| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | 2-methyl-2-[4-(1,2,3,4-tetrahydro-1-naphthalenyl)phenoxy]propanoic acid 0.66 um perturbation at 24 h in HEPG2 (Carcinogenome) |
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60 genes differentially expressed following the CRCGN010_HEPG2_24H:J06 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NMU | neuromedin U | 6.42128 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 5.17889 |
| LCN2 | lipocalin 2 | 4.81722 |
| HERC6 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 | 4.48522 |
| CHN1 | chimerin 1 | 4.37596 |
| GSTZ1 | glutathione S-transferase zeta 1 | 3.66763 |
| MCOLN1 | mucolipin 1 | 3.65462 |
| MLLT11 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 | 3.51885 |
| BAX | BCL2-associated X protein | 3.46974 |
| NOSIP | nitric oxide synthase interacting protein | 3.30128 |
| CCL2 | chemokine (C-C motif) ligand 2 | 3.23587 |
| EVL | Enah/Vasp-like | 3.22674 |
| EPN2 | epsin 2 | 3.2199 |
| CEBPZ | CCAAT/enhancer binding protein (C/EBP), zeta | 3.00628 |
| MICALL1 | MICAL-like 1 | 2.86507 |
| CCNA1 | cyclin A1 | 2.82531 |
| LOC122526780 | uncharacterized LOC122526780 | 2.54408 |
| AAMP | angio-associated, migratory cell protein | 2.53453 |
| DIPK1A | divergent protein kinase domain 1A | 2.33361 |
| PFKL | phosphofructokinase, liver | 2.25574 |
| MAST2 | microtubule associated serine/threonine kinase 2 | 2.24924 |
| CCNF | cyclin F | 2.2379 |
| FAM131A | family with sequence similarity 131, member A | 2.22027 |
| GPER1 | G protein-coupled estrogen receptor 1 | 2.169 |
| CRTAP | cartilage associated protein | 2.16504 |
| VGLL4 | vestigial-like family member 4 | 2.1446 |
| EZH2 | enhancer of zeste 2 polycomb repressive complex 2 subunit | 2.05876 |
| CD40 | CD40 molecule, TNF receptor superfamily member 5 | 2.058 |
| ATP6V1E1 | ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1 | 2.00621 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ST6GALNAC2 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 | -8.68338 |
| ZNF586 | zinc finger protein 586 | -7.04798 |
| BLCAP | bladder cancer associated protein | -5.30012 |
| HSD17B11 | hydroxysteroid (17-beta) dehydrogenase 11 | -5.14578 |
| IARS2 | isoleucyl-tRNA synthetase 2, mitochondrial | -4.61104 |
| TLCD3A | TLC domain containing 3A | -4.47228 |
| CD320 | CD320 molecule | -4.41141 |
| PCNA | proliferating cell nuclear antigen | -3.99776 |
| OXA1L | oxidase (cytochrome c) assembly 1-like | -3.89559 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | -3.66419 |
| TLR4 | toll-like receptor 4 | -3.58217 |
| XPO7 | exportin 7 | -3.38442 |
| PCCB | propionyl CoA carboxylase, beta polypeptide | -3.23371 |
| GTPBP8 | GTP-binding protein 8 (putative) | -3.0541 |
| EIF5 | eukaryotic translation initiation factor 5 | -2.77871 |
| SNX11 | sorting nexin 11 | -2.64951 |
| DDX3Y | DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked | -2.60408 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | -2.5499 |
| WASHC4 | WASH complex subunit 4 | -2.47838 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -2.37344 |
| FGFR4 | fibroblast growth factor receptor 4 | -2.31621 |
| LSM1 | LSM1, U6 small nuclear RNA associated | -2.20212 |
| SCGB1D2 | secretoglobin, family 1D, member 2 | -2.16539 |
| TNF | tumor necrosis factor | -2.12365 |
| ASB9 | ankyrin repeat and SOCS box containing 9 | -2.1006 |
| RASL11B | RAS-like, family 11, member B | -2.08257 |
| LOC107985101 | uncharacterized LOC107985101 | -2.0768 |
| PCF11 | PCF11 cleavage and polyadenylation factor subunit | -2.06292 |
| MRPL48 | mitochondrial ribosomal protein L48 | -2.058 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -2.03492 |
| DBF4B | DBF4 zinc finger B | -2.01005 |
