CRCGN010_HEPG2_24H:K12 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description vorinostat 0.63 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

316 genes differentially expressed following the CRCGN010_HEPG2_24H:K12 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
UBQLN2 ubiquilin 2 10.0
PPARG peroxisome proliferator-activated receptor gamma 10.0
UBE2L6 ubiquitin-conjugating enzyme E2L 6 10.0
FOXO4 forkhead box O4 7.903
CBR1 carbonyl reductase 1 7.59365
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 6.65513
DNM1 dynamin 1 6.54537
ALDOC aldolase C, fructose-bisphosphate 6.4949
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 5.6828
DENND2D DENN/MADD domain containing 2D 5.592
ANO10 anoctamin 10 5.21365
HMG20B high mobility group 20B 5.10859
MVP major vault protein 5.02658
MYC v-myc avian myelocytomatosis viral oncogene homolog 4.83449
LGMN legumain 4.80576
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 4.75168
ABHD6 abhydrolase domain containing 6 4.7051
PLA2G15 phospholipase A2, group XV 4.67669
TIMP2 TIMP metallopeptidase inhibitor 2 4.49215
TCEA2 transcription elongation factor A (SII), 2 4.41136
NUCB2 nucleobindin 2 4.30611
STXBP1 syntaxin binding protein 1 4.15688
CGRRF1 cell growth regulator with ring finger domain 1 4.08407
PRCP prolylcarboxypeptidase (angiotensinase C) 4.07434
DFFA DNA fragmentation factor, 45kDa, alpha polypeptide 3.97443
PFKL phosphofructokinase, liver 3.94504
CHMP6 charged multivesicular body protein 6 3.88482
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 3.83284
SNX7 sorting nexin 7 3.71894
LSR lipolysis stimulated lipoprotein receptor 3.69174
DUSP6 dual specificity phosphatase 6 3.68951
PPP1R13B protein phosphatase 1, regulatory subunit 13B 3.65791
MAPK3 mitogen-activated protein kinase 3 3.62309
H2BC12 H2B clustered histone 12 3.60108
SKIC2 SKI2 subunit of superkiller complex 3.46215
KIF5C kinesin family member 5C 3.45745
DHRS7 dehydrogenase/reductase (SDR family) member 7 3.43022
TUBB6 tubulin, beta 6 class V 3.40796
PLS1 plastin 1 3.40197
AARS1 alanyl-tRNA synthetase 1 3.38324
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 3.27811
CHN1 chimerin 1 3.22342
PTPN12 protein tyrosine phosphatase, non-receptor type 12 3.21657
NOTCH1 notch 1 3.19975
LRP10 low density lipoprotein receptor-related protein 10 3.12318
GSTZ1 glutathione S-transferase zeta 1 3.10274
TXNRD1 thioredoxin reductase 1 3.05664
VAT1 vesicle amine transport 1 3.05042
CIAO3 cytosolic iron-sulfur assembly component 3 3.01911
TMEM50A transmembrane protein 50A 3.00484
IER3 immediate early response 3 2.96673
ARFIP2 ADP-ribosylation factor interacting protein 2 2.96653
INTS3 integrator complex subunit 3 2.90299
PECR peroxisomal trans-2-enoyl-CoA reductase 2.86963
CBR3 carbonyl reductase 3 2.85289
NCOA3 nuclear receptor coactivator 3 2.8276
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5 2.78632
SYNGR3 synaptogyrin 3 2.7651
SEMA6C sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C 2.74515
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 2.72791
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 2.71658
PDLIM1 PDZ and LIM domain 1 2.70075
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 2.68871
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) 2.66773
GET1 guided entry of tail-anchored proteins factor 1 2.65998
CORO1A coronin, actin binding protein, 1A 2.65935
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 2.63817
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 2.6238
PSMA5 proteasome (prosome, macropain) subunit, alpha type, 5 2.62199
VGLL4 vestigial-like family member 4 2.61782
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble 2.59541
COG7 component of oligomeric golgi complex 7 2.5766
ABHD4 abhydrolase domain containing 4 2.57564
DYNLT3 dynein, light chain, Tctex-type 3 2.57085
MUC13 mucin 13, cell surface associated 2.56538
