CRCGN010_HEPG2_24H:J23 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 4-nitrosomorpholine 1.31 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

67 genes differentially expressed following the CRCGN010_HEPG2_24H:J23 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MYLK myosin light chain kinase 5.22426
DENND2D DENN/MADD domain containing 2D 5.08059
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 5.06347
ADGRE5 adhesion G protein-coupled receptor E5 5.0009
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) 4.93324
AMDHD2 amidohydrolase domain containing 2 4.87885
PPARG peroxisome proliferator-activated receptor gamma 4.57606
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 4.50326
CCL2 chemokine (C-C motif) ligand 2 4.39673
ABHD6 abhydrolase domain containing 6 3.67029
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 3.64741
H2BC12 H2B clustered histone 12 3.61237
SOCS2 suppressor of cytokine signaling 2 3.54607
CRTAP cartilage associated protein 2.95996
CSK c-src tyrosine kinase 2.95335
SNCA synuclein, alpha (non A4 component of amyloid precursor) 2.66562
CCNF cyclin F 2.62108
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.57733
CXCL2 chemokine (C-X-C motif) ligand 2 2.52023
STIMATE STIM activating enhancer 2.50443
SLC66A3 solute carrier family 66 member 3 2.42194
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 2.37579
ADCYAP1R1 adenylate cyclase activating polypeptide 1 (pituitary) receptor type I 2.35015
NPFFR1 neuropeptide FF receptor 1 2.2853
BHMT betaine--homocysteine S-methyltransferase 2.25134
TBXA2R thromboxane A2 receptor 2.22318
SIGLEC15 sialic acid binding Ig-like lectin 15 2.19335
OSBP2 oxysterol binding protein 2 2.1621
HADHB hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit 2.14355
KIR3DL3 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 3 2.09468
FANCE Fanconi anemia, complementation group E 2.08772
ZNF324B zinc finger protein 324B 2.06557
HSPA8 heat shock 70kDa protein 8 2.06159
RAB11FIP1 RAB11 family interacting protein 1 (class I) 2.05178
GPR176 G protein-coupled receptor 176 2.04623
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.02665
HOXC11 homeobox C11 2.00701

decreased expression

Symbol Name Standardized Value
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -7.01099
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -5.38371
CDC20 cell division cycle 20 -5.33725
TARBP1 TAR (HIV-1) RNA binding protein 1 -5.32512
ITFG1 integrin alpha FG-GAP repeat containing 1 -5.07052
NT5DC2 5'-nucleotidase domain containing 2 -5.04195
TSPAN4 tetraspanin 4 -4.26737
OXA1L oxidase (cytochrome c) assembly 1-like -3.83205
CCNB1 cyclin B1 -3.80595
SLC35F2 solute carrier family 35, member F2 -3.41999
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2 -3.35131
VAT1 vesicle amine transport 1 -3.22199
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -2.97281
MAPK13 mitogen-activated protein kinase 13 -2.92132
TES testin LIM domain protein -2.90078
GNAS GNAS complex locus -2.75305
UBE3C ubiquitin protein ligase E3C -2.71808
CD320 CD320 molecule -2.66115
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -2.26135
FGFR4 fibroblast growth factor receptor 4 -2.18399
FBXL12 F-box and leucine-rich repeat protein 12 -2.17472
CPE carboxypeptidase E -2.17045
CDC25B cell division cycle 25B -2.16465
PHKG2 phosphorylase kinase, gamma 2 (testis) -2.10494
RABAC1 Rab acceptor 1 (prenylated) -2.09161
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -2.09034
NAP1L3 nucleosome assembly protein 1-like 3 -2.07106
MAP9 microtubule-associated protein 9 -2.04364
MCOLN1 mucolipin 1 -2.02808
TSEN2 TSEN2 tRNA splicing endonuclease subunit -2.02481