CRCGN010_HEPG2_24H:L23 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description sulfuric acid compound with 2-methyl-1,4-benzenediamine (1:1) 1.31 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

101 genes differentially expressed following the CRCGN010_HEPG2_24H:L23 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PPARG peroxisome proliferator-activated receptor gamma 9.28291
RPL39L ribosomal protein L39-like 7.73549
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 6.43714
LYN LYN proto-oncogene, Src family tyrosine kinase 5.57085
MOK MOK protein kinase 4.59595
BTK Bruton agammaglobulinemia tyrosine kinase 4.33751
CHMP6 charged multivesicular body protein 6 3.95775
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 3.76754
CHN1 chimerin 1 3.70363
TATDN2 TatD DNase domain containing 2 3.63971
MINDY1 MINDY lysine 48 deubiquitinase 1 3.63188
AMDHD2 amidohydrolase domain containing 2 3.55561
SATB1 SATB homeobox 1 3.3712
TREM1 triggering receptor expressed on myeloid cells 1 3.23223
EAPP E2F-associated phosphoprotein 3.15602
JADE2 jade family PHD finger 2 3.04054
ADO 2-aminoethanethiol (cysteamine) dioxygenase 3.02875
BATF3 basic leucine zipper transcription factor, ATF-like 3 2.99233
TIAM1 T-cell lymphoma invasion and metastasis 1 2.97218
HLA-DMA major histocompatibility complex, class II, DM alpha 2.93182
E2F2 E2F transcription factor 2 2.75272
VAT1 vesicle amine transport 1 2.73877
LY86 lymphocyte antigen 86 2.58447
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.52377
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.51476
GAA glucosidase, alpha; acid 2.49062
NOSIP nitric oxide synthase interacting protein 2.47828
HMOX1 heme oxygenase 1 2.45692
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 2.38699
STIMATE STIM activating enhancer 2.30996
RPP38 ribonuclease P/MRP 38kDa subunit 2.30976
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 2.27023
BNIP1 BCL2/adenovirus E1B 19kDa interacting protein 1 2.26228
RAB20 RAB20, member RAS oncogene family 2.25216
CD80 CD80 molecule 2.23505
VAV1 vav 1 guanine nucleotide exchange factor 2.20801
DOCK2 dedicator of cytokinesis 2 2.20661
PRKCH protein kinase C, eta 2.16101
ZNF552 zinc finger protein 552 2.15375
COPZ1 coatomer protein complex, subunit zeta 1 2.15319
CD33 CD33 molecule 2.12883
UST uronyl-2-sulfotransferase 2.11718
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 2.11114
PLSCR3 phospholipid scramblase 3 2.10274
LPAR2 lysophosphatidic acid receptor 2 2.07154
NFU1 NFU1 iron-sulfur cluster scaffold 2.06696
PPP1R17 protein phosphatase 1, regulatory subunit 17 2.05642
PEX11A peroxisomal biogenesis factor 11 alpha 2.05033
MTMR11 myotubularin related protein 11 2.04282
CAMTA2 calmodulin binding transcription activator 2 2.03548
WDR4 WD repeat domain 4 2.03311
PLCD1 phospholipase C, delta 1 2.03183
IRAK4 interleukin-1 receptor-associated kinase 4 2.02979
DIPK1A divergent protein kinase domain 1A 2.02967
TAOK3 TAO kinase 3 2.02645
FSD1 fibronectin type III and SPRY domain containing 1 2.0217
RFC4 replication factor C (activator 1) 4, 37kDa 2.00802

decreased expression

Symbol Name Standardized Value
GNAS GNAS complex locus -6.99801
OXA1L oxidase (cytochrome c) assembly 1-like -6.75784
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -6.19602
PEG10 paternally expressed 10 -4.65604
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -4.50203
COG7 component of oligomeric golgi complex 7 -4.23155
NISCH nischarin -4.10952
KDM3A lysine (K)-specific demethylase 3A -4.04591
GTPBP8 GTP-binding protein 8 (putative) -3.87501
MRPS2 mitochondrial ribosomal protein S2 -3.84384
CD320 CD320 molecule -3.82349
HSPB1 heat shock 27kDa protein 1 -3.73197
TLCD3A TLC domain containing 3A -3.70209
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase -3.51948
CCNB2 cyclin B2 -3.50139
MAPK13 mitogen-activated protein kinase 13 -3.47448
EIF5 eukaryotic translation initiation factor 5 -3.31959
SMNDC1 survival motor neuron domain containing 1 -3.10092
PRPF4 pre-mRNA processing factor 4 -3.08129
CCNB1 cyclin B1 -3.03537
CRELD2 cysteine-rich with EGF-like domains 2 -3.01408
PPOX protoporphyrinogen oxidase -2.87759
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.77432
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -2.61738
ZNF514 zinc finger protein 514 -2.60719
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.5883
AHCY adenosylhomocysteinase -2.45788
MAP9 microtubule-associated protein 9 -2.44007
BAZ2B bromodomain adjacent to zinc finger domain, 2B -2.3922
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase -2.38329
GOLT1A golgi transport 1A -2.37648
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -2.31302
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -2.30214
LUC7L LUC7-like (S. cerevisiae) -2.27346
NRIP1 nuclear receptor interacting protein 1 -2.26574
DNAJC10 DnaJ (Hsp40) homolog, subfamily C, member 10 -2.22901
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 -2.1806
GOLGA6L9 golgin A6 family-like 9 -2.13793
ITFG1 integrin alpha FG-GAP repeat containing 1 -2.13314
TTBK2 tau tubulin kinase 2 -2.08053
CDK5R2 cyclin-dependent kinase 5, regulatory subunit 2 (p39) -2.07534
SLC25A3 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3 -2.0534
CCDC181 coiled-coil domain containing 181 -2.04935
RAI14 retinoic acid induced 14 -2.04297