ADGRG1 adhesion G protein-coupled receptor G1 2.55929
MAGEH1 melanoma antigen family H1 2.55833
CNPY4 canopy FGF signaling regulator 4 2.53906
GATD3 glutamine amidotransferase class 1 domain containing 3 2.53455
MMS19 MMS19 nucleotide excision repair homolog (S. cerevisiae) 2.51158
NACAD NAC alpha domain containing 2.46847
RAB3A RAB3A, member RAS oncogene family 2.46228
GPX2 glutathione peroxidase 2 2.45576
HABP4 hyaluronan binding protein 4 2.45411
PRRG1 proline rich Gla (G-carboxyglutamic acid) 1 2.44523
SATB1 SATB homeobox 1 2.43567
DDB2 damage-specific DNA binding protein 2, 48kDa 2.43566
NMT2 N-myristoyltransferase 2 2.43394
GPR137B G protein-coupled receptor 137B 2.43158
TRADD TNFRSF1A-associated via death domain 2.4075
EGR1 early growth response 1 2.40111
PFKP phosphofructokinase, platelet 2.399
TBPL1 TBP-like 1 2.39231
TWF2 twinfilin actin binding protein 2 2.38086
TAC4 tachykinin 4 (hemokinin) 2.3736
GRN granulin 2.36822
DOK4 docking protein 4 2.34123
INPP1 inositol polyphosphate-1-phosphatase 2.34106
PRKCD protein kinase C, delta 2.33573
CALM3 calmodulin 3 (phosphorylase kinase, delta) 2.32882
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 2.31259
FKBP14 FK506 binding protein 14, 22 kDa 2.30992
COL1A1 collagen, type I, alpha 1 2.30497
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 2.28299
GPR162 G protein-coupled receptor 162 2.28294
BMP4 bone morphogenetic protein 4 2.27515
GPATCH8 G patch domain containing 8 2.27329
CDC42 cell division cycle 42 2.27
BAMBI BMP and activin membrane-bound inhibitor 2.24569
HMOX1 heme oxygenase 1 2.23368
PPP4C protein phosphatase 4, catalytic subunit 2.22721
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1) 2.2232
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 2.213
MNAT1 MNAT CDK-activating kinase assembly factor 1 2.20978
CARMIL1 capping protein regulator and myosin 1 linker 1 2.20051
RUVBL1 RuvB-like AAA ATPase 1 2.19967
PPFIA3 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3 2.19043
H2AC6 H2A clustered histone 6 2.18849
ZMIZ1 zinc finger, MIZ-type containing 1 2.17725
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F 2.16462
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1 2.15737
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 2.15508
BCL9 B-cell CLL/lymphoma 9 2.14926
ZW10 zw10 kinetochore protein 2.14501
RABAC1 Rab acceptor 1 (prenylated) 2.1374
ND5 NADH dehydrogenase subunit 5 2.1281
GNB5 guanine nucleotide binding protein (G protein), beta 5 2.1128
RSU1 Ras suppressor protein 1 2.11173
FXYD7 FXYD domain containing ion transport regulator 7 2.10004
FAM171A1 family with sequence similarity 171, member A1 2.09912
TRIB1 tribbles pseudokinase 1 2.09441
EDN1 endothelin 1 2.08952
HLA-E major histocompatibility complex, class I, E 2.08492
CAMLG calcium modulating ligand 2.05935
ATP9A ATPase, class II, type 9A 2.05415
ADGRL1 adhesion G protein-coupled receptor L1 2.04983
RUSF1 RUS family member 1 2.03305
MCOLN1 mucolipin 1 2.03164
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 2.0264
LPAR2 lysophosphatidic acid receptor 2 2.02559
LMTK1 lemur tail kinase 1 2.01695
RHOC ras homolog family member C 2.01694
PYCR1 pyrroline-5-carboxylate reductase 1 2.01136
TMED10 transmembrane emp24-like trafficking protein 10 (yeast) 2.00919
APBB1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) 2.0057
CYCS cytochrome c, somatic 2.00532
BBC3 BCL2 binding component 3 2.0052

decreased expression

Symbol Name Standardized Value
CD320 CD320 molecule -9.09963
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -8.10044
ADI1 acireductone dioxygenase 1 -7.596
CDC20 cell division cycle 20 -7.39822
TCTN1 tectonic family member 1 -7.12772
TLR4 toll-like receptor 4 -5.86855
TCERG1 transcription elongation regulator 1 -5.64384
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) -5.43593
KEAP1 kelch-like ECH-associated protein 1 -5.35726
