CRCGN010_HEPG2_24H:J11 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 4-(1-methyl-2-oxohydrazino)-1-(3-pyridinyl)-1-butanone 1.26 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

87 genes differentially expressed following the CRCGN010_HEPG2_24H:J11 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PPARG peroxisome proliferator-activated receptor gamma 9.04645
CARMIL1 capping protein regulator and myosin 1 linker 1 8.86663
UBQLN2 ubiquilin 2 5.76676
KLHL21 kelch-like family member 21 4.82796
LCN2 lipocalin 2 4.77995
BACE2 beta-site APP-cleaving enzyme 2 4.54541
GSTZ1 glutathione S-transferase zeta 1 4.48033
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.37242
CHMP6 charged multivesicular body protein 6 4.32277
STIMATE STIM activating enhancer 4.28641
IKZF1 IKAROS family zinc finger 1 (Ikaros) 4.13306
HOXA10 homeobox A10 4.12848
EPHB2 EPH receptor B2 4.00802
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 3.84724
KDM5A lysine (K)-specific demethylase 5A 3.82176
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 3.76656
TIAM1 T-cell lymphoma invasion and metastasis 1 3.69951
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 3.67113
RRAGA Ras-related GTP binding A 3.61992
GATA3 GATA binding protein 3 3.50828
NMU neuromedin U 3.1966
GATA2 GATA binding protein 2 2.9968
CHN1 chimerin 1 2.96191
TBP TATA box binding protein 2.79068
VGLL4 vestigial-like family member 4 2.75474
GPATCH8 G patch domain containing 8 2.73534
SSBP2 single-stranded DNA binding protein 2 2.64704
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1 2.6282
BCL9 B-cell CLL/lymphoma 9 2.55302
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.5492
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.35258
AQP2 aquaporin 2 (collecting duct) 2.33954
SPTAN1 spectrin, alpha, non-erythrocytic 1 2.32321
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.28279
HBA1 hemoglobin, alpha 1 2.26043
DYNLT3 dynein, light chain, Tctex-type 3 2.25996
PCDHB11 protocadherin beta 11 2.24847
FANCF Fanconi anemia, complementation group F 2.22393
TREM1 triggering receptor expressed on myeloid cells 1 2.20783
CD3E CD3e molecule, epsilon (CD3-TCR complex) 2.2065
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 2.20625
APIP APAF1 interacting protein 2.13946
CLDN11 claudin 11 2.1361
FRYL FRY-like 2.11114
RTL8C retrotransposon Gag like 8C 2.08576
SFXN1 sideroflexin 1 2.0736
F13A1 coagulation factor XIII, A1 polypeptide 2.03991
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 2.0389
VAMP7 vesicle-associated membrane protein 7 2.03548
MEOX2 mesenchyme homeobox 2 2.02539
ACTR8 ARP8 actin-related protein 8 homolog (yeast) 2.01457
HEBP1 heme binding protein 1 2.00029

decreased expression

Symbol Name Standardized Value
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -8.69059
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -6.60394
CCDC86 coiled-coil domain containing 86 -4.92494
KDM3A lysine (K)-specific demethylase 3A -4.79561
CTSD cathepsin D -4.7687
TSPAN4 tetraspanin 4 -4.73362
C2CD5 C2 calcium-dependent domain containing 5 -4.69443
HAT1 histone acetyltransferase 1 -4.67492
TARBP1 TAR (HIV-1) RNA binding protein 1 -4.10948
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -4.06062
CHMP4B charged multivesicular body protein 4B -3.7724
NGRN neugrin, neurite outgrowth associated -3.50691
TLCD3A TLC domain containing 3A -3.49517
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2 -3.42717
CD58 CD58 molecule -3.28713
FGFR4 fibroblast growth factor receptor 4 -3.15369
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D -2.95689
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -2.86638
YME1L1 YME1-like 1 ATPase -2.78935
JMJD1C jumonji domain containing 1C -2.61592
CTNND1 catenin (cadherin-associated protein), delta 1 -2.44517
CPNE3 copine III -2.34961
FHOD1 formin homology 2 domain containing 1 -2.23382
VSIG10 V-set and immunoglobulin domain containing 10 -2.19823
IRX4 iroquois homeobox 4 -2.196
NECTIN3 nectin cell adhesion molecule 3 -2.17666
REEP5 receptor accessory protein 5 -2.17579
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) -2.14311
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -2.11743
MZT2A mitotic spindle organizing protein 2A -2.11682
RRAS2 related RAS viral (r-ras) oncogene homolog 2 -2.11661
NUP85 nucleoporin 85kDa -2.06738
SNRPD3 small nuclear ribonucleoprotein D3 polypeptide 18kDa -2.05198
GRHL2 grainyhead-like 2 (Drosophila) -2.05123
SRPK3 SRSF protein kinase 3 -2.0116