CRCGN010_HEPG2_24H:J04 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2-methyl-2-[4-(1,2,3,4-tetrahydro-1-naphthalenyl)phenoxy]propanoic acid 2.66 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

47 genes differentially expressed following the CRCGN010_HEPG2_24H:J04 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CYCS cytochrome c, somatic 6.17217
CCNF cyclin F 5.61861
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 4.90607
UBQLN2 ubiquilin 2 4.72118
E2F2 E2F transcription factor 2 4.51454
LCN2 lipocalin 2 4.39236
SRC SRC proto-oncogene, non-receptor tyrosine kinase 3.66891
CCL2 chemokine (C-C motif) ligand 2 3.54667
SFTPB surfactant protein B 3.3996
EVL Enah/Vasp-like 3.37006
CHN1 chimerin 1 2.78077
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.76462
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 2.64265
SLC75A1 solute carrier family 75 member 1 2.58509
ZNF589 zinc finger protein 589 2.42508
TREM1 triggering receptor expressed on myeloid cells 1 2.3769
CHEK2 checkpoint kinase 2 2.34054
NMU neuromedin U 2.30294
LOC122526780 uncharacterized LOC122526780 2.08533
CXCL2 chemokine (C-X-C motif) ligand 2 2.08448
BLMH bleomycin hydrolase 2.06598
GPATCH8 G patch domain containing 8 2.06383
TPD52L2 tumor protein D52-like 2 2.05851
HSPA1A heat shock 70kDa protein 1A 2.04181
PHACTR4 phosphatase and actin regulator 4 2.03857

decreased expression

Symbol Name Standardized Value
NGRN neugrin, neurite outgrowth associated -5.65312
CCNB2 cyclin B2 -4.8576
KDM3A lysine (K)-specific demethylase 3A -4.63048
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.40928
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -4.29228
PCNA proliferating cell nuclear antigen -4.15194
ZNF586 zinc finger protein 586 -4.09657
ZW10 zw10 kinetochore protein -4.01939
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -3.80704
CAB39 calcium binding protein 39 -3.63432
PRPF4 pre-mRNA processing factor 4 -3.3942
TLR4 toll-like receptor 4 -3.28294
ADI1 acireductone dioxygenase 1 -3.24818
ISOC1 isochorismatase domain containing 1 -3.09605
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -2.96851
CPNE3 copine III -2.87552
GOLT1B golgi transport 1B -2.86465
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 -2.74387
PDHX pyruvate dehydrogenase complex, component X -2.65489
PCCB propionyl CoA carboxylase, beta polypeptide -2.58353
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) -2.43293
FASTKD5 FAST kinase domains 5 -2.01015