CRCGN010_HEPG2_24H:J13 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description DMSO perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

42 genes differentially expressed following the CRCGN010_HEPG2_24H:J13 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 6.20895
PRR15L proline rich 15-like 4.49821
STIMATE STIM activating enhancer 4.13406
DIPK1A divergent protein kinase domain 1A 3.88904
HLA-DMA major histocompatibility complex, class II, DM alpha 3.62822
E2F2 E2F transcription factor 2 3.60163
SFTPB surfactant protein B 3.29989
EPHB2 EPH receptor B2 3.15686
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble 3.10262
TIAM1 T-cell lymphoma invasion and metastasis 1 2.8785
NOTCH1 notch 1 2.72806
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 2.49042
UFM1 ubiquitin-fold modifier 1 2.46368
TREM1 triggering receptor expressed on myeloid cells 1 2.4635
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.42289
NMU neuromedin U 2.39531
C2CD2 C2 calcium-dependent domain containing 2 2.36467
PLSCR1 phospholipid scramblase 1 2.27789
GATA2 GATA binding protein 2 2.25689
NOSIP nitric oxide synthase interacting protein 2.17207
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha) 2.14314
CCL13 chemokine (C-C motif) ligand 13 2.06816
KLHL9 kelch-like family member 9 2.02804
TRIM6-TRIM34 TRIM6-TRIM34 readthrough 2.02401

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -6.99421
GTPBP8 GTP-binding protein 8 (putative) -5.95248
CASP7 caspase 7, apoptosis-related cysteine peptidase -5.64411
CDC20 cell division cycle 20 -3.95
PCNA proliferating cell nuclear antigen -3.74268
MRPS2 mitochondrial ribosomal protein S2 -3.49405
SLC35F2 solute carrier family 35, member F2 -2.97205
ZDHHC6 zinc finger, DHHC-type containing 6 -2.79691
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -2.71715
FGFR4 fibroblast growth factor receptor 4 -2.59656
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -2.52888
CRK v-crk avian sarcoma virus CT10 oncogene homolog -2.39922
CCNB2 cyclin B2 -2.34523
NRIP1 nuclear receptor interacting protein 1 -2.22928
CCDC25 coiled-coil domain containing 25 -2.16193
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked -2.14552
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -2.11106
ABHD10 abhydrolase domain containing 10 -2.0134