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -5.33169
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -5.30982
FAIM Fas apoptotic inhibitory molecule -5.09874
NUP85 nucleoporin 85kDa -5.07134
RFC2 replication factor C (activator 1) 2, 40kDa -5.0584
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -4.998
PGM1 phosphoglucomutase 1 -4.99052
MELK maternal embryonic leucine zipper kinase -4.92105
ISOC1 isochorismatase domain containing 1 -4.8629
MSRA methionine sulfoxide reductase A -4.77081
TLCD3A TLC domain containing 3A -4.76114
RPIA ribose 5-phosphate isomerase A -4.66689
STAP2 signal transducing adaptor family member 2 -4.53923
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -4.46531
CCNA2 cyclin A2 -4.38031
DNM1L dynamin 1-like -4.33747
TMEM109 transmembrane protein 109 -4.32061
LRRC41 leucine rich repeat containing 41 -4.30352
CHEK1 checkpoint kinase 1 -4.25682
UBE2C ubiquitin-conjugating enzyme E2C -4.11236
TRIB3 tribbles pseudokinase 3 -4.0787
GTPBP8 GTP-binding protein 8 (putative) -4.04294
DERA deoxyribose-phosphate aldolase (putative) -4.006
CCNB2 cyclin B2 -3.9692
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.9183
SACM1L SAC1 suppressor of actin mutations 1-like (yeast) -3.87622
TATDN2 TatD DNase domain containing 2 -3.7949
SOAT2 sterol O-acyltransferase 2 -3.75228
PARP1 poly (ADP-ribose) polymerase 1 -3.69815
HACD3 3-hydroxyacyl-CoA dehydratase 3 -3.69659
NNT nicotinamide nucleotide transhydrogenase -3.67434
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -3.59739
FOXM1 forkhead box M1 -3.52572
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 -3.51125
RBM15B RNA binding motif protein 15B -3.38549
SPAG7 sperm associated antigen 7 -3.35407
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -3.32468
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -3.29271
BDH1 3-hydroxybutyrate dehydrogenase, type 1 -3.2778
CDC25A cell division cycle 25A -3.27394
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -3.15099
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha -3.13858
RRAGA Ras-related GTP binding A -3.10378
DNMT1 DNA (cytosine-5-)-methyltransferase 1 -3.07672
CHMP4B charged multivesicular body protein 4B -3.03704
PLK1 polo-like kinase 1 -3.02449
ECH1 enoyl CoA hydratase 1, peroxisomal -3.01697
KDM3A lysine (K)-specific demethylase 3A -2.98933
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit -2.92745
TOR1A torsin family 1, member A (torsin A) -2.92229
CDC25B cell division cycle 25B -2.89759
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -2.8931
LOC124907782 dual specificity protein phosphatase 22 -2.87979
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1 -2.86463
POLA2 polymerase (DNA directed), alpha 2, accessory subunit -2.8594
DPP3 dipeptidyl-peptidase 3 -2.8446
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase -2.81324
NT5DC2 5'-nucleotidase domain containing 2 -2.81162
HADH hydroxyacyl-CoA dehydrogenase -2.807
LDHD lactate dehydrogenase D -2.77064
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B -2.70614
MLC1 megalencephalic leukoencephalopathy with subcortical cysts 1 -2.68746
AURKB aurora kinase B -2.65369
PMM2 phosphomannomutase 2 -2.64711
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B -2.64243
CASC3 cancer susceptibility candidate 3 -2.63709
SMC4 structural maintenance of chromosomes 4 -2.62734
GALE UDP-galactose-4-epimerase -2.6256
CPNE3 copine III -2.60665
ZDHHC6 zinc finger, DHHC-type containing 6 -2.60651
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 -2.59419
DCK deoxycytidine kinase -2.58237
TIMELESS timeless circadian clock -2.56724
MYH3 myosin, heavy chain 3, skeletal muscle, embryonic -2.56597
KIF14 kinesin family member 14 -2.54267
CDC6 cell division cycle 6 -2.53788
PPIH peptidylprolyl isomerase H (cyclophilin H) -2.52971
PROS1 protein S (alpha) -2.5192
ACAA1 acetyl-CoA acyltransferase 1 -2.50291
