| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | sulfuric acid compound with 2-methyl-1,4-benzenediamine (1:1) 5.22 um perturbation at 24 h in HEPG2 (Carcinogenome) |
| Similar Terms | |
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73 genes differentially expressed following the CRCGN010_HEPG2_24H:L21 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MAP7 | microtubule-associated protein 7 | 7.90938 |
| CXCL2 | chemokine (C-X-C motif) ligand 2 | 6.88644 |
| ST3GAL5 | ST3 beta-galactoside alpha-2,3-sialyltransferase 5 | 6.83863 |
| CHN1 | chimerin 1 | 5.19531 |
| NOL3 | nucleolar protein 3 (apoptosis repressor with CARD domain) | 5.17739 |
| UGDH | UDP-glucose 6-dehydrogenase | 4.11449 |
| MVP | major vault protein | 3.9517 |
| DHX29 | DEAH (Asp-Glu-Ala-His) box polypeptide 29 | 3.84362 |
| TXNRD1 | thioredoxin reductase 1 | 3.79529 |
| CSK | c-src tyrosine kinase | 3.59429 |
| TIMM22 | translocase of inner mitochondrial membrane 22 homolog (yeast) | 3.58869 |
| ABCB6 | ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) | 3.40409 |
| RAP1GAP | RAP1 GTPase activating protein | 3.39076 |
| GPATCH8 | G patch domain containing 8 | 3.21907 |
| CASP2 | caspase 2, apoptosis-related cysteine peptidase | 3.13662 |
| NUDT9 | nudix (nucleoside diphosphate linked moiety X)-type motif 9 | 3.06551 |
| CHEK2 | checkpoint kinase 2 | 3.06425 |
| ABCC5 | ATP-binding cassette, sub-family C (CFTR/MRP), member 5 | 3.02323 |
| HLA-DRA | major histocompatibility complex, class II, DR alpha | 2.96023 |
| CIAO3 | cytosolic iron-sulfur assembly component 3 | 2.75298 |
| NOTCH1 | notch 1 | 2.73847 |
| SATB1 | SATB homeobox 1 | 2.71897 |
| SNAP25 | synaptosomal-associated protein, 25kDa | 2.69287 |
| EVL | Enah/Vasp-like | 2.66445 |
| MYC | v-myc avian myelocytomatosis viral oncogene homolog | 2.6542 |
| KEAP1 | kelch-like ECH-associated protein 1 | 2.61835 |
| NANOS3 | nanos homolog 3 (Drosophila) | 2.58567 |
| TBC1D19 | TBC1 domain family, member 19 | 2.46486 |
| KCNK1 | potassium channel, two pore domain subfamily K, member 1 | 2.29873 |
| NIT2 | nitrilase family, member 2 | 2.25206 |
| TEX10 | testis expressed 10 | 2.20794 |
| CDC25B | cell division cycle 25B | 2.20234 |
| TIAM1 | T-cell lymphoma invasion and metastasis 1 | 2.1851 |
| HMOX1 | heme oxygenase 1 | 2.14717 |
| MTERF3 | mitochondrial transcription termination factor 3 | 2.14694 |
| HLA-DMA | major histocompatibility complex, class II, DM alpha | 2.1419 |
| SLC15A2 | solute carrier family 15 (oligopeptide transporter), member 2 | 2.11652 |
| CRYZ | crystallin, zeta (quinone reductase) | 2.05117 |
| TRIM16 | tripartite motif containing 16 | 2.05112 |
| BAX | BCL2-associated X protein | 2.0235 |
| Symbol | Name | Standardized Value |
|---|---|---|
| OXA1L | oxidase (cytochrome c) assembly 1-like | -4.52869 |
| GOLT1B | golgi transport 1B | -3.55499 |
| IARS2 | isoleucyl-tRNA synthetase 2, mitochondrial | -3.35989 |
| DNAJA3 | DnaJ (Hsp40) homolog, subfamily A, member 3 | -3.24703 |
| KDM3A | lysine (K)-specific demethylase 3A | -3.24628 |
| CCNB2 | cyclin B2 | -3.21743 |
| COG2 | component of oligomeric golgi complex 2 | -3.20675 |
| SLC7A5 | solute carrier family 7 (amino acid transporter light chain, L system), member 5 | -3.16737 |
| FBXL12 | F-box and leucine-rich repeat protein 12 | -3.10839 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -3.07006 |
| HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase | -3.05546 |
| CCDC86 | coiled-coil domain containing 86 | -3.04338 |
| MYL9 | myosin, light chain 9, regulatory | -2.92003 |
| HYOU1 | hypoxia up-regulated 1 | -2.91669 |
| TCTN1 | tectonic family member 1 | -2.75046 |
| ERBB2 | erb-b2 receptor tyrosine kinase 2 | -2.7482 |
| TLR4 | toll-like receptor 4 | -2.64112 |
| DSG2 | desmoglein 2 | -2.45646 |
| AURKB | aurora kinase B | -2.44761 |
| EDN1 | endothelin 1 | -2.44206 |
| TSEN2 | TSEN2 tRNA splicing endonuclease subunit | -2.34792 |
| NGRN | neugrin, neurite outgrowth associated | -2.34558 |
| PEG10 | paternally expressed 10 | -2.3317 |
| PPP2R5E | protein phosphatase 2, regulatory subunit B', epsilon isoform | -2.30587 |
| CRK | v-crk avian sarcoma virus CT10 oncogene homolog | -2.25385 |
| CAB39 | calcium binding protein 39 | -2.24822 |
| S100A4 | S100 calcium binding protein A4 | -2.13941 |
| SLC26A6 | solute carrier family 26 (anion exchanger), member 6 | -2.12616 |
| EIF5 | eukaryotic translation initiation factor 5 | -2.10254 |
| YIPF5 | Yip1 domain family, member 5 | -2.07045 |
| ZNF557 | zinc finger protein 557 | -2.04966 |
| GNAS | GNAS complex locus | -2.02306 |
| HTR2B | 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled | -2.01008 |
