CRCGN010_HEPG2_24H:L05 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description edaravone 2.51 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

56 genes differentially expressed following the CRCGN010_HEPG2_24H:L05 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PNKP polynucleotide kinase 3'-phosphatase 7.34518
MYLK myosin light chain kinase 7.2617
DYNLT3 dynein, light chain, Tctex-type 3 5.47913
ADGRE5 adhesion G protein-coupled receptor E5 4.90297
RPP38 ribonuclease P/MRP 38kDa subunit 4.83148
STK10 serine/threonine kinase 10 4.69409
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.49354
PPARG peroxisome proliferator-activated receptor gamma 4.24723
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 3.63676
GPER1 G protein-coupled estrogen receptor 1 3.62956
MEST mesoderm specific transcript 3.44366
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) 3.439
PFKL phosphofructokinase, liver 3.31479
ADO 2-aminoethanethiol (cysteamine) dioxygenase 3.00203
GSTZ1 glutathione S-transferase zeta 1 2.90317
CHN1 chimerin 1 2.81648
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.79248
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.69628
ZNF589 zinc finger protein 589 2.64084
CSK c-src tyrosine kinase 2.60123
AMDHD2 amidohydrolase domain containing 2 2.53397
ATP11B ATPase, class VI, type 11B 2.38524
MTG1 mitochondrial ribosome-associated GTPase 1 2.36572
LOC122526780 uncharacterized LOC122526780 2.35566
ANO1 anoctamin 1, calcium activated chloride channel 2.35465
PWP2 PWP2 periodic tryptophan protein homolog (yeast) 2.3357
PSME2 proteasome (prosome, macropain) activator subunit 2 (PA28 beta) 2.28776
BAD BCL2-associated agonist of cell death 2.24756
GSDMD gasdermin D 2.13971
CCL2 chemokine (C-C motif) ligand 2 2.02385
UBQLN2 ubiquilin 2 2.01869
BAX BCL2-associated X protein 2.01671
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.01313

decreased expression

Symbol Name Standardized Value
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -7.62312
LDHD lactate dehydrogenase D -7.25023
GNAS GNAS complex locus -6.83978
RFC2 replication factor C (activator 1) 2, 40kDa -4.82399
HSPB1 heat shock 27kDa protein 1 -3.80828
OXA1L oxidase (cytochrome c) assembly 1-like -3.70755
SLC35F2 solute carrier family 35, member F2 -3.19183
TXNRD1 thioredoxin reductase 1 -2.78112
DNM1L dynamin 1-like -2.7601
TM9SF3 transmembrane 9 superfamily member 3 -2.73656
CDC20 cell division cycle 20 -2.73502
ADI1 acireductone dioxygenase 1 -2.69605
BLCAP bladder cancer associated protein -2.50272
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 -2.26949
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.26498
STAT1 signal transducer and activator of transcription 1, 91kDa -2.25072
REEP5 receptor accessory protein 5 -2.22304
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -2.22074
DHRS7 dehydrogenase/reductase (SDR family) member 7 -2.21391
KDM3A lysine (K)-specific demethylase 3A -2.15013
GDF15 growth differentiation factor 15 -2.11258
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.03692
RBM15B RNA binding motif protein 15B -2.01581