CRCGN010_HEPG2_24H:L24 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description sulfuric acid compound with 2-methyl-1,4-benzenediamine (1:1) 0.65 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

47 genes differentially expressed following the CRCGN010_HEPG2_24H:L24 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 8.31683
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 6.11958
LOC122526780 uncharacterized LOC122526780 4.31915
SKIC2 SKI2 subunit of superkiller complex 4.17503
BPHL biphenyl hydrolase-like (serine hydrolase) 4.08406
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase) 4.02603
FRS2 fibroblast growth factor receptor substrate 2 3.9381
CNPY3 canopy FGF signaling regulator 3 3.03796
STAP2 signal transducing adaptor family member 2 3.03621
PYGL phosphorylase, glycogen, liver 2.93297
BTK Bruton agammaglobulinemia tyrosine kinase 2.81729
CSK c-src tyrosine kinase 2.72817
CCL2 chemokine (C-C motif) ligand 2 2.50896
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.48422
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 2.44843
GATA2 GATA binding protein 2 2.38821
PRUNE1 prune exopolyphosphatase 1 2.3768
ZNF589 zinc finger protein 589 2.32936
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) 2.30324
GPC1 glypican 1 2.26783
MCM3 minichromosome maintenance complex component 3 2.24205
EGF epidermal growth factor 2.19971
CEP57 centrosomal protein 57kDa 2.183
LOC124904942 uncharacterized LOC124904942 2.17268
EGFL8 EGF-like-domain, multiple 8 2.15625
SCYL3 SCY1-like 3 (S. cerevisiae) 2.07891
HLA-DMA major histocompatibility complex, class II, DM alpha 2.07416
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 2.01116
MYLK myosin light chain kinase 2.00532

decreased expression

Symbol Name Standardized Value
TLR4 toll-like receptor 4 -7.13643
ACOT9 acyl-CoA thioesterase 9 -5.07202
CD320 CD320 molecule -4.55818
WASHC4 WASH complex subunit 4 -3.53647
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -3.13913
DDIT4 DNA-damage-inducible transcript 4 -3.04578
CAB39 calcium binding protein 39 -2.98967
TOR1A torsin family 1, member A (torsin A) -2.94548
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -2.93289
CCNB2 cyclin B2 -2.93011
FBXL12 F-box and leucine-rich repeat protein 12 -2.83991
HYOU1 hypoxia up-regulated 1 -2.74626
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -2.5478
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -2.38029
PDLIM1 PDZ and LIM domain 1 -2.22913
SNX11 sorting nexin 11 -2.17153
VDAC1 voltage-dependent anion channel 1 -2.06369
TUBB6 tubulin, beta 6 class V -2.04169