CRCGN010_HEPG2_24H:L17 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description iq 2.4 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

74 genes differentially expressed following the CRCGN010_HEPG2_24H:L17 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 6.96145
STK10 serine/threonine kinase 10 6.35944
GPATCH8 G patch domain containing 8 6.04308
MAP7 microtubule-associated protein 7 4.89518
CAPN1 calpain 1, (mu/I) large subunit 4.0454
STAP2 signal transducing adaptor family member 2 3.74351
MNAT1 MNAT CDK-activating kinase assembly factor 1 3.71159
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 3.59386
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 3.32061
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 3.31584
UBQLN2 ubiquilin 2 3.30452
E2F2 E2F transcription factor 2 3.26449
PPARG peroxisome proliferator-activated receptor gamma 3.14325
CXCL2 chemokine (C-X-C motif) ligand 2 3.11274
CHMP6 charged multivesicular body protein 6 3.10918
NOSIP nitric oxide synthase interacting protein 3.04115
TATDN2 TatD DNase domain containing 2 2.88257
C2CD2 C2 calcium-dependent domain containing 2 2.87453
RPL39L ribosomal protein L39-like 2.84639
HDGFL3 HDGF like 3 2.76519
PMM2 phosphomannomutase 2 2.70678
ABHD4 abhydrolase domain containing 4 2.68711
HLA-DMA major histocompatibility complex, class II, DM alpha 2.48816
NOTCH1 notch 1 2.48463
SIRT3 sirtuin 3 2.42675
HLA-DRA major histocompatibility complex, class II, DR alpha 2.37691
SFTPB surfactant protein B 2.37353
GOLGA8N golgin A8 family, member N 2.35743
KDM5A lysine (K)-specific demethylase 5A 2.34394
LCN2 lipocalin 2 2.30075
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 2.29935
PPIC peptidylprolyl isomerase C (cyclophilin C) 2.29512
NME2 NME/NM23 nucleoside diphosphate kinase 2 2.20257
RXYLT1 ribitol xylosyltransferase 1 2.14916
RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4 2.10707
LAMP5 lysosomal-associated membrane protein family, member 5 2.09983
AMZ2 archaelysin family metallopeptidase 2 2.08566
PLSCR3 phospholipid scramblase 3 2.08407
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 2.07132
NFU1 NFU1 iron-sulfur cluster scaffold 2.06222
PGAP2 post-GPI attachment to proteins 2 2.06186
QPRT quinolinate phosphoribosyltransferase 2.05133

decreased expression

Symbol Name Standardized Value
TLR4 toll-like receptor 4 -7.54454
LDHD lactate dehydrogenase D -6.53298
CCNB1 cyclin B1 -3.93406
CCDC86 coiled-coil domain containing 86 -3.92732
UGDH UDP-glucose 6-dehydrogenase -3.91831
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.68412
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -3.59154
KDM3A lysine (K)-specific demethylase 3A -3.38447
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -3.33487
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -3.28268
PCNA proliferating cell nuclear antigen -3.09023
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -3.07314
TSPAN4 tetraspanin 4 -2.94831
CASP7 caspase 7, apoptosis-related cysteine peptidase -2.87907
CCNB2 cyclin B2 -2.86385
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -2.81087
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.54847
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -2.51334
WDR7 WD repeat domain 7 -2.39296
ADI1 acireductone dioxygenase 1 -2.38819
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1 -2.27029
ZNF586 zinc finger protein 586 -2.21756
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -2.20011
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) -2.10326
CTNND1 catenin (cadherin-associated protein), delta 1 -2.07568
HYOU1 hypoxia up-regulated 1 -2.07306
EPHB6 EPH receptor B6 -2.06021
TTLL12 tubulin tyrosine ligase-like family member 12 -2.05469
FOXE1 forkhead box E1 -2.04265
NABP1 nucleic acid binding protein 1 -2.04172
OSBPL11 oxysterol binding protein-like 11 -2.0369
PSMD8 proteasome (prosome, macropain) 26S subunit, non-ATPase, 8 -2.01899