CRCGN010_HEPG2_24H:L18 Gene Set
Genes
50 genes differentially expressed following the CRCGN010_HEPG2_24H:L18 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
increased expression
| Symbol |
Name |
Standardized Value |
|
PNKP
|
polynucleotide kinase 3'-phosphatase
|
6.61049
|
|
GNAI1
|
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
|
5.58978
|
|
CSK
|
c-src tyrosine kinase
|
5.01526
|
|
NOTCH1
|
notch 1
|
4.70841
|
|
CLPX
|
caseinolytic mitochondrial matrix peptidase chaperone subunit
|
4.67613
|
|
CCDC92
|
coiled-coil domain containing 92
|
4.60381
|
|
P4HTM
|
prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
|
3.90886
|
|
PAF1
|
Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae)
|
3.85765
|
|
FZD7
|
frizzled class receptor 7
|
3.66737
|
|
VGLL4
|
vestigial-like family member 4
|
3.49073
|
|
MOK
|
MOK protein kinase
|
3.2328
|
|
SORBS3
|
sorbin and SH3 domain containing 3
|
3.03686
|
|
ZFP36
|
ZFP36 ring finger protein
|
3.03532
|
|
LAGE3
|
L antigen family, member 3
|
2.76828
|
|
IKBKE
|
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
|
2.74923
|
|
CHEK2
|
checkpoint kinase 2
|
2.69933
|
|
GATA3
|
GATA binding protein 3
|
2.34426
|
|
CGRRF1
|
cell growth regulator with ring finger domain 1
|
2.33594
|
|
FSD1
|
fibronectin type III and SPRY domain containing 1
|
2.32804
|
|
JPT2
|
Jupiter microtubule associated homolog 2
|
2.21959
|
|
PDLIM1
|
PDZ and LIM domain 1
|
2.17194
|
|
DCUN1D4
|
DCN1, defective in cullin neddylation 1, domain containing 4
|
2.17175
|
|
BIRC2
|
baculoviral IAP repeat containing 2
|
2.1584
|
|
PLS3
|
plastin 3
|
2.09787
|
|
CHN1
|
chimerin 1
|
2.0295
|
|
COMMD8
|
COMM domain containing 8
|
2.01171
|
|
LCN2
|
lipocalin 2
|
2.01069
|
decreased expression
| Symbol |
Name |
Standardized Value |
|
IDH1
|
isocitrate dehydrogenase 1 (NADP+), soluble
|
-6.64495
|
|
TARBP1
|
TAR (HIV-1) RNA binding protein 1
|
-6.0089
|
|
CCNB2
|
cyclin B2
|
-5.97317
|
|
ZNF586
|
zinc finger protein 586
|
-4.97602
|
|
DHRS7
|
dehydrogenase/reductase (SDR family) member 7
|
-4.62557
|
|
ST6GALNAC2
|
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
|
-4.60234
|
|
HSD17B11
|
hydroxysteroid (17-beta) dehydrogenase 11
|
-4.57328
|
|
CCDC86
|
coiled-coil domain containing 86
|
-4.05352
|
|
TLCD3A
|
TLC domain containing 3A
|
-3.9034
|
|
GNAS
|
GNAS complex locus
|
-3.79073
|
|
WDR7
|
WD repeat domain 7
|
-3.71052
|
|
LDHD
|
lactate dehydrogenase D
|
-3.67132
|
|
KDM3A
|
lysine (K)-specific demethylase 3A
|
-3.54359
|
|
PECR
|
peroxisomal trans-2-enoyl-CoA reductase
|
-3.41902
|
|
MRPS2
|
mitochondrial ribosomal protein S2
|
-3.40079
|
|
TSEN2
|
TSEN2 tRNA splicing endonuclease subunit
|
-2.88811
|
|
HYOU1
|
hypoxia up-regulated 1
|
-2.82309
|
|
EIF5
|
eukaryotic translation initiation factor 5
|
-2.73791
|
|
HMG20B
|
high mobility group 20B
|
-2.51175
|
|
ASAH1
|
N-acylsphingosine amidohydrolase (acid ceramidase) 1
|
-2.48261
|
|
PAEP
|
progestagen-associated endometrial protein
|
-2.293
|
|
DCK
|
deoxycytidine kinase
|
-2.26371
|
|
MAP4K4
|
mitogen-activated protein kinase kinase kinase kinase 4
|
-2.23539
|
