CRCGN010_HEPG2_24H:K03 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 1,2-dichlorobenzene 10.1 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

54 genes differentially expressed following the CRCGN010_HEPG2_24H:K03 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 10.0
CARMIL1 capping protein regulator and myosin 1 linker 1 8.25874
CXCR4 chemokine (C-X-C motif) receptor 4 5.72341
ADGRE5 adhesion G protein-coupled receptor E5 5.466
AMDHD2 amidohydrolase domain containing 2 5.37832
SYNE2 spectrin repeat containing, nuclear envelope 2 5.10767
ADRB2 adrenoceptor beta 2, surface 4.97575
LCN2 lipocalin 2 4.70412
CXCL2 chemokine (C-X-C motif) ligand 2 4.63355
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.88209
NUP133 nucleoporin 133kDa 3.60619
CHN1 chimerin 1 3.49795
RPP38 ribonuclease P/MRP 38kDa subunit 3.40716
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 3.39864
PRR15L proline rich 15-like 2.93389
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.85292
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.74041
GPATCH8 G patch domain containing 8 2.72885
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta 2.62225
PPARG peroxisome proliferator-activated receptor gamma 2.60971
PRKCH protein kinase C, eta 2.60966
KIF5C kinesin family member 5C 2.38818
CORO1A coronin, actin binding protein, 1A 2.25978
ZFP36 ZFP36 ring finger protein 2.21748
KLRB1 killer cell lectin-like receptor subfamily B, member 1 2.17639
CDK4 cyclin-dependent kinase 4 2.15011
TRPV6 transient receptor potential cation channel, subfamily V, member 6 2.14865
NPDC1 neural proliferation, differentiation and control, 1 2.12308
GZMH granzyme H (cathepsin G-like 2, protein h-CCPX) 2.01844
NOSIP nitric oxide synthase interacting protein 2.0083

decreased expression

Symbol Name Standardized Value
TARBP1 TAR (HIV-1) RNA binding protein 1 -8.3116
VAT1 vesicle amine transport 1 -5.05749
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -4.92815
LDHD lactate dehydrogenase D -4.50665
WASHC4 WASH complex subunit 4 -4.18583
TLCD3A TLC domain containing 3A -3.94532
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -3.64894
SNX11 sorting nexin 11 -3.56826
DCK deoxycytidine kinase -3.5549
PDZD2 PDZ domain containing 2 -3.35023
LAP3 leucine aminopeptidase 3 -3.33452
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.31223
LOC124907782 dual specificity protein phosphatase 22 -3.20024
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -3.09743
NRIP1 nuclear receptor interacting protein 1 -3.0873
TLR4 toll-like receptor 4 -3.04834
PRPF4 pre-mRNA processing factor 4 -2.6311
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.60034
EIF5 eukaryotic translation initiation factor 5 -2.56561
CCNB1 cyclin B1 -2.2641
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -2.2029
MAPK13 mitogen-activated protein kinase 13 -2.19041
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -2.15856
SPAG4 sperm associated antigen 4 -2.05549