| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | sulfuric acid compound with 2-methyl-1,4-benzenediamine (1:1) 2.61 um perturbation at 24 h in HEPG2 (Carcinogenome) |
| Similar Terms | |
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68 genes differentially expressed following the CRCGN010_HEPG2_24H:L22 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 6.44213 |
| MNAT1 | MNAT CDK-activating kinase assembly factor 1 | 4.63244 |
| GPER1 | G protein-coupled estrogen receptor 1 | 4.55548 |
| CXCL2 | chemokine (C-X-C motif) ligand 2 | 3.92194 |
| IKBKE | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon | 3.75463 |
| CHMP6 | charged multivesicular body protein 6 | 3.71755 |
| ABCC5 | ATP-binding cassette, sub-family C (CFTR/MRP), member 5 | 3.66893 |
| CARMIL1 | capping protein regulator and myosin 1 linker 1 | 3.58702 |
| CIAO3 | cytosolic iron-sulfur assembly component 3 | 3.5714 |
| CSK | c-src tyrosine kinase | 3.47465 |
| IDE | insulin-degrading enzyme | 3.45394 |
| CYCS | cytochrome c, somatic | 3.42801 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 3.3433 |
| MAP7 | microtubule-associated protein 7 | 3.19829 |
| JADE2 | jade family PHD finger 2 | 3.18491 |
| NUDT9 | nudix (nucleoside diphosphate linked moiety X)-type motif 9 | 3.0935 |
| CDPF1 | cysteine-rich, DPF motif domain containing 1 | 3.01021 |
| LOC122526780 | uncharacterized LOC122526780 | 3.00672 |
| AMDHD2 | amidohydrolase domain containing 2 | 2.93801 |
| VAT1 | vesicle amine transport 1 | 2.87179 |
| PSMB8 | proteasome (prosome, macropain) subunit, beta type, 8 | 2.60468 |
| GATA2 | GATA binding protein 2 | 2.5461 |
| MVP | major vault protein | 2.29862 |
| P4HTM | prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) | 2.27951 |
| TXNRD1 | thioredoxin reductase 1 | 2.25284 |
| SLC38A6 | solute carrier family 38, member 6 | 2.21579 |
| SMARCD2 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 | 2.21153 |
| ICAM1 | intercellular adhesion molecule 1 | 2.19698 |
| HERC6 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 | 2.19607 |
| STIMATE | STIM activating enhancer | 2.17108 |
| CDK19 | cyclin-dependent kinase 19 | 2.12085 |
| CDK6 | cyclin-dependent kinase 6 | 2.04217 |
| GPATCH8 | G patch domain containing 8 | 2.03089 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CCNB2 | cyclin B2 | -7.52285 |
| CASP7 | caspase 7, apoptosis-related cysteine peptidase | -4.9425 |
| ADI1 | acireductone dioxygenase 1 | -4.21331 |
| GTPBP8 | GTP-binding protein 8 (putative) | -3.78913 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | -3.77021 |
| LDHD | lactate dehydrogenase D | -3.73696 |
| SLC35F2 | solute carrier family 35, member F2 | -3.61505 |
| SNX11 | sorting nexin 11 | -3.57928 |
| HMG20B | high mobility group 20B | -3.38443 |
| RAI14 | retinoic acid induced 14 | -3.04918 |
| LSM5 | LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) | -3.02787 |
| TSEN2 | TSEN2 tRNA splicing endonuclease subunit | -3.01639 |
| GNAS | GNAS complex locus | -2.8581 |
| DNAJA3 | DnaJ (Hsp40) homolog, subfamily A, member 3 | -2.79981 |
| CDC25B | cell division cycle 25B | -2.75045 |
| EIF5 | eukaryotic translation initiation factor 5 | -2.74619 |
| KDM3A | lysine (K)-specific demethylase 3A | -2.73953 |
| CHIC2 | cysteine-rich hydrophobic domain 2 | -2.7113 |
| RNF167 | ring finger protein 167 | -2.70774 |
| NRIP1 | nuclear receptor interacting protein 1 | -2.59202 |
| PKIG | protein kinase (cAMP-dependent, catalytic) inhibitor gamma | -2.48419 |
| VDAC1 | voltage-dependent anion channel 1 | -2.41564 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | -2.40851 |
| MRPS2 | mitochondrial ribosomal protein S2 | -2.35645 |
| IARS2 | isoleucyl-tRNA synthetase 2, mitochondrial | -2.35028 |
| PPOX | protoporphyrinogen oxidase | -2.33862 |
| HSD17B11 | hydroxysteroid (17-beta) dehydrogenase 11 | -2.29847 |
| DNM1L | dynamin 1-like | -2.22065 |
| ATP6V1D | ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D | -2.21819 |
| NPTXR | neuronal pentraxin receptor | -2.16945 |
| SETD6 | SET domain containing 6 | -2.16046 |
| FAM13B | family with sequence similarity 13, member B | -2.12614 |
| AP2S1 | adaptor-related protein complex 2, sigma 1 subunit | -2.12555 |
| ATP5ME | ATP synthase membrane subunit e | -2.07799 |
| C5 | complement component 5 | -2.07501 |
