CRCGN010_HEPG2_24H:K22 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description p,p'-dichlorodiphenyl sulfone 5.05 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

79 genes differentially expressed following the CRCGN010_HEPG2_24H:K22 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
LCN2 lipocalin 2 5.65464
CDPF1 cysteine-rich, DPF motif domain containing 1 4.93127
PNKP polynucleotide kinase 3'-phosphatase 4.7596
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 4.60008
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.53806
IL1B interleukin 1, beta 4.51723
NOTCH1 notch 1 4.48367
MSRA methionine sulfoxide reductase A 4.2177
MAP7 microtubule-associated protein 7 3.98456
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.93881
PPARG peroxisome proliferator-activated receptor gamma 3.93678
CXCL2 chemokine (C-X-C motif) ligand 2 3.5294
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 3.33435
LPAR2 lysophosphatidic acid receptor 2 3.24812
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 3.16153
SSBP2 single-stranded DNA binding protein 2 2.99373
PLSCR1 phospholipid scramblase 1 2.91003
HSPA8 heat shock 70kDa protein 8 2.86438
PMM2 phosphomannomutase 2 2.77395
GADD45A growth arrest and DNA-damage-inducible, alpha 2.66077
DIPK1A divergent protein kinase domain 1A 2.58542
GTF2F2 general transcription factor IIF, polypeptide 2, 30kDa 2.57933
SATB1 SATB homeobox 1 2.56171
IGHMBP2 immunoglobulin mu binding protein 2 2.50251
G0S2 G0/G1 switch 2 2.42301
MRPL12 mitochondrial ribosomal protein L12 2.41179
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta 2.28358
MGA MGA, MAX dimerization protein 2.19813
SIRT3 sirtuin 3 2.19419
RIC8A RIC8 guanine nucleotide exchange factor A 2.10433
ZNF276 zinc finger protein 276 2.10118
ZFP36 ZFP36 ring finger protein 2.10036
TREM1 triggering receptor expressed on myeloid cells 1 2.00828

decreased expression

Symbol Name Standardized Value
GNAS GNAS complex locus -6.41591
CCNB2 cyclin B2 -5.28631
HACD3 3-hydroxyacyl-CoA dehydratase 3 -5.25868
TRIB3 tribbles pseudokinase 3 -4.99791
TARBP1 TAR (HIV-1) RNA binding protein 1 -4.77637
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -4.53328
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -4.48488
TLR4 toll-like receptor 4 -4.38622
RPS4Y1 ribosomal protein S4, Y-linked 1 -4.1743
NGRN neugrin, neurite outgrowth associated -4.02586
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.00009
CDC20 cell division cycle 20 -3.94265
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked -3.91542
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2 -3.67845
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -3.61315
PPOX protoporphyrinogen oxidase -3.18711
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -3.13652
SESN1 sestrin 1 -3.06602
CAMTA1 calmodulin binding transcription activator 1 -2.94735
ZW10 zw10 kinetochore protein -2.88724
ACAA1 acetyl-CoA acyltransferase 1 -2.69095
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 -2.64383
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -2.6389
SLC30A10 solute carrier family 30, member 10 -2.61437
RAI14 retinoic acid induced 14 -2.5841
DHX16 DEAH (Asp-Glu-Ala-His) box polypeptide 16 -2.3947
HPS6 Hermansky-Pudlak syndrome 6 -2.35144
SENP6 SUMO1/sentrin specific peptidase 6 -2.29062
BTBD8 BTB (POZ) domain containing 8 -2.2752
SSTR2 somatostatin receptor 2 -2.2728
CYP7B1 cytochrome P450, family 7, subfamily B, polypeptide 1 -2.23289
NCAM2 neural cell adhesion molecule 2 -2.16812
RSRC1 arginine/serine-rich coiled-coil 1 -2.13993
PSMA4 proteasome (prosome, macropain) subunit, alpha type, 4 -2.13565
CRYGB crystallin, gamma B -2.11272
RBMY1J RNA binding motif protein, Y-linked, family 1, member J -2.08012
AGPAT1 1-acylglycerol-3-phosphate O-acyltransferase 1 -2.0784
TMEM158 transmembrane protein 158 (gene/pseudogene) -2.07162
ST8SIA1 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 -2.06238
NELFE negative elongation factor complex member E -2.06108
CYP3A43 cytochrome P450, family 3, subfamily A, polypeptide 43 -2.05797
ZFY zinc finger protein, Y-linked -2.03859
PRH1-TAS2R14 PRH1-TAS2R14 readthrough -2.03778
RRAGB Ras-related GTP binding B -2.03524
PYHIN1 pyrin and HIN domain family, member 1 -2.02807
KIAA0408 KIAA0408 -2.00869