CRCGN010_HEPG2_24H:M17 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description isoniazid 2.51 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

78 genes differentially expressed following the CRCGN010_HEPG2_24H:M17 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 10.0
CYCS cytochrome c, somatic 5.91649
CHN1 chimerin 1 5.57022
GSTZ1 glutathione S-transferase zeta 1 5.24491
CBR3 carbonyl reductase 3 4.2303
MINDY1 MINDY lysine 48 deubiquitinase 1 4.08153
RPL39L ribosomal protein L39-like 3.87753
JADE2 jade family PHD finger 2 3.60997
CSK c-src tyrosine kinase 3.60026
HOXA10 homeobox A10 3.46571
ABHD6 abhydrolase domain containing 6 3.35869
ADGRE5 adhesion G protein-coupled receptor E5 3.2829
HLA-DRA major histocompatibility complex, class II, DR alpha 3.21745
MAP7 microtubule-associated protein 7 3.06973
PPARG peroxisome proliferator-activated receptor gamma 2.99902
NOTCH1 notch 1 2.94372
DYNLT3 dynein, light chain, Tctex-type 3 2.91853
CHMP6 charged multivesicular body protein 6 2.77296
RRAGA Ras-related GTP binding A 2.70118
FPGS folylpolyglutamate synthase 2.50326
FZD7 frizzled class receptor 7 2.47708
PRR15L proline rich 15-like 2.42678
PEX11A peroxisomal biogenesis factor 11 alpha 2.39061
ZFP36 ZFP36 ring finger protein 2.35023
KDM5A lysine (K)-specific demethylase 5A 2.28826
ANKMY2 ankyrin repeat and MYND domain containing 2 2.24291
MAGEF1 melanoma antigen family F1 2.17565
HOOK2 hook microtubule-tethering protein 2 2.12163
PRPF39 pre-mRNA processing factor 39 2.11494
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit 2.09552
DNA2 DNA replication helicase/nuclease 2 2.04134

decreased expression

Symbol Name Standardized Value
CCNB2 cyclin B2 -9.53232
LDHD lactate dehydrogenase D -7.66421
VAT1 vesicle amine transport 1 -7.58998
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -5.96938
TLR4 toll-like receptor 4 -5.77263
CCDC86 coiled-coil domain containing 86 -4.81703
ADI1 acireductone dioxygenase 1 -4.57449
SLC35F2 solute carrier family 35, member F2 -4.24448
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -4.1793
NT5DC2 5'-nucleotidase domain containing 2 -4.03801
DNM1L dynamin 1-like -3.96001
DHRS7 dehydrogenase/reductase (SDR family) member 7 -3.75057
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.3726
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -3.27103
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -3.0423
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -2.97566
ZNF586 zinc finger protein 586 -2.83556
NGRN neugrin, neurite outgrowth associated -2.77952
GNAS GNAS complex locus -2.7698
SNX11 sorting nexin 11 -2.74031
SMNDC1 survival motor