CRCGN010_HEPG2_24H:L10 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description phthalamide 5.02 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

57 genes differentially expressed following the CRCGN010_HEPG2_24H:L10 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MAP7 microtubule-associated protein 7 5.28476
CSK c-src tyrosine kinase 4.0961
CIAO3 cytosolic iron-sulfur assembly component 3 3.41597
CXCL2 chemokine (C-X-C motif) ligand 2 3.37163
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 3.34127
ADGRE5 adhesion G protein-coupled receptor E5 3.3099
MYLK myosin light chain kinase 3.2513
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) 3.2492
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble 2.96045
NOTCH1 notch 1 2.86853
NOSIP nitric oxide synthase interacting protein 2.79473
HLA-DMA major histocompatibility complex, class II, DM alpha 2.74083
NMU neuromedin U 2.44423
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 2.42223
IDE insulin-degrading enzyme 2.36144
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.24087
PRR15L proline rich 15-like 2.2363
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 2.06223
PLSCR3 phospholipid scramblase 3 2.06145

decreased expression

Symbol Name Standardized Value
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -6.6245
ZNF586 zinc finger protein 586 -5.80833
TLR4 toll-like receptor 4 -5.02697
GNAS GNAS complex locus -4.4911
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -4.34053
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -4.1371
MRPS2 mitochondrial ribosomal protein S2 -3.58313
RPN1 ribophorin I -3.48677
FASTKD5 FAST kinase domains 5 -3.36967
RPS4Y1 ribosomal protein S4, Y-linked 1 -3.33333
ADI1 acireductone dioxygenase 1 -3.21583
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -3.2001
VAT1 vesicle amine transport 1 -3.02577
TLCD3A TLC domain containing 3A -3.00117
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.94058
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked -2.93975
CCNB2 cyclin B2 -2.9353
TARBP1 TAR (HIV-1) RNA binding protein 1 -2.80773
HTATSF1 HIV-1 Tat specific factor 1 -2.72345
CHMP4B charged multivesicular body protein 4B -2.71397
PPOX protoporphyrinogen oxidase -2.58903
FGFR4 fibroblast growth factor receptor 4 -2.50285
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -2.3135
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -2.27233
FKRP fukutin related protein -2.25113
PLA2G15 phospholipase A2, group XV -2.22343
ST8SIA1 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 -2.22253
TBX4 T-box 4 -2.14793
IL23A interleukin 23, alpha subunit p19 -2.14103
SQLE squalene epoxidase -2.08939
MSMO1 methylsterol monooxygenase 1 -2.08593
BEAN1 brain expressed, associated with NEDD4, 1 -2.0804
ANKRD44 ankyrin repeat domain 44 -2.07963
CNTN6 contactin 6 -2.06073
CCDC102B coiled-coil domain containing 102B -2.0353
EXO5 exonuclease 5 -2.0217
SLC61A1 solute carrier family 61 member 1 -2.0209
ZFP69B ZFP69 zinc finger protein B -2.01073