CRCGN010_HEPG2_24H:L20 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description sulfuric acid compound with 2-methyl-1,4-benzenediamine (1:1) 10.44 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

131 genes differentially expressed following the CRCGN010_HEPG2_24H:L20 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CXCL2 chemokine (C-X-C motif) ligand 2 6.81151
LCN2 lipocalin 2 6.58089
TXNRD1 thioredoxin reductase 1 6.431
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 4.62877
PPARG peroxisome proliferator-activated receptor gamma 4.62616
MVP major vault protein 4.47839
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 4.38416
GPER1 G protein-coupled estrogen receptor 1 4.31659
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase) 4.17981
GSTZ1 glutathione S-transferase zeta 1 3.97451
CYCS cytochrome c, somatic 3.9161
UGDH UDP-glucose 6-dehydrogenase 3.88631
SQOR sulfide quinone oxidoreductase 3.77221
GPATCH8 G patch domain containing 8 3.72098
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) 3.69752
CGRRF1 cell growth regulator with ring finger domain 1 3.58859
ABHD4 abhydrolase domain containing 4 3.48884
CBR3 carbonyl reductase 3 3.45746
NANOS3 nanos homolog 3 (Drosophila) 3.45094
INPP1 inositol polyphosphate-1-phosphatase 3.3872
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 3.28648
BZW2 basic leucine zipper and W2 domains 2 3.27701
CRYZ crystallin, zeta (quinone reductase) 3.18436
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 3.15699
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 3.13367
RAP1GAP RAP1 GTPase activating protein 3.08428
CEMIP2 cell migration inducing hyaluronidase 2 3.04
CSK c-src tyrosine kinase 2.98133
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 2.97549
ACOT9 acyl-CoA thioesterase 9 2.93042
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 2.91564
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 2.89366
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 2.83124
BDH1 3-hydroxybutyrate dehydrogenase, type 1 2.8105
EVL Enah/Vasp-like 2.78777
ZFP36 ZFP36 ring finger protein 2.74138
MAMLD1 mastermind-like domain containing 1 2.73646
HLA-DRA major histocompatibility complex, class II, DR alpha 2.73462
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 2.72393
FOSL1 FOS-like antigen 1 2.68344
TBP TATA box binding protein 2.6813
KIFBP kinesin family binding protein 2.62447
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 2.60017
SLC75A1 solute carrier family 75 member 1 2.56538
SQSTM1 sequestosome 1 2.56413
NENF neudesin neurotrophic factor 2.5537
RALB v-ral simian leukemia viral oncogene homolog B 2.46989
PIH1D1 PIH1 domain containing 1 2.43387
SNAP25 synaptosomal-associated protein, 25kDa 2.41257
INTS3 integrator complex subunit 3 2.38439
CCDC86 coiled-coil domain containing 86 2.30519
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 2.29823
DUSP6 dual specificity phosphatase 6 2.23606
AXIN1 axin 1 2.20302
PCDHB11 protocadherin beta 11 2.18591
BAG2 BCL2-associated athanogene 2 2.18149
SLC41A3 solute carrier family 41, member 3 2.16618
MNAT1 MNAT CDK-activating kinase assembly factor 1 2.15157
CA14 carbonic anhydrase XIV 2.13171
STARD8 StAR-related lipid transfer (START) domain containing 8 2.11685
EPS8 epidermal growth factor receptor pathway substrate 8 2.11303
MYC v-myc avian myelocytomatosis viral oncogene homolog 2.10377
NPDC1 neural proliferation, differentiation and control, 1 2.09082
MAST2 microtubule associated serine/threonine kinase 2 2.07712
ATF3 activating transcription factor 3 2.07541
CAB39 calcium binding protein 39 2.07046
TJAP1 tight junction associated protein 1 (peripheral) 2.06305
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 2.04101
SLC25A46 solute carrier family 25, member 46 2.03355
PLS1 plastin 1 2.03016
NOP14 NOP14 nucleolar protein 2.02065

decreased expression

Symbol Name Standardized Value
PCNA proliferating cell nuclear antigen -6.72343
GNAS GNAS complex locus -4.53106
PUF60 poly-U binding splicing factor 60KDa -3.93636
CCNB2 cyclin B2 -3.88098
TMEM109 transmembrane protein 109 -3.80723
CASP3 caspase 3, apoptosis-related cysteine peptidase -3.79969
ZNF586 zinc finger protein 586 -3.70431
TSEN2 TSEN2 tRNA splicing endonuclease subunit -3.46726
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -3.43903
RPS4Y1 ribosomal protein S4, Y-linked 1 -3.41911
CCNB1 cyclin B1 -3.40617
HYOU1 hypoxia up-regulated 1 -3.40177
FGFR4 fibroblast growth factor receptor 4 -3.3763
DCK deoxycytidine kinase -3.3708
ITFG1 integrin alpha FG-GAP repeat containing 1 -3.35663
USP6NL USP6 N-terminal like -3.32695
RNASE7 ribonuclease, RNase A family, 7 -3.13196
PSRC1 proline/serine-rich coiled-coil 1 -3.08493
SNX11 sorting nexin 11 -3.05797
TLR4 toll-like receptor 4 -3.04671
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.92764
AURKB aurora kinase B -2.83645
TCERG1 transcription elongation regulator 1 -2.82897
DNMT1 DNA (cytosine-5-)-methyltransferase 1 -2.80386
SCRIB scribbled planar cell polarity protein -2.79292
STMN1 stathmin 1 -2.77207
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -2.76931
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -2.76761
WDR7 WD repeat domain 7 -2.72199
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -2.69064
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -2.68755
EPB41L2 erythrocyte membrane protein band 4.1-like 2 -2.62169
ZNF274 zinc finger protein 274 -2.58862
TYW2 tRNA wybutosine-synthesizing protein 2 -2.54514
ALDOC aldolase C, fructose-bisphosphate -2.51499
ACAA1 acetyl-CoA acyltransferase 1 -2.37476
ERBB2 erb-b2 receptor tyrosine kinase 2 -2.32666
POLR1A polymerase (RNA) I polypeptide A, 194kDa -2.31894
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B -2.28512
MSH6 mutS homolog 6 -2.2819
MTA1 metastasis associated 1 -2.27721
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 -2.26659
ZNF804A zinc finger protein 804A -2.25967
KLHDC2 kelch domain containing 2 -2.23561
LOC124907782 dual specificity protein phosphatase 22 -2.22471
ZNF16 zinc finger protein 16 -2.20036
NT5DC2 5'-nucleotidase domain containing 2 -2.18752
PLA2G15 phospholipase A2, group XV -2.1839
PGM1 phosphoglucomutase 1 -2.17234
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -2.12862
CSTF1 cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa -2.11546
ANKEF1 ankyrin repeat and EF-hand domain containing 1 -2.10758
EXOSC4 exosome component 4 -2.07393
PEG10 paternally expressed 10 -2.07351
SESN1 sestrin 1 -2.0712
TM9SF2 transmembrane 9 superfamily member 2 -2.06394
SYNE2 spectrin repeat containing, nuclear envelope 2 -2.04307
XPO7 exportin 7 -2.03279
UPF2 UPF2 regulator of nonsense transcripts homolog (yeast) -2.01056
CENPU centromere protein U -2.01046