CRCGN010_HEPG2_24H:M13 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description isoniazid 40.2 um perturbation at 24 h in HEPG2 (Carcinogenome)
Similar Terms
Downloads & Tools

Genes

293 genes differentially expressed following the CRCGN010_HEPG2_24H:M13 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 9.24425
MAP7 microtubule-associated protein 7 7.6782
ANO10 anoctamin 10 6.05445
PPARG peroxisome proliferator-activated receptor gamma 5.76615
NOTCH1 notch 1 5.46605
RPP38 ribonuclease P/MRP 38kDa subunit 5.45605
RPL39L ribosomal protein L39-like 5.45255
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 5.3313
CSK c-src tyrosine kinase 5.22685
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) 5.1473
CYCS cytochrome c, somatic 5.1411
LCN2 lipocalin 2 5.0
PPP1R13B protein phosphatase 1, regulatory subunit 13B 4.9205
AXIN1 axin 1 4.82345
HDGFL3 HDGF like 3 4.79844
CBR3 carbonyl reductase 3 4.7717
MINDY1 MINDY lysine 48 deubiquitinase 1 4.75395
E2F2 E2F transcription factor 2 4.5974
CIAO3 cytosolic iron-sulfur assembly component 3 4.59395
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 4.494
LSR lipolysis stimulated lipoprotein receptor 4.3898
GATA3 GATA binding protein 3 4.3864
CCL2 chemokine (C-C motif) ligand 2 4.30435
DYNLT3 dynein, light chain, Tctex-type 3 4.165
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.13425
CXCL2 chemokine (C-X-C motif) ligand 2 4.09295
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 3.98585
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) 3.9073
ZFP36 ZFP36 ring finger protein 3.79135
OXCT1 3-oxoacid CoA transferase 1 3.5623
TAC4 tachykinin 4 (hemokinin) 3.51225
EPN2 epsin 2 3.47035
JADE2 jade family PHD finger 2 3.42097
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 3.4126
BAALC brain and acute leukemia, cytoplasmic 3.39925
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 3.31708
ADGRG1 adhesion G protein-coupled receptor G1 3.31362
GPER1 G protein-coupled estrogen receptor 1 3.26562
MRPL42 mitochondrial ribosomal protein L42 3.1671
ZBTB35 zinc finger and BTB domain containing 35 3.06737
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 3.01515
INSIG1 insulin induced gene 1 3.01187
TBXA2R thromboxane A2 receptor 2.99402
SLC14A1 solute carrier family 14 (urea transporter), member 1 (Kidd blood group) 2.8443
GRB10 growth factor receptor-bound protein 10 2.80458
PLBD1 phospholipase B domain containing 1 2.77245
NPRL3 nitrogen permease regulator-like 3 (S. cerevisiae) 2.77108
HLA-DRA major histocompatibility complex, class II, DR alpha 2.74753
TIAM1 T-cell lymphoma invasion and metastasis 1 2.73992
THAP11 THAP domain containing 11 2.73585
CGGBP1 CGG triplet repeat binding protein 1 2.70975
CAVIN2 caveolae associated protein 2 2.6654
UPK1A uroplakin 1A 2.64545
TRH thyrotropin-releasing hormone 2.63235
EGF epidermal growth factor 2.6185
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma 2.61395
SCAND1 SCAN domain containing 1 2.609
CHN1 chimerin 1 2.5904
GSK3B glycogen synthase kinase 3 beta 2.57195
CEL carboxyl ester lipase 2.5655
FZD7 frizzled class receptor 7 2.55495
PTX3 pentraxin 3, long 2.5305
NXPH3 neurexophilin 3 2.5064
EAPP E2F-associated phosphoprotein 2.5042
ANGPT1 angiopoietin 1 2.49102
LYPD3 LY6/PLAUR domain containing 3 2.47715
ECM1 extracellular matrix protein 1 2.45075
TJP2 tight junction protein 2 2.44475
SLC22A11 solute carrier family 22 (organic anion/urate transporter), member 11 2.43905
GRWD1 glutamate-rich WD repeat containing 1 2.4349
F13A1 coagulation factor XIII, A1 polypeptide 2.4128
TNIP1 TNFAIP3 interacting protein 1 2.41015
EPHA3 EPH receptor A3 2.40088
