CRCGN010_HEPG2_24H:K17 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description lithocholic-acid 2.49 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

63 genes differentially expressed following the CRCGN010_HEPG2_24H:K17 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
GSTZ1 glutathione S-transferase zeta 1 6.24102
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 6.22007
GPER1 G protein-coupled estrogen receptor 1 5.67568
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 4.73367
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 3.88381
LPAR2 lysophosphatidic acid receptor 2 3.76704
CYCS cytochrome c, somatic 3.6229
CHN1 chimerin 1 3.61082
NOSIP nitric oxide synthase interacting protein 3.50108
BACE2 beta-site APP-cleaving enzyme 2 3.49634
PPARG peroxisome proliferator-activated receptor gamma 3.32519
CHMP6 charged multivesicular body protein 6 3.2616
UBQLN2 ubiquilin 2 3.25926
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 3.11158
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.93948
ADRB2 adrenoceptor beta 2, surface 2.81461
STK10 serine/threonine kinase 10 2.7732
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.52447
GARRE1 granule associated Rac and RHOG effector 1 2.49698
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 2.23954
GALK1 galactokinase 1 2.21402
PFKL phosphofructokinase, liver 2.17056
ISG15 ISG15 ubiquitin-like modifier 2.12243
CIAO3 cytosolic iron-sulfur assembly component 3 2.10512
SKIC2 SKI2 subunit of superkiller complex 2.04744
APRT adenine phosphoribosyltransferase 2.02505

decreased expression

Symbol Name Standardized Value
VAT1 vesicle amine transport 1 -7.02085
LDHD lactate dehydrogenase D -7.01078
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -6.80171
KDM3A lysine (K)-specific demethylase 3A -6.71259
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -6.07421
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -5.43858
NRIP1 nuclear receptor interacting protein 1 -4.21713
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -4.17293
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -4.05023
OXA1L oxidase (cytochrome c) assembly 1-like -4.03497
GTPBP8 GTP-binding protein 8 (putative) -3.87398
PCCB propionyl CoA carboxylase, beta polypeptide -3.81849
RPIA ribose 5-phosphate isomerase A -3.80303
CTSD cathepsin D -3.75624
DNM1L dynamin 1-like -3.68853
ITFG1 integrin alpha FG-GAP repeat containing 1 -3.60975
ZMIZ1 zinc finger, MIZ-type containing 1 -3.43396
NT5DC2 5'-nucleotidase domain containing 2 -3.29931
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.11144
CCNB2 cyclin B2 -3.00342
ZNF586 zinc finger protein 586 -2.94115
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -2.8603
CAB39 calcium binding protein 39 -2.77738
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -2.51744
MAPK13 mitogen-activated protein kinase 13 -2.36938
TM9SF3 transmembrane 9 superfamily member 3 -2.36257
H2BC21 H2B clustered histone 21 -2.32259
PTPRK protein tyrosine phosphatase, receptor type, K -2.25532
NOTCH1 notch 1 -2.22429
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) -2.21566
CD58 CD58 molecule -2.17219
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked -2.1647
PLA2G15 phospholipase A2, group XV -2.13571
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -2.09031
NCKIPSD NCK interacting protein with SH3 domain -2.04528
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) -2.02264
CLTC clathrin, heavy chain (Hc) -2.00581