CDK4 cyclin-dependent kinase 4 -2.49073
PHF2 PHD finger protein 2 -2.48829
SPAG4 sperm associated antigen 4 -2.44544
MAPK13 mitogen-activated protein kinase 13 -2.44507
GCHFR GTP cyclohydrolase I feedback regulator -2.42372
TYK2 tyrosine kinase 2 -2.41598
KRI1 KRI1 homolog (S. cerevisiae) -2.40973
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor -2.36909
NRIP1 nuclear receptor interacting protein 1 -2.36636
PHKA1 phosphorylase kinase, alpha 1 (muscle) -2.36282
POLR1A polymerase (RNA) I polypeptide A, 194kDa -2.36125
RXYLT1 ribitol xylosyltransferase 1 -2.35601
VAV3 vav 3 guanine nucleotide exchange factor -2.34682
CENPS-CORT CENPS-CORT readthrough -2.32679
MYL1 myosin, light chain 1, alkali; skeletal, fast -2.31329
MEPCE methylphosphate capping enzyme -2.31015
SLC6A16 solute carrier family 6, member 16 -2.30203
GUF1 GUF1 GTPase homolog (S. cerevisiae) -2.29254
CENPU centromere protein U -2.26944
BIRC5 baculoviral IAP repeat containing 5 -2.26276
BARD1 BRCA1 associated RING domain 1 -2.25219
CBX5 chromobox homolog 5 -2.25203
OIP5 Opa interacting protein 5 -2.23402
FBXO7 F-box protein 7 -2.23349
MTARC2 mitochondrial amidoxime reducing component 2 -2.22737
BMAL2 basic helix-loop-helix ARNT like 2 -2.22479
NCBP3 nuclear cap binding subunit 3 -2.22206
TERT telomerase reverse transcriptase -2.20683
PUF60 poly-U binding splicing factor 60KDa -2.20235
MYBPC2 myosin binding protein C, fast type -2.20116
EXO1 exonuclease 1 -2.19403
GINS2 GINS complex subunit 2 (Psf2 homolog) -2.19347
ING3 inhibitor of growth family, member 3 -2.18317
FGFR4 fibroblast growth factor receptor 4 -2.17802
PLOD3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 -2.17151
ZBED1 zinc finger, BED-type containing 1 -2.16946
KLHL21 kelch-like family member 21 -2.16885
HMGB2 high mobility group box 2 -2.1627
ZBTB35 zinc finger and BTB domain containing 35 -2.15987
INSIG1 insulin induced gene 1 -2.15765
PLA1A phospholipase A1 member A -2.15666
DENND4B DENN/MADD domain containing 4B -2.15396
ARHGEF26 Rho guanine nucleotide exchange factor (GEF) 26 -2.14536
GNAS GNAS complex locus -2.13981
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -2.13146
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta -2.13029
SQOR sulfide quinone oxidoreductase -2.12907
ENO3 enolase 3 (beta, muscle) -2.12852
MYL11 myosin light chain 11 -2.12681
KRT34 keratin 34, type I -2.12636
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -2.12612
DEPDC1 DEP domain containing 1 -2.11556
PCCB propionyl CoA carboxylase, beta polypeptide -2.11073
NUP62 nucleoporin 62kDa -2.10951
NDUFAF1 NADH dehydrogenase (ubiquinone) complex I, assembly factor 1 -2.10878
ATF5 activating transcription factor 5 -2.10474
EIF5 eukaryotic translation initiation factor 5 -2.10148
CKM creatine kinase, muscle -2.09825
MTHFD2L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like -2.09647
ELAC2 elaC ribonuclease Z 2 -2.0874
TEAD4 TEA domain family member 4 -2.08605
TIPIN TIMELESS interacting protein -2.08008
AMT aminomethyltransferase -2.07847
CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3 -2.07393
MYLK myosin light chain kinase -2.07041
KAT5 K(lysine) acetyltransferase 5 -2.06411
EFHD1 EF-hand domain family, member D1 -2.05705
NUP88 nucleoporin 88kDa -2.0533
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9 -2.05244
ECHDC1 ethylmalonyl-CoA decarboxylase 1 -2.04324
SGCA sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein) -2.03753
FANCG Fanconi anemia, complementation group G -2.03305
KCNK2 potassium channel, two pore domain subfamily K, member 2 -2.02883
MRPS16 mitochondrial ribosomal protein S16 -2.0281
GRIA4 glutamate receptor, ionotropic, AMPA 4 -2.02591
EXOSC8 exosome component 8 -2.02538
ICAM3 intercellular adhesion molecule 3 -2.02247
TFDP1 transcription factor Dp-1 -2.01472
CDK1 cyclin-dependent kinase 1 -2.00955
INPPL1 inositol polyphosphate phosphatase-like 1 -2.00782
AFM afamin -2.00366