CRCGN010_HEPG2_24H:K14 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description lithocholic-acid 19.9 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

54 genes differentially expressed following the CRCGN010_HEPG2_24H:K14 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 4.89223
RPP38 ribonuclease P/MRP 38kDa subunit 4.37482
LCN2 lipocalin 2 4.28447
PPARG peroxisome proliferator-activated receptor gamma 4.26205
UBQLN2 ubiquilin 2 4.04945
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 4.04341
MYLK myosin light chain kinase 3.9559
NR1H2 nuclear receptor subfamily 1, group H, member 2 3.95068
CXCL2 chemokine (C-X-C motif) ligand 2 3.93485
PLSCR1 phospholipid scramblase 1 3.89921
CBR3 carbonyl reductase 3 3.87249
CIAO3 cytosolic iron-sulfur assembly component 3 3.87103
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 3.8703
AMDHD2 amidohydrolase domain containing 2 3.8554
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 3.71396
NOTCH1 notch 1 3.50705
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.38825
TIAM1 T-cell lymphoma invasion and metastasis 1 3.23597
HLA-DMA major histocompatibility complex, class II, DM alpha 3.09219
GPATCH8 G patch domain containing 8 2.95616
RRAGA Ras-related GTP binding A 2.89958
TRIM13 tripartite motif containing 13 2.83482
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 2.66654
CCNH cyclin H 2.64739
ABHD4 abhydrolase domain containing 4 2.64166
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.57976
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 2.5112
LHFPL6 LHFPL tetraspan subfamily member 6 2.43235
LPAR2 lysophosphatidic acid receptor 2 2.4052
CTSL cathepsin L 2.18311
HLA-DRA major histocompatibility complex, class II, DR alpha 2.12541
PLSCR3 phospholipid scramblase 3 2.10636
POLG2 polymerase (DNA directed), gamma 2, accessory subunit 2.098

decreased expression

Symbol Name Standardized Value
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -5.9031
TUBB6 tubulin, beta 6 class V -4.80142
SLC35F2 solute carrier family 35, member F2 -4.75229
PECR peroxisomal trans-2-enoyl-CoA reductase -4.65279
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -4.51608
CDC20 cell division cycle 20 -4.42003
ZW10 zw10 kinetochore protein -4.21736
TLR4 toll-like receptor 4 -4.18312
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.13434
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -4.07206
LDHD lactate dehydrogenase D -3.96769
NRIP1 nuclear receptor interacting protein 1 -3.94087
SOAT2 sterol O-acyltransferase 2 -2.20243
SNX11 sorting nexin 11 -2.17135
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -2.10696
TM9SF3 transmembrane 9 superfamily member 3 -2.08208
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) -2.0642
ACKR5 atypical chemokine receptor 5 -2.06354
APBA1 amyloid beta (A4) precursor protein-binding, family A, member 1 -2.05973
CRELD2 cysteine-rich with EGF-like domains 2 -2.05465
KLRC4-KLRK1 KLRC4-KLRK1 readthrough -2.05253