CRCGN010_HEPG2_24H:L08 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description phthalamide 20.1 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

40 genes differentially expressed following the CRCGN010_HEPG2_24H:L08 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MYLK myosin light chain kinase 3.84652
GPER1 G protein-coupled estrogen receptor 1 3.27548
PMM2 phosphomannomutase 2 3.21317
HLA-DMA major histocompatibility complex, class II, DM alpha 3.00991
NOSIP nitric oxide synthase interacting protein 3.00235
BPHL biphenyl hydrolase-like (serine hydrolase) 2.97314
DIPK1A divergent protein kinase domain 1A 2.68272
MAP7 microtubule-associated protein 7 2.67748
CD40 CD40 molecule, TNF receptor superfamily member 5 2.66364
HSPA1A heat shock 70kDa protein 1A 2.48907
STXBP2 syntaxin binding protein 2 2.43015
BAD BCL2-associated agonist of cell death 2.28164
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.25981
HPRT1 hypoxanthine phosphoribosyltransferase 1 2.06812
DCTPP1 dCTP pyrophosphatase 1 2.0519
RAB31 RAB31, member RAS oncogene family 2.04386
FCHO1 FCH domain only 1 2.04169

decreased expression

Symbol Name Standardized Value
OXA1L oxidase (cytochrome c) assembly 1-like -6.52547
LDHD lactate dehydrogenase D -5.87241
CDC20 cell division cycle 20 -5.73694
CASP7 caspase 7, apoptosis-related cysteine peptidase -4.98848
DHRS7 dehydrogenase/reductase (SDR family) member 7 -4.73708
VDAC1 voltage-dependent anion channel 1 -4.27015
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -4.17245
GDF15 growth differentiation factor 15 -3.99368
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase -3.78367
TXNRD1 thioredoxin reductase 1 -3.70248
FBXL12 F-box and leucine-rich repeat protein 12 -3.65443
GNAS GNAS complex locus -3.52523
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -3.47529
TLR4 toll-like receptor 4 -3.0413
CRELD2 cysteine-rich with EGF-like domains 2 -2.31742
GET1 guided entry of tail-anchored proteins factor 1 -2.20924
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -2.13367
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) -2.09622
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked -2.07784
PRPF4 pre-mRNA processing factor 4 -2.07382
RBM15B RNA binding motif protein 15B -2.05484
SSBP2 single-stranded DNA binding protein 2 -2.03764
NGRN neugrin, neurite outgrowth associated -2.03172