CRCGN010_HEPG2_24H:J10 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 4-(1-methyl-2-oxohydrazino)-1-(3-pyridinyl)-1-butanone 2.51 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

118 genes differentially expressed following the CRCGN010_HEPG2_24H:J10 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PPARG peroxisome proliferator-activated receptor gamma 8.81808
MAP7 microtubule-associated protein 7 7.93958
TIAM1 T-cell lymphoma invasion and metastasis 1 6.25273
PPP1R13B protein phosphatase 1, regulatory subunit 13B 5.16658
CSK c-src tyrosine kinase 5.16133
MAMLD1 mastermind-like domain containing 1 4.81266
JADE2 jade family PHD finger 2 4.55561
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 4.48772
CXCL2 chemokine (C-X-C motif) ligand 2 4.40871
MOK MOK protein kinase 4.00297
DENND2D DENN/MADD domain containing 2D 3.966
ATP11B ATPase, class VI, type 11B 3.89635
PRR15L proline rich 15-like 3.72833
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 3.68864
IDE insulin-degrading enzyme 3.59061
NOTCH1 notch 1 3.58297
BZW2 basic leucine zipper and W2 domains 2 3.56651
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 3.52756
CASP2 caspase 2, apoptosis-related cysteine peptidase 3.47629
KCNK5 potassium channel, two pore domain subfamily K, member 5 2.6259
NUCB2 nucleobindin 2 2.60438
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.52757
SH3D19 SH3 domain containing 19 2.52497
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 2.48273
EVL Enah/Vasp-like 2.45619
RMND1 required for meiotic nuclear division 1 homolog (S. cerevisiae) 2.4373
NUP133 nucleoporin 133kDa 2.43001
BTK Bruton agammaglobulinemia tyrosine kinase 2.41229
ADAM10 ADAM metallopeptidase domain 10 2.40443
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha 2.35848
HAT1 histone acetyltransferase 1 2.30351
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2 2.2063
PLSCR3 phospholipid scramblase 3 2.16979
USH1C Usher syndrome 1C (autosomal recessive, severe) 2.15559
PEX26 peroxisomal biogenesis factor 26 2.12885
PMF1-BGLAP PMF1-BGLAP readthrough 2.06679
LASP1 LIM and SH3 protein 1 2.05068
FST follistatin 2.04454
POP5 processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae) 2.04444
RBBP5 retinoblastoma binding protein 5 2.04087

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -9.06185
TLR4 toll-like receptor 4 -7.74037
GNAS GNAS complex locus -6.12612
VAT1 vesicle amine transport 1 -5.14654
CDC25B cell division cycle 25B -5.13489
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -4.86461
DERA deoxyribose-phosphate aldolase (putative) -4.54421
THAP11 THAP domain containing 11 -4.27223
CCNB2 cyclin B2 -4.23718
GOLT1B golgi transport 1B -4.22985
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.00366
RNF167 ring finger protein 167 -3.76755
DCK deoxycytidine kinase -3.73815
DSG2 desmoglein 2 -3.6135
BLCAP bladder cancer associated protein -3.49875
CASP7 caspase 7, apoptosis-related cysteine peptidase -3.3177
CAB39 calcium binding protein 39 -3.11829
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -2.91778
CCNB1 cyclin B1 -2.67363
AAMP angio-associated, migratory cell protein -2.62939
HYOU1 hypoxia up-regulated 1 -2.61049
PPFIA2 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2 -2.5896
SESN1 sestrin 1 -2.5794
CALM3 calmodulin 3 (phosphorylase kinase, delta) -2.51516
FOXI1 forkhead box I1 -2.51228
FAM3C family with sequence similarity 3, member C -2.50658
NVL nuclear VCP-like -2.38699
GREM1 gremlin 1, DAN family BMP antagonist -2.36961
HRH2 histamine receptor H2 -2.33044
RLBP1 retinaldehyde binding protein 1 -2.32428
ADIPOR2 adiponectin receptor 2 -2.31917
NEUROD4 neuronal differentiation 4 -2.31505
CCT8L2 chaperonin containing TCP1, subunit 8 (theta)-like 2 -2.28556
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class) -2.28419
SPANXA1 sperm protein associated with the nucleus, X-linked, family member A1 -2.28253
RNF40 ring finger protein 40, E3 ubiquitin protein ligase -2.28222
PRRX1 paired related homeobox 1 -2.27622
E2F4 E2F transcription factor 4, p107/p130-binding -2.26837
TSPAN7 tetraspanin 7 -2.24198
ZNF557 zinc finger protein 557 -2.22517
INKA2 inka box actin regulator 2 -2.20936
PPM1G protein phosphatase, Mg2+/Mn2+ dependent, 1G -2.20618
GPR137 G protein-coupled receptor 137 -2.20388
KERA keratocan -2.20196
FUZ fuzzy planar cell polarity protein -2.19796
SLIT2 slit homolog 2 (Drosophila) -2.18152
RBM15B RNA binding motif protein 15B -2.18041
ADRA2B adrenoceptor alpha 2B -2.17896
MOXD1 monooxygenase, DBH-like 1 -2.1689
MLF2 myeloid leukemia factor 2 -2.14821
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D -2.14411
ELAVL4 ELAV like neuron-specific RNA binding protein 4 -2.14105
CCDC169-SOHLH2 CCDC169-SOHLH2 readthrough -2.13436
ACKR5 atypical chemokine receptor 5 -2.13233
NEUROD6 neuronal differentiation 6 -2.11557
CYP11B1 cytochrome P450, family 11, subfamily B, polypeptide 1 -2.10742
PRKG1 protein kinase, cGMP-dependent, type I -2.10588
PCDHGA9 protocadherin gamma subfamily A, 9 -2.10456
CAPN10 calpain 10 -2.09558
HCN4 hyperpolarization activated cyclic nucleotide gated potassium channel 4 -2.09414
GPR50 G protein-coupled receptor 50 -2.09081
E2F1 E2F transcription factor 1 -2.0906
SEMA3D sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D -2.07571
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -2.07481
GLI3 GLI family zinc finger 3 -2.05627
HTR2B 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled -2.03833
LINC02854 long intergenic non-protein coding RNA 2854 -2.03541
YBX2 Y box binding protein 2 -2.03315
MAGEA4 melanoma antigen family A4 -2.02844
TP53I11 tumor protein p53 inducible protein 11 -2.02735
CHRNA6 cholinergic receptor, nicotinic, alpha 6 (neuronal) -2.02259
GABARAP GABA(A) receptor-associated protein -2.01959
RIC3 RIC3 acetylcholine receptor chaperone -2.01747
ADAM2 ADAM metallopeptidase domain 2 -2.01481
PLD2 phospholipase D2 -2.01445
NDST4 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4 -2.01357
SPANXB1 SPANX family, member B1 -2.01276
ISL1 ISL LIM homeobox 1 -2.00349