, member 13 2.06363
TRIB2 tribbles pseudokinase 2 2.05131
KCNK12 potassium channel, two pore domain subfamily K, member 12 2.05113
TEDC2 tubulin epsilon and delta complex 2 2.0485
CBR3 carbonyl reductase 3 2.03299
LGALS8 lectin, galactoside-binding, soluble, 8 2.02843
DHX38 DEAH (Asp-Glu-Ala-His) box polypeptide 38 2.02737
FRMPD1 FERM and PDZ domain containing 1 2.02106
APOB apolipoprotein B 2.0143
PSORS1C2 psoriasis susceptibility 1 candidate 2 2.01423
NR1H2 nuclear receptor subfamily 1, group H, member 2 2.01353
TMEM132A transmembrane protein 132A 2.00464
HCK HCK proto-oncogene, Src family tyrosine kinase 2.00267
DNASE1L2 deoxyribonuclease I-like 2 2.00267
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone) 2.00155

decreased expression

Symbol Name Standardized Value
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -8.67583
CCNB2 cyclin B2 -8.31965
TLCD3A TLC domain containing 3A -7.82797
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -7.47107
PCNA proliferating cell nuclear antigen -5.64164
ARID5B AT rich interactive domain 5B (MRF1-like) -5.56447
TSEN2 TSEN2 tRNA splicing endonuclease subunit -5.4351
UBE3C ubiquitin protein ligase E3C -5.27176
HAT1 histone acetyltransferase 1 -5.19916
TUBB6 tubulin, beta 6 class V -5.13133
COG2 component of oligomeric golgi complex 2 -4.79198
FAIM Fas apoptotic inhibitory molecule -4.72066
PTPRK protein tyrosine phosphatase, receptor type, K -4.62382
FBXL12 F-box and leucine-rich repeat protein 12 -4.59399
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -4.49442
ISOC1 isochorismatase domain containing 1 -4.41721
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -4.39603
FASTKD5 FAST kinase domains 5 -4.28531
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -4.2596
ITFG1 integrin alpha FG-GAP repeat containing 1 -4.24178
PCCB propionyl CoA carboxylase, beta polypeptide -4.14869
PECR peroxisomal trans-2-enoyl-CoA reductase -4.08108
GTPBP8 GTP-binding protein 8 (putative) -4.07016
TM9SF3 transmembrane 9 superfamily member 3 -3.92789
DPH2 DPH2 homolog (S. cerevisiae) -3.90203
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae) -3.89086
CAB39 calcium binding protein 39 -3.71245
TARBP1 TAR (HIV-1) RNA binding protein 1 -3.70083
ANKRD10 ankyrin repeat domain 10 -3.66306
TCEAL4 transcription elongation factor A (SII)-like 4 -3.64783
NGRN neugrin, neurite outgrowth associated -3.62904
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -3.62303
ZNF586 zinc finger protein 586 -3.59845
SLC35A1 solute carrier family 35 (CMP-sialic acid transporter), member A1 -3.52982
SLC35F2 solute carrier family 35, member F2 -3.49567
NLRP2B NLR family pyrin domain containing 2B -3.41669
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 -3.35287
CCNB1 cyclin B1 -3.30922
ZW10 zw10 kinetochore protein -3.25824
RNASE7 ribonuclease, RNase A family, 7 -3.25226
NT5DC2 5'-nucleotidase domain containing 2 -3.22249
EPRS1 glutamyl-prolyl-tRNA synthetase 1 -3.20659
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 -3.17534
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -3.01709
WASHC4 WASH complex subunit 4 -2.94487
HSPB1 heat shock 27kDa protein 1 -2.92017
NRIP1 nuclear receptor interacting protein 1 -2.91936
CYB561D2 cytochrome b561 family, member D2 -2.90783
NUP62 nucleoporin 62kDa -2.85731
HEATR1 HEAT repeat containing 1 -2.82111
DIXDC1 DIX domain containing 1 -2.75111
SLC75A1 solute carrier family 75 member 1 -2.66445
CDC25B cell division cycle 25B -2.65273
NR2F6 nuclear receptor subfamily 2, group F, member 6 -2.65049
MRPL39 mitochondrial ribosomal protein L39 -2.64348
MTA1 metastasis associated 1 -2.61115
MYCBP MYC binding protein -2.60734
DHRS7 dehydrogenase/reductase (SDR family) member 7 -2.55871
SCCPDH saccharopine dehydrogenase (putative) -2.51589
NUP37 nucleoporin 37kDa -2.46533
TCTN1 tectonic family member 1 -2.44605
MRPS16 mitochondrial ribosomal protein S16 -2.42162
XPO7 exportin 7 -2.35672
GLOD4 glyoxalase domain containing 4 -2.32467
NAE1 NEDD8 activating enzyme E1 subunit 1 -2.30957
USP9X ubiquitin specific peptidase 9, X-linked -2.28538
OLA1 Obg-like ATPase 1 -2.24123
S100A13 S100 calcium binding protein A13 -2.23079
ZNF324 zinc finger protein 324 -2.21742
FRS2 fibroblast growth factor receptor substrate 2 -2.20929
TWF2 twinfilin actin binding protein 2 -2.18984
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -2.18781
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -2.17367
TLR4 toll-like receptor 4 -2.16455
HMG20B high mobility group 20B -2.16206
FASTKD1 FAST kinase domains 1 -2.15592
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10 -2.15109
FOS FBJ murine osteosarcoma viral oncogene homolog -2.13612
TENM4 teneurin transmembrane protein 4 -2.11442
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -2.101
AKAP8 A kinase (PRKA) anchor protein 8 -2.09806
DNAJC10 DnaJ (Hsp40) homolog, subfamily C, member 10 -2.091
TDRD7 tudor domain containing 7 -2.08911
PIK3R4 phosphoinositide-3-kinase, regulatory subunit 4 -2.08416
VDAC1 voltage-dependent anion channel 1 -2.08076
HTRA1 HtrA serine peptidase 1 -2.07545
PIGF phosphatidylinositol glycan anchor biosynthesis, class F -2.06545
TTC12 tetratricopeptide repeat domain 12 -2.06172
BAMBI BMP and activin membrane-bound inhibitor -2.04996
UFM1 ubiquitin-fold modifier 1 -2.01344
MISP mitotic spindle positioning -2.01117
SLC25A12 solute carrier family 25 (aspartate/glutamate carrier), member 12 -2.00922
ISOC2 isochorismatase domain containing 2 -2.00648
TAF5L TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa -2.00321
RSU1 Ras suppressor protein 1 -2.0007