RALY RALY heterogeneous nuclear ribonucleoprotein 2.3919
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 2.39055
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15 2.38827
SLC6A12 solute carrier family 6 (neurotransmitter transporter), member 12 2.385
TMPRSS11E transmembrane protease, serine 11E 2.35975
CCNH cyclin H 2.3597
GLTP glycolipid transfer protein 2.35645
SPRR3 small proline-rich protein 3 2.348
PARP1 poly (ADP-ribose) polymerase 1 2.3457
MSX2 msh homeobox 2 2.33157
UBA7 ubiquitin-like modifier activating enzyme 7 2.31848
TFE3 transcription factor binding to IGHM enhancer 3 2.3171
SHMT1 serine hydroxymethyltransferase 1 (soluble) 2.31565
NCOA4 nuclear receptor coactivator 4 2.3123
LRP2 low density lipoprotein receptor-related protein 2 2.3072
MAPK7 mitogen-activated protein kinase 7 2.30512
MTERF3 mitochondrial transcription termination factor 3 2.29825
ACY1 aminoacylase 1 2.2972
ECD ecdysoneless homolog (Drosophila) 2.288
AP1B1 adaptor-related protein complex 1, beta 1 subunit 2.28725
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide 2.27715
CRTAP cartilage associated protein 2.2721
RAP2C RAP2C, member of RAS oncogene family 2.2679
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.24805
SH2D4A SH2 domain containing 4A 2.23145
P2RX1 purinergic receptor P2X, ligand gated ion channel, 1 2.2208
CCNE2 cyclin E2 2.21035
NKX2-5 NK2 homeobox 5 2.2052
TEX10 testis expressed 10 2.1919
ALDH3B2 aldehyde dehydrogenase 3 family, member B2 2.1886
CCNK cyclin K 2.18705
EFHD2 EF-hand domain family, member D2 2.1834
DCK deoxycytidine kinase 2.1826
ALDOB aldolase B, fructose-bisphosphate 2.18021
BLVRB biliverdin reductase B 2.17645
SETMAR SET domain and mariner transposase fusion gene 2.15625
DNASE1 deoxyribonuclease I 2.1555
ACE2 angiotensin I converting enzyme 2 2.1537
RAB26 RAB26, member RAS oncogene family 2.15365
NEBL nebulette 2.15193
OLIG2 oligodendrocyte lineage transcription factor 2 2.14932
PER1 period circadian clock 1 2.1486
PPP4R1 protein phosphatase 4, regulatory subunit 1 2.1444
ZNF35 zinc finger protein 35 2.14355
ZNF764 zinc finger protein 764 2.14175
ORMDL2 ORMDL sphingolipid biosynthesis regulator 2 2.14115
SDF2 stromal cell-derived factor 2 2.1398
RTN4 reticulon 4 2.13342
EHD3 EH-domain containing 3 2.131
SYTL2 synaptotagmin-like 2 2.12685
TMUB2 transmembrane and ubiquitin-like domain containing 2 2.12055
RAB25 RAB25, member RAS oncogene family 2.1205
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1 2.11485
ITGA9 integrin, alpha 9 2.1124
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6 2.11125
RHBG Rh family, B glycoprotein (gene/pseudogene) 2.1105
HAT1 histone acetyltransferase 1 2.10825
TGM3 transglutaminase 3 2.1057
POLDIP2 polymerase (DNA-directed), delta interacting protein 2 2.10565
PRR15L proline rich 15-like 2.1054
FAR2 fatty acyl CoA reductase 2 2.1033
STAU2 staufen double-stranded RNA binding protein 2 2.10235
SRGN serglycin 2.09955
DKK1 dickkopf WNT signaling pathway inhibitor 1 2.098
TTI2 TELO2 interacting protein 2 2.09765
ENDOU endonuclease, polyU-specific 2.09515
CT55 cancer/testis antigen 55 2.0948
SNED1 sushi, nidogen and EGF-like domains 1 2.09433
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 2.0942
MEPCE methylphosphate capping enzyme 2.08325
ECHDC3 enoyl CoA hydratase domain containing 3 2.08265
TRPM3 transient receptor potential cation channel, subfamily M, member 3 2.0825
RBM10 RNA binding motif protein 10 2.07272
ZNF747 zinc finger protein 747 2.0691
ZNF84 zinc finger protein 84 2.0647
DGKI diacylglycerol kinase, iota 2.061
S100A2 S100 calcium binding protein A2 2.0609
HMOX1 heme oxygenase 1 2.05335
