CRCGN010_HEPG2_24H:J16 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description DMSO perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

79 genes differentially expressed following the CRCGN010_HEPG2_24H:J16 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
E2F2 E2F transcription factor 2 6.33052
IDE insulin-degrading enzyme 4.85179
PNKP polynucleotide kinase 3'-phosphatase 4.43076
AMDHD2 amidohydrolase domain containing 2 4.22077
DYNLT3 dynein, light chain, Tctex-type 3 3.97886
GPER1 G protein-coupled estrogen receptor 1 3.61873
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 3.61725
C2CD2 C2 calcium-dependent domain containing 2 3.54082
CHMP6 charged multivesicular body protein 6 3.53737
ADGRE5 adhesion G protein-coupled receptor E5 3.53714
CSK c-src tyrosine kinase 3.5327
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 3.29394
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 3.27374
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 3.26565
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 3.23021
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 3.21206
EVL Enah/Vasp-like 3.20364
LCN2 lipocalin 2 3.17077
UBE2A ubiquitin-conjugating enzyme E2A 2.93248
UBQLN2 ubiquilin 2 2.90872
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) 2.89555
TSPAN6 tetraspanin 6 2.69042
NR1H2 nuclear receptor subfamily 1, group H, member 2 2.65705
FZD7 frizzled class receptor 7 2.55052
PPP1R13B protein phosphatase 1, regulatory subunit 13B 2.5324
GATA3 GATA binding protein 3 2.51463
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 2.44499
MARCHF5 membrane associated ring-CH-type finger 5 2.35167
TIAM1 T-cell lymphoma invasion and metastasis 1 2.34157
ZBTB25 zinc finger and BTB domain containing 25 2.23284
SLC35A1 solute carrier family 35 (CMP-sialic acid transporter), member A1 2.207
PARP2 poly (ADP-ribose) polymerase 2 2.2069
CBR3 carbonyl reductase 3 2.17578
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit 2.16491
CCNF cyclin F 2.13137
NOSIP nitric oxide synthase interacting protein 2.12792
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) 2.10545
RAB11FIP1 RAB11 family interacting protein 1 (class I) 2.06851
RAB4A RAB4A, member RAS oncogene family 2.05031
VGLL4 vestigial-like family member 4 2.0438
TMEM187 transmembrane protein 187 2.037
NEIL3 nei endonuclease VIII-like 3 (E. coli) 2.02464
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 2.00589
SOCS2 suppressor of cytokine signaling 2 2.00234

decreased expression

Symbol Name Standardized Value
ZNF586 zinc finger protein 586 -6.20168
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -5.03327
CTSD cathepsin D -4.44985
RAI14 retinoic acid induced 14 -4.10564
TRIB3 tribbles pseudokinase 3 -3.83305
FABP5 fatty acid binding protein 5 (psoriasis-associated) -3.51476
FASTKD5 FAST kinase domains 5 -3.50261
CCDC86 coiled-coil domain containing 86 -3.3828
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -3.36546
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 -3.17605
VDAC1 voltage-dependent anion channel 1 -2.98971
TUBB6 tubulin, beta 6 class V -2.98822
CDC20 cell division cycle 20 -2.98753
HMG20B high mobility group 20B -2.9814
TLR4 toll-like receptor 4 -2.935
EXT1 exostosin glycosyltransferase 1 -2.84933
CCNB2 cyclin B2 -2.83221
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -2.79384
PECR peroxisomal trans-2-enoyl-CoA reductase -2.77721
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -2.70119
DNM1L dynamin 1-like -2.6582
HACD3 3-hydroxyacyl-CoA dehydratase 3 -2.57603
TM9SF3 transmembrane 9 superfamily member 3 -2.45207
FBXO7 F-box protein 7 -2.44505
DNMT1 DNA (cytosine-5-)-methyltransferase 1 -2.42597
MAPK13 mitogen-activated protein kinase 13 -2.3103
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B -2.27766
TENT4A terminal nucleotidyltransferase 4A -2.24361
NOTCH1 notch 1 -2.18668
TCEAL4 transcription elongation factor A (SII)-like 4 -2.18641
STX4 syntaxin 4 -2.18401
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 -2.11452
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -2.07655
ZNRF2 zinc and ring finger 2, E3 ubiquitin protein ligase -2.06924
DENND2D DENN/MADD domain containing 2D -2.01873