CRCGN010_HEPG2_24H:J05 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2-methyl-2-[4-(1,2,3,4-tetrahydro-1-naphthalenyl)phenoxy]propanoic acid 1.33 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

82 genes differentially expressed following the CRCGN010_HEPG2_24H:J05 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CIAO3 cytosolic iron-sulfur assembly component 3 7.85151
UBQLN2 ubiquilin 2 6.23922
CYCS cytochrome c, somatic 6.19406
MYLK myosin light chain kinase 4.2052
CCNF cyclin F 4.0704
SQOR sulfide quinone oxidoreductase 4.04191
ADRB2 adrenoceptor beta 2, surface 3.8596
PMM2 phosphomannomutase 2 3.70898
LYN LYN proto-oncogene, Src family tyrosine kinase 3.61606
RPP38 ribonuclease P/MRP 38kDa subunit 3.52322
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 3.05424
SFTPB surfactant protein B 3.03791
FZD7 frizzled class receptor 7 3.03101
ABHD6 abhydrolase domain containing 6 2.95203
MAP3K4 mitogen-activated protein kinase kinase kinase 4 2.92321
CYB561 cytochrome b561 2.9105
STIMATE STIM activating enhancer 2.87552
HLA-DRA major histocompatibility complex, class II, DR alpha 2.83516
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 2.54669
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 2.45176
CHN1 chimerin 1 2.39333
NR1H2 nuclear receptor subfamily 1, group H, member 2 2.30988
CXCL2 chemokine (C-X-C motif) ligand 2 2.15578
MAP7 microtubule-associated protein 7 2.12149
GATA2 GATA binding protein 2 2.06035
GARRE1 granule associated Rac and RHOG effector 1 2.05725
TEX10 testis expressed 10 2.04394
TCFL5 transcription factor-like 5 (basic helix-loop-helix) 2.04336

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -6.43109
ZNF586 zinc finger protein 586 -5.89833
MAPK13 mitogen-activated protein kinase 13 -4.52424
COG7 component of oligomeric golgi complex 7 -4.22366
GNAS GNAS complex locus -3.89574
CCNB2 cyclin B2 -3.72193
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.64773
NISCH nischarin -3.64512
OXA1L oxidase (cytochrome c) assembly 1-like -3.19508
CTSD cathepsin D -2.94878
USP36 ubiquitin specific peptidase 36 -2.65902
PEG10 paternally expressed 10 -2.65789
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 -2.57601
TRMT2B tRNA methyltransferase 2 homolog B (S. cerevisiae) -2.55318
HTN1 histatin 1 -2.48749
ABITRAM actin binding transcription modulator -2.42377
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -2.42208
HTN3 histatin 3 -2.4036
PCDHA2 protocadherin alpha 2 -2.38005
C15ORF38-AP3S2 C15orf38-AP3S2 readthrough -2.30899
VDAC1 voltage-dependent anion channel 1 -2.30438
RNF125 ring finger protein 125, E3 ubiquitin protein ligase -2.25852
FN3K fructosamine 3 kinase -2.25756
ADGRF1 adhesion G protein-coupled receptor F1 -2.25132
GRTP1 growth hormone regulated TBC protein 1 -2.23873
TMEM53 transmembrane protein 53 -2.23473
KCNJ14 potassium channel, inwardly rectifying subfamily J, member 14 -2.18877
MUC7 mucin 7, secreted -2.17111
CEMP1 cementum protein 1 -2.17004
ETV3 ets variant 3 -2.16009
CHRND cholinergic receptor, nicotinic, delta (muscle) -2.14887
TEP1 telomerase-associated protein 1 -2.14436
MPC2 mitochondrial pyruvate carrier 2 -2.13558
ANXA10 annexin A10 -2.12252
IFNA6 interferon, alpha 6 -2.11282
VPREB1 pre-B lymphocyte 1 -2.09956
PCDHGC3 protocadherin gamma subfamily C, 3 -2.0944
PPP4R3B protein phosphatase 4 regulatory subunit 3B -2.08796
SGCA sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein) -2.07529
KRT3 keratin 3, type II -2.0709
EIF5 eukaryotic translation initiation factor 5 -2.06751
TBKBP1 TBK1 binding protein 1 -2.0646
RNASE12 ribonuclease, RNase A family, 12 (non-active) -2.05965
ADAMTSL2 ADAMTS-like 2 -2.0547
PDE11A phosphodiesterase 11A -2.04772
MYF6 myogenic factor 6 (herculin) -2.04709
GPR37L1 G protein-coupled receptor 37 like 1 -2.04679
LSP1 lymphocyte-specific protein 1 -2.04405
NAA16 N(alpha)-acetyltransferase 16, NatA auxiliary subunit -2.04232
CDKL3 cyclin-dependent kinase-like 3 -2.03601
PDHX pyruvate dehydrogenase complex, component X -2.0296
OR2H2 olfactory receptor, family 2, subfamily H, member 2 -2.01701
ZNF667 zinc finger protein 667 -2.01694
RBM34 RNA binding motif protein 34 -2.00101