RAP1GAP2 RAP1 GTPase activating protein 2 2.0489
RHOT2 ras homolog family member T2 2.04162
DAO D-amino-acid oxidase 2.0398
TRPS1 trichorhinophalangeal syndrome I 2.03415
AAR2 AAR2 splicing factor homolog (S. cerevisiae) 2.0309
SSTR4 somatostatin receptor 4 2.024
SMAGP small cell adhesion glycoprotein 2.02335
REPS2 RALBP1 associated Eps domain containing 2 2.02275
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa 2.02195
UPK2 uroplakin 2 2.02
ABHD5 abhydrolase domain containing 5 2.01787
TMEM39B transmembrane protein 39B 2.01615
ITPKC inositol-trisphosphate 3-kinase C 2.01505
CTRL chymotrypsin-like 2.012
PXMP2 peroxisomal membrane protein 2, 22kDa 2.01198
MCL1 myeloid cell leukemia 1 2.0108
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein 2.01075
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 2.01075
ACSS3 acyl-CoA synthetase short-chain family member 3 2.0075
GREB1L growth regulation by estrogen in breast cancer-like 2.00695
COX6B1 cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous) 2.00625
PDE7B phosphodiesterase 7B 2.0041

decreased expression

Symbol Name Standardized Value
PCNA proliferating cell nuclear antigen -10.0
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -10.0
OXA1L oxidase (cytochrome c) assembly 1-like -7.0534
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -6.0839
TRIB3 tribbles pseudokinase 3 -5.59825
NGRN neugrin, neurite outgrowth associated -5.45375
CHMP4B charged multivesicular body protein 4B -5.25863
KDM3A lysine (K)-specific demethylase 3A -4.9234
KTN1 kinectin 1 (kinesin receptor) -4.9211
LOC124907782 dual specificity protein phosphatase 22 -4.7946
ADI1 acireductone dioxygenase 1 -4.7316
CCNB2 cyclin B2 -4.53725
RPN1 ribophorin I -4.5289
B4GAT1 beta-1,4-glucuronyltransferase 1 -4.4603
PLK1 polo-like kinase 1 -4.45135
CCNB1 cyclin B1 -4.42165
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -4.3971
CASP3 caspase 3, apoptosis-related cysteine peptidase -4.15805
TLCD3A TLC domain containing 3A -3.99135
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa -3.8565
HYOU1 hypoxia up-regulated 1 -3.85125
CASP7 caspase 7, apoptosis-related cysteine peptidase -3.8489
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 -3.77175
PRPF4 pre-mRNA processing factor 4 -3.723
SYNE2 spectrin repeat containing, nuclear envelope 2 -3.58965
RFC2 replication factor C (activator 1) 2, 40kDa -3.52945
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) -3.48232
CAB39 calcium binding protein 39 -3.28285
PPOX protoporphyrinogen oxidase -3.0799
MAPK13 mitogen-activated protein kinase 13 -2.99773
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -2.97485
SUMF2 sulfatase modifying factor 2 -2.9328
CPNE3 copine III -2.9047
PLA1A phospholipase A1 member A -2.8861
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -2.81285
COL9A2 collagen, type IX, alpha 2 -2.7581
RTN3 reticulon 3 -2.7057
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -2.68275
ATG16L1 autophagy related 16-like 1 (S. cerevisiae) -2.63425
SQSTM1 sequestosome 1 -2.6034
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -2.6011
CHEK1 checkpoint kinase 1 -2.53627
SATB1 SATB homeobox 1 -2.53155
ACAA1 acetyl-CoA acyltransferase 1 -2.52297
TIGAR TP53 induced glycolysis regulatory phosphatase -2.5167
TRIM44 tripartite motif containing 44 -2.51518
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.5134
FBXO7 F-box protein 7 -2.50255
RNPEP arginyl aminopeptidase (aminopeptidase B) -2.49887
RAI14 retinoic acid induced 14 -2.48365
KLHDC3 kelch domain containing 3 -2.479
TGFB2 transforming growth factor, beta 2 -2.46195
FKBP3 FK506 binding protein 3, 25kDa -2.42485
DCAF6 DDB1 and CUL4 associated factor 6 -2.4131
STT3A STT3A, subunit of the oligosaccharyltransferase complex (catalytic) -2.4124
CLIP2 CAP-GLY domain containing linker protein 2 -2.36115
WDR46 WD repeat domain 46 -2.36105
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5 -2.35395
SHB Src homology 2 domain containing adaptor protein B -2.3535
COPG1 coatomer protein complex, subunit gamma 1 -2.35075
ADORA2B adenosine A2b receptor -2.33715
DEGS1 delta(4)-desaturase, sphingolipid 1 -2.31685
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.31662
TIMCC TIM double twin CX3C motif chaperone -2.3139
PLAAT3 phospholipase A and acyltransferase 3 -2.31095
KCTD14 potassium channel tetramerization domain containing 14 -2.31065
KDELR1 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 -2.30115
TICAM1 toll-like receptor adaptor molecule 1 -2.2935
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1) -2.2924
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) -2.28195
TSPAN14 tetraspanin 14 -2.26195
SSR1 signal sequence receptor, alpha -2.24964
STEAP3 STEAP family member 3, metalloreductase -2.2428
NEO1 neogenin 1 -2.2418
MYC v-myc avian myelocytomatosis viral oncogene homolog -2.2374
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3 -2.2352
B4GALT3 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3 -2.23205
DDTL D-dopachrome tautomerase-like -2.21885
DDRGK1 DDRGK domain containing 1 -2.21785
SMC4 structural maintenance of chromosomes 4 -2.20482
NAA16 N(alpha)-acetyltransferase 16, NatA auxiliary subunit -2.20395
GTPBP8 GTP-binding protein 8 (putative) -2.1956
ATG14 autophagy related 14 -2.195
TMEM214 transmembrane protein 214 -2.19355
RSU1 Ras suppressor protein 1 -2.1919
RBP1 retinol binding protein 1, cellular -2.1884
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 -2.1791
NAT10 N-acetyltransferase 10 (GCN5-related) -2.16975
B4GALT2 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2 -2.1694
TESK2 testis-specific kinase 2 -2.1688
SMIM29 small integral membrane protein 29 -2.16785
ARHGAP17 Rho GTPase activating protein 17 -2.16595
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 -2.16385
NME3 NME/NM23 nucleoside diphosphate kinase 3 -2.15915
ALG8 ALG8, alpha-1,3-glucosyltransferase -2.15785
KIF14 kinesin family member 14 -2.15055
PLCXD1 phosphatidylinositol-specific phospholipase C, X domain containing 1 -2.13335
CYBA cytochrome b-245, alpha polypeptide -2.12175
KLHL21 kelch-like family member 21 -2.11645
NXF3 nuclear RNA export factor 3 -2.1045
RTCA RNA 3'-terminal phosphate cyclase -2.0933
SSRP1 structure specific recognition protein 1 -2.0862
ZNF74 zinc finger protein 74 -2.0834
RNF144A ring finger protein 144A -2.07635
CSTF3 cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa -2.07295
HOXD1 homeobox D1 -2.07195
GTF2F2 general transcription factor IIF, polypeptide 2, 30kDa -2.0674
SAC3D1 SAC3 domain containing 1 -2.06735
SDHAF3 succinate dehydrogenase complex assembly factor 3 -2.04115
COL17A1 collagen, type XVII, alpha 1 -2.041
RRP9 ribosomal RNA processing 9, small subunit (SSU) processome component, homolog (yeast) -2.0407
LRRC8D leucine rich repeat containing 8 family, member D -2.03245
SLC23A1 solute carrier family 23 (ascorbic acid transporter), member 1 -2.02233
TFRC transferrin receptor -2.02045
ATP8A2 ATPase, aminophospholipid transporter, class I, type 8A, member 2 -2.00973
SIGMAR1 sigma non-opioid intracellular receptor 1 -2.00885
BLMH bleomycin hydrolase -2.00845
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.00755
ADAP2 ArfGAP with dual PH domains 2 -2.00575
SOX12 SRY (sex determining region Y)-box 12 -2.0035