CRCGN010_HEPG2_24H:J08 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 4-(1-methyl-2-oxohydrazino)-1-(3-pyridinyl)-1-butanone 10.05 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

96 genes differentially expressed following the CRCGN010_HEPG2_24H:J08 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 6.46092
MAP7 microtubule-associated protein 7 6.06085
STIMATE STIM activating enhancer 5.68672
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 5.22531
CYCS cytochrome c, somatic 4.8228
E2F2 E2F transcription factor 2 4.73918
SQOR sulfide quinone oxidoreductase 4.64735
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 4.63855
CIAO3 cytosolic iron-sulfur assembly component 3 4.60709
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 4.56301
EAPP E2F-associated phosphoprotein 4.54183
NOTCH1 notch 1 4.46509
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 4.37879
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 4.29966
RPL39L ribosomal protein L39-like 4.28672
HOXA10 homeobox A10 4.22931
HDGFL3 HDGF like 3 4.22371
EPHB2 EPH receptor B2 3.82325
GFOD1 glucose-fructose oxidoreductase domain containing 1 3.77726
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 3.67697
CHMP6 charged multivesicular body protein 6 3.66621
NOSIP nitric oxide synthase interacting protein 3.31972
PRR15L proline rich 15-like 3.22544
GSTZ1 glutathione S-transferase zeta 1 3.14064
EPN2 epsin 2 3.09404
BAMBI BMP and activin membrane-bound inhibitor 3.07375
RAB21 RAB21, member RAS oncogene family 3.04199
PRKCH protein kinase C, eta 3.04097
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 2.99758
CEP57 centrosomal protein 57kDa 2.97643
GATA3 GATA binding protein 3 2.9044
ZFP36 ZFP36 ring finger protein 2.82579
UBQLN2 ubiquilin 2 2.77732
BPHL biphenyl hydrolase-like (serine hydrolase) 2.69911
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta 2.69521
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein 2.68071
RRAGA Ras-related GTP binding A 2.64063
GPATCH8 G patch domain containing 8 2.56945
GPER1 G protein-coupled estrogen receptor 1 2.53996
LOC122526780 uncharacterized LOC122526780 2.50583
ZNF589 zinc finger protein 589 2.49854
HDAC4 histone deacetylase 4 2.36137
PCDHB11 protocadherin beta 11 2.31835
JADE2 jade family PHD finger 2 2.31554
HLA-DMA major histocompatibility complex, class II, DM alpha 2.25878
ACVRL1 activin A receptor type II-like 1 2.15934
CNTFR ciliary neurotrophic factor receptor 2.15838
TPSG1 tryptase gamma 1 2.14846
ZNF248 zinc finger protein 248 2.13532
LUC7L LUC7-like (S. cerevisiae) 2.12933
CHN1 chimerin 1 2.11221
ZNF143 zinc finger protein 143 2.06875
PRMT1 protein arginine methyltransferase 1 2.06584
THBS3 thrombospondin 3 2.05835
GCGR glucagon receptor 2.05827
REM1 RAS (RAD and GEM)-like GTP-binding 1 2.04032
NRBP1 nuclear receptor binding protein 1 2.02342
ZSCAN16 zinc finger and SCAN domain containing 16 2.01609
CCL21 chemokine (C-C motif) ligand 21 2.01105
NSD1 nuclear receptor binding SET domain protein 1 2.01054
WFS1 Wolfram syndrome 1 (wolframin) 2.00163

decreased expression

Symbol Name Standardized Value
PCNA proliferating cell nuclear antigen -8.251
KDM3A lysine (K)-specific demethylase 3A -6.2683
ADI1 acireductone dioxygenase 1 -5.52903
DSG2 desmoglein 2 -5.11713
CDC25B cell division cycle 25B -4.53407
PCCB propionyl CoA carboxylase, beta polypeptide -4.51614
MRPS2 mitochondrial ribosomal protein S2 -4.44398
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -4.31023
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -4.06
ITFG1 integrin alpha FG-GAP repeat containing 1 -4.01049
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -3.97811
OXA1L oxidase (cytochrome c) assembly 1-like -3.79272
LYPLA1 lysophospholipase I -3.77366
COG2 component of oligomeric golgi complex 2 -3.73217
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -3.63819
VAT1 vesicle amine transport 1 -3.61514
TLCD3A TLC domain containing 3A -3.53357
TM9SF3 transmembrane 9 superfamily member 3 -3.30625
PDZD2 PDZ domain containing 2 -3.25671
VDAC1 voltage-dependent anion channel 1 -3.02939
PPOX protoporphyrinogen oxidase -2.88243
NGRN neugrin, neurite outgrowth associated -2.8789
SLC35F2 solute carrier family 35, member F2 -2.74365
PRPF4 pre-mRNA processing factor 4 -2.72293
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -2.60701
C2CD5 C2 calcium-dependent domain containing 5 -2.58125
SCAND1 SCAN domain containing 1 -2.4107
CD58 CD58 molecule -2.40691
ITGB1BP1 integrin beta 1 binding protein 1 -2.33539
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -2.25922
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family) -2.19306
CP ceruloplasmin (ferroxidase) -2.18856
NOP56 NOP56 ribonucleoprotein -2.08407
RAP2A RAP2A, member of RAS oncogene family -2.07428
CDK5RAP1 CDK5 regulatory subunit associated protein 1 -2.01613