| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | 4-(1-methyl-2-oxohydrazino)-1-(3-pyridinyl)-1-butanone 20.11 um perturbation at 24 h in HEPG2 (Carcinogenome) |
| Similar Terms | |
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72 genes differentially expressed following the CRCGN010_HEPG2_24H:J07 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GPER1 | G protein-coupled estrogen receptor 1 | 5.54878 |
| CSK | c-src tyrosine kinase | 5.34789 |
| ATP11B | ATPase, class VI, type 11B | 5.05618 |
| NUDT9 | nudix (nucleoside diphosphate linked moiety X)-type motif 9 | 5.05038 |
| MSRA | methionine sulfoxide reductase A | 4.89322 |
| HERC6 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 | 4.50045 |
| CHMP6 | charged multivesicular body protein 6 | 4.1932 |
| TATDN2 | TatD DNase domain containing 2 | 4.15741 |
| GARRE1 | granule associated Rac and RHOG effector 1 | 4.04918 |
| P4HTM | prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) | 3.98083 |
| MAP7 | microtubule-associated protein 7 | 3.53997 |
| HLA-DMA | major histocompatibility complex, class II, DM alpha | 3.27041 |
| EPN2 | epsin 2 | 3.11482 |
| MAPKAPK5 | mitogen-activated protein kinase-activated protein kinase 5 | 3.07036 |
| TIAM1 | T-cell lymphoma invasion and metastasis 1 | 3.00232 |
| H2BC21 | H2B clustered histone 21 | 2.94903 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 2.83232 |
| DIPK1A | divergent protein kinase domain 1A | 2.79351 |
| PLSCR3 | phospholipid scramblase 3 | 2.78812 |
| VGLL4 | vestigial-like family member 4 | 2.77717 |
| CRBN | cereblon | 2.61571 |
| JADE2 | jade family PHD finger 2 | 2.56527 |
| STIMATE | STIM activating enhancer | 2.5218 |
| EDN1 | endothelin 1 | 2.47749 |
| PHKA1 | phosphorylase kinase, alpha 1 (muscle) | 2.43459 |
| SSBP2 | single-stranded DNA binding protein 2 | 2.42702 |
| LY6E | lymphocyte antigen 6 complex, locus E | 2.3991 |
| CHN1 | chimerin 1 | 2.37247 |
| COPS7A | COP9 signalosome subunit 7A | 2.35853 |
| GPATCH8 | G patch domain containing 8 | 2.34514 |
| CNPY3 | canopy FGF signaling regulator 3 | 2.33764 |
| PLA2G4A | phospholipase A2, group IVA (cytosolic, calcium-dependent) | 2.30113 |
| IKZF1 | IKAROS family zinc finger 1 (Ikaros) | 2.29731 |
| NR1H2 | nuclear receptor subfamily 1, group H, member 2 | 2.22461 |
| TGFBR2 | transforming growth factor, beta receptor II (70/80kDa) | 2.14783 |
| SAMHD1 | SAM domain and HD domain 1 | 2.04784 |
| RRS1 | RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) | 2.0285 |
| B3GALT2 | UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2 | 2.02467 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CCDC86 | coiled-coil domain containing 86 | -9.40701 |
| TLE1 | transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) | -5.99233 |
| CDKN1B | cyclin-dependent kinase inhibitor 1B (p27, Kip1) | -5.17496 |
| CASP7 | caspase 7, apoptosis-related cysteine peptidase | -5.16374 |
| ENOPH1 | enolase-phosphatase 1 | -4.82726 |
| OXA1L | oxidase (cytochrome c) assembly 1-like | -4.59301 |
| DSG2 | desmoglein 2 | -4.45658 |
| ZDHHC6 | zinc finger, DHHC-type containing 6 | -4.3278 |
| PLEKHJ1 | pleckstrin homology domain containing, family J member 1 | -4.13137 |
| NT5DC2 | 5'-nucleotidase domain containing 2 | -4.12947 |
| TLCD3A | TLC domain containing 3A | -3.79997 |
| CCNB2 | cyclin B2 | -3.49599 |
| FGFR4 | fibroblast growth factor receptor 4 | -3.21533 |
| SLC35F2 | solute carrier family 35, member F2 | -3.12936 |
| PKIG | protein kinase (cAMP-dependent, catalytic) inhibitor gamma | -3.08286 |
| TM9SF3 | transmembrane 9 superfamily member 3 | -3.03173 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | -2.97625 |
| ZNF586 | zinc finger protein 586 | -2.90844 |
| DDIT4 | DNA-damage-inducible transcript 4 | -2.52531 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | -2.405 |
| PRPF4 | pre-mRNA processing factor 4 | -2.29509 |
| DDB1 | damage-specific DNA binding protein 1, 127kDa | -2.28172 |
| YTHDF1 | YTH N(6)-methyladenosine RNA binding protein 1 | -2.24993 |
| RBM15 | RNA binding motif protein 15 | -2.22762 |
| PECR | peroxisomal trans-2-enoyl-CoA reductase | -2.21309 |
| STX3 | syntaxin 3 | -2.15981 |
| ANAPC15 | anaphase promoting complex subunit 15 | -2.15128 |
| UPF1 | UPF1 regulator of nonsense transcripts homolog (yeast) | -2.14532 |
| CD58 | CD58 molecule | -2.09663 |
| OSBP | oxysterol binding protein | -2.06067 |
| SLC7A5 | solute carrier family 7 (amino acid transporter light chain, L system), member 5 | -2.05889 |
| UROS | uroporphyrinogen III synthase | -2.04999 |
| LSM5 | LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) | -2.04799 |
| FHL2 | four and a half LIM domains 2 | -2.00728 |
