CRCGN010_HEPG2_24H:J17 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description DMSO perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

89 genes differentially expressed following the CRCGN010_HEPG2_24H:J17 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 9.42455
ADGRE5 adhesion G protein-coupled receptor E5 5.43053
E2F2 E2F transcription factor 2 5.40683
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 5.26073
UBQLN2 ubiquilin 2 5.17795
EGF epidermal growth factor 5.15316
CDPF1 cysteine-rich, DPF motif domain containing 1 4.37391
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 4.21338
CXCL2 chemokine (C-X-C motif) ligand 2 3.94838
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.83413
LSR lipolysis stimulated lipoprotein receptor 3.73914
ANO1 anoctamin 1, calcium activated chloride channel 3.68761
GSTZ1 glutathione S-transferase zeta 1 3.67062
DENND2D DENN/MADD domain containing 2D 3.58083
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 3.3685
CCL2 chemokine (C-C motif) ligand 2 3.26955
UFM1 ubiquitin-fold modifier 1 3.26273
HMOX1 heme oxygenase 1 3.24363
TNIP1 TNFAIP3 interacting protein 1 3.19436
HLA-DMA major histocompatibility complex, class II, DM alpha 3.11123
CHN1 chimerin 1 3.10308
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 3.07477
SLC35B1 solute carrier family 35, member B1 3.05609
SSBP2 single-stranded DNA binding protein 2 2.78072
GATA2 GATA binding protein 2 2.74124
LCN2 lipocalin 2 2.4988
TREM1 triggering receptor expressed on myeloid cells 1 2.316
TEX10 testis expressed 10 2.28317
CYCS cytochrome c, somatic 2.26312
TMEM106B transmembrane protein 106B 2.17136
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group) 2.15766
PIGP phosphatidylinositol glycan anchor biosynthesis, class P 2.14791
CASP7 caspase 7, apoptosis-related cysteine peptidase 2.139
KLF10 Kruppel-like factor 10 2.07669
TP53 tumor protein p53 2.02339

decreased expression

Symbol Name Standardized Value
MRPS2 mitochondrial ribosomal protein S2 -5.06555
PUF60 poly-U binding splicing factor 60KDa -4.87873
PRCP prolylcarboxypeptidase (angiotensinase C) -4.85154
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -4.82461
TLR4 toll-like receptor 4 -4.63384
LDHD lactate dehydrogenase D -4.58225
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -4.57383
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -4.49235
TM9SF3 transmembrane 9 superfamily member 3 -4.27386
OXA1L oxidase (cytochrome c) assembly 1-like -4.26429
NGRN neugrin, neurite outgrowth associated -4.25924
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa -3.75829
VDAC1 voltage-dependent anion channel 1 -3.71242
PCNA proliferating cell nuclear antigen -3.66755
SNX11 sorting nexin 11 -3.49397
SLC35F2 solute carrier family 35, member F2 -3.45484
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -3.40107
HEATR1 HEAT repeat containing 1 -3.28905
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -3.12428
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked -3.02342
ACAA1 acetyl-CoA acyltransferase 1 -3.00506
ERBB2 erb-b2 receptor tyrosine kinase 2 -3.00326
RGS2 regulator of G-protein signaling 2 -2.57046
CDC25B cell division cycle 25B -2.5394
GNAS GNAS complex locus -2.53244
PROS1 protein S (alpha) -2.52784
CHIC2 cysteine-rich hydrophobic domain 2 -2.48166
CRELD2 cysteine-rich with EGF-like domains 2 -2.39932
EN1 engrailed homeobox 1 -2.37261
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D -2.30011
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -2.28509
LCE2B late cornified envelope 2B -2.28265
MAPK13 mitogen-activated protein kinase 13 -2.2793
TLCD3A TLC domain containing 3A -2.24997
FEZF2 FEZ family zinc finger 2 -2.24859
EIF3E eukaryotic translation initiation factor 3, subunit E -2.16885
KRT17 keratin 17, type I -2.16673
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 -2.15558
DCK deoxycytidine kinase -2.14721
NTSR2 neurotensin receptor 2 -2.13058
TTYH1 tweety family member 1 -2.12896
IL12RB2 interleukin 12 receptor, beta 2 -2.11776
CCNK cyclin K -2.10888
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 -2.10375
SUV39H2 suppressor of variegation 3-9 homolog 2 (Drosophila) -2.09749
PEA15 phosphoprotein enriched in astrocytes 15 -2.08995
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha -2.07169
EXT1 exostosin glycosyltransferase 1 -2.06194
SMPD3 sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II) -2.06043
MSTN myostatin -2.0319
OMG oligodendrocyte myelin glycoprotein -2.01768
LHCGR luteinizing hormone/choriogonadotropin receptor -2.0144
MAOB monoamine oxidase B -2.01383
EXO5 exonuclease 5 -2.00434