CRCGN010_HEPG2_24H:J18 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description DMSO perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

66 genes differentially expressed following the CRCGN010_HEPG2_24H:J18 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
LCN2 lipocalin 2 5.31893
E2F2 E2F transcription factor 2 5.21755
MAP7 microtubule-associated protein 7 5.07778
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 5.00258
UBQLN2 ubiquilin 2 4.80051
PPARG peroxisome proliferator-activated receptor gamma 4.40513
GSTZ1 glutathione S-transferase zeta 1 3.89676
NOSIP nitric oxide synthase interacting protein 3.60681
STIMATE STIM activating enhancer 3.55887
ATP11B ATPase, class VI, type 11B 3.24676
CYCS cytochrome c, somatic 3.12268
CEP57 centrosomal protein 57kDa 3.10231
MYLK myosin light chain kinase 3.09162
CIAO3 cytosolic iron-sulfur assembly component 3 2.9203
GPATCH8 G patch domain containing 8 2.79991
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.6602
KLHL9 kelch-like family member 9 2.60564
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.58795
SSBP2 single-stranded DNA binding protein 2 2.43314
GPR88 G protein-coupled receptor 88 2.1623
ZNF423 zinc finger protein 423 2.11413
SF3A2 splicing factor 3a, subunit 2, 66kDa 2.03407
ANO1 anoctamin 1, calcium activated chloride channel 2.01733

decreased expression

Symbol Name Standardized Value
NUP85 nucleoporin 85kDa -8.31609
CCDC86 coiled-coil domain containing 86 -5.28129
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -5.26004
TRIB3 tribbles pseudokinase 3 -5.07199
ZNF586 zinc finger protein 586 -4.87805
TARBP1 TAR (HIV-1) RNA binding protein 1 -4.7997
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -4.44421
CHMP4B charged multivesicular body protein 4B -3.88867
KCTD2 potassium channel tetramerization domain containing 2 -3.84134
MRPS7 mitochondrial ribosomal protein S7 -3.80039
NGRN neugrin, neurite outgrowth associated -3.7207
TM9SF3 transmembrane 9 superfamily member 3 -3.50077
MRPL58 mitochondrial ribosomal protein L58 -3.4673
PCNA proliferating cell nuclear antigen -3.45282
LLGL2 lethal giant larvae homolog 2 (Drosophila) -3.37529
FGFR4 fibroblast growth factor receptor 4 -3.36681
CCNB2 cyclin B2 -3.1163
NAT9 N-acetyltransferase 9 (GCN5-related, putative) -3.06647
PDHX pyruvate dehydrogenase complex, component X -3.03005
TMEM94 transmembrane protein 94 -2.99507
JPT1 Jupiter microtubule associated homolog 1 -2.80572
LOC124907782 dual specificity protein phosphatase 22 -2.66698
GRB2 growth factor receptor-bound protein 2 -2.6652
PPOX protoporphyrinogen oxidase -2.62616
GNAS GNAS complex locus -2.53457
MAPK13 mitogen-activated protein kinase 13 -2.52042
CDC25B cell division cycle 25B -2.46696
SLC38A12 solute carrier family 38 member 12 -2.46562
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -2.42137
FDXR ferredoxin reductase -2.41393
ATP5PD ATP synthase peripheral stalk subunit d -2.38055
GGA3 golgi-associated, gamma adaptin ear containing, ARF binding protein 3 -2.31348
SAP30BP SAP30 binding protein -2.29488
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.22371
STX4 syntaxin 4 -2.21474
CASKIN2 CASK interacting protein 2 -2.15321
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1 -2.14477
EVPL envoplakin -2.09514
ADI1 acireductone dioxygenase 1 -2.08635
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein -2.06309
TLCD3A TLC domain containing 3A -2.04813
ACOX1 acyl-CoA oxidase 1, palmitoyl -2.01362
NAT10 N-acetyltransferase 10 (GCN5-related) -2.00345