| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | 4-(1-methyl-2-oxohydrazino)-1-(3-pyridinyl)-1-butanone 5.03 um perturbation at 24 h in HEPG2 (Carcinogenome) |
| Similar Terms | |
| Downloads & Tools |
66 genes differentially expressed following the CRCGN010_HEPG2_24H:J09 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ABCC5 | ATP-binding cassette, sub-family C (CFTR/MRP), member 5 | 5.35558 |
| GPER1 | G protein-coupled estrogen receptor 1 | 5.08427 |
| CHMP6 | charged multivesicular body protein 6 | 4.56314 |
| CYCS | cytochrome c, somatic | 4.44438 |
| DYRK3 | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 | 4.22071 |
| MAMLD1 | mastermind-like domain containing 1 | 4.10342 |
| TEX10 | testis expressed 10 | 3.80965 |
| HLA-DRA | major histocompatibility complex, class II, DR alpha | 3.58632 |
| AGL | amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase | 3.54865 |
| ZNF589 | zinc finger protein 589 | 3.19469 |
| DYNLT3 | dynein, light chain, Tctex-type 3 | 3.12698 |
| ABHD6 | abhydrolase domain containing 6 | 3.07047 |
| EVL | Enah/Vasp-like | 3.06555 |
| PRR15L | proline rich 15-like | 2.87235 |
| MCUR1 | mitochondrial calcium uniporter regulator 1 | 2.83582 |
| TREM1 | triggering receptor expressed on myeloid cells 1 | 2.79526 |
| DNAJC15 | DnaJ (Hsp40) homolog, subfamily C, member 15 | 2.72968 |
| DHDDS | dehydrodolichyl diphosphate synthase | 2.66526 |
| FZD7 | frizzled class receptor 7 | 2.47546 |
| SCD5 | stearoyl-CoA desaturase 5 | 2.39026 |
| TSPAN6 | tetraspanin 6 | 2.37133 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 2.33832 |
| NUDT9 | nudix (nucleoside diphosphate linked moiety X)-type motif 9 | 2.27039 |
| BIRC2 | baculoviral IAP repeat containing 2 | 2.17268 |
| ENPP4 | ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative) | 2.1607 |
| CCL4 | chemokine (C-C motif) ligand 4 | 2.1508 |
| EDN1 | endothelin 1 | 2.13778 |
| MEGF8 | multiple EGF-like-domains 8 | 2.10745 |
| RPA3 | replication protein A3, 14kDa | 2.10619 |
| SEMA6D | sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D | 2.05588 |
| DGKI | diacylglycerol kinase, iota | 2.0318 |
| TMEM120B | transmembrane protein 120B | 2.00888 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ZDHHC6 | zinc finger, DHHC-type containing 6 | -9.18966 |
| OXA1L | oxidase (cytochrome c) assembly 1-like | -6.48869 |
| VAT1 | vesicle amine transport 1 | -5.99892 |
| SLC35F2 | solute carrier family 35, member F2 | -5.922 |
| CASP7 | caspase 7, apoptosis-related cysteine peptidase | -5.65276 |
| ST6GALNAC2 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 | -4.85523 |
| IARS2 | isoleucyl-tRNA synthetase 2, mitochondrial | -4.71845 |
| DNM1L | dynamin 1-like | -4.64602 |
| TUBB6 | tubulin, beta 6 class V | -4.56543 |
| CCDC86 | coiled-coil domain containing 86 | -4.38331 |
| CCNB2 | cyclin B2 | -4.26819 |
| MRPS2 | mitochondrial ribosomal protein S2 | -4.25428 |
| GOLT1B | golgi transport 1B | -3.45722 |
| DNAJA3 | DnaJ (Hsp40) homolog, subfamily A, member 3 | -3.39847 |
| RRP12 | ribosomal RNA processing 12 homolog (S. cerevisiae) | -3.28217 |
| FBXL12 | F-box and leucine-rich repeat protein 12 | -3.27935 |
| YME1L1 | YME1-like 1 ATPase | -3.10159 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -3.08132 |
| IDH1 | isocitrate dehydrogenase 1 (NADP+), soluble | -3.02307 |
| RFC2 | replication factor C (activator 1) 2, 40kDa | -2.92051 |
| MYL9 | myosin, light chain 9, regulatory | -2.68791 |
| EIF5 | eukaryotic translation initiation factor 5 | -2.62144 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | -2.48832 |
| ABRAXAS2 | abraxas 2, BRISC complex subunit | -2.31392 |
| ALKBH1 | alkB, alkylation repair homolog 1 (E. coli) | -2.2651 |
| NDC1 | NDC1 transmembrane nucleoporin | -2.12618 |
| NR2F6 | nuclear receptor subfamily 2, group F, member 6 | -2.12608 |
| TLE1 | transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) | -2.12579 |
| KCNN2 | potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2 | -2.08398 |
| NUP62CL | nucleoporin 62kDa C-terminal like | -2.08035 |
| RNF167 | ring finger protein 167 | -2.05755 |
| NUP133 | nucleoporin 133kDa | -2.04868 |
| PPP2R2D | protein phosphatase 2, regulatory subunit B, delta | -2.03008 |
| HSD3B2 | hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 | -2.01253 |
