CRCGN010_HEPG2_24H:K06 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 1,2-dichlorobenzene 1.26 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

52 genes differentially expressed following the CRCGN010_HEPG2_24H:K06 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
STIMATE STIM activating enhancer 7.54146
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 4.53259
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 3.99178
AMDHD2 amidohydrolase domain containing 2 3.98367
NOTCH1 notch 1 3.87016
BZW2 basic leucine zipper and W2 domains 2 3.66106
HOXA10 homeobox A10 3.37971
MICALL1 MICAL-like 1 3.37849
PRR15L proline rich 15-like 3.37177
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 3.12495
GPER1 G protein-coupled estrogen receptor 1 3.1248
HLA-DMA major histocompatibility complex, class II, DM alpha 3.01014
UBQLN2 ubiquilin 2 2.90102
STK10 serine/threonine kinase 10 2.76762
CDPF1 cysteine-rich, DPF motif domain containing 1 2.70099
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.69415
PLSCR3 phospholipid scramblase 3 2.66679
ATP11B ATPase, class VI, type 11B 2.64181
FZD7 frizzled class receptor 7 2.55952
DIPK1A divergent protein kinase domain 1A 2.37314
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.36055
TNIP1 TNFAIP3 interacting protein 1 2.33217
EPN2 epsin 2 2.32879
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 2.29639
MAP7 microtubule-associated protein 7 2.20887
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 2.20388
GATA2 GATA binding protein 2 2.14329
DYNLT3 dynein, light chain, Tctex-type 3 2.12544
TCFL5 transcription factor-like 5 (basic helix-loop-helix) 2.09311
PIH1D1 PIH1 domain containing 1 2.03241
FCHO1 FCH domain only 1 2.0299
MTMR6 myotubularin related protein 6 2.00437

decreased expression

Symbol Name Standardized Value
GNAS GNAS complex locus -5.13585
NGRN neugrin, neurite outgrowth associated -4.95836
ADI1 acireductone dioxygenase 1 -4.07084
PCNA proliferating cell nuclear antigen -3.99064
THAP11 THAP domain containing 11 -3.8286
PCCB propionyl CoA carboxylase, beta polypeptide -3.5912
DNM1L dynamin 1-like -3.48346
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -3.27716
TRIB3 tribbles pseudokinase 3 -3.04099
LDHD lactate dehydrogenase D -2.90615
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 -2.87399
RGS2 regulator of G-protein signaling 2 -2.86266
TLR4 toll-like receptor 4 -2.74064
PRPF4 pre-mRNA processing factor 4 -2.69901
NRIP1 nuclear receptor interacting protein 1 -2.68164
CRELD2 cysteine-rich with EGF-like domains 2 -2.62289
COG7 component of oligomeric golgi complex 7 -2.52817
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -2.40593
CHIC2 cysteine-rich hydrophobic domain 2 -2.38909
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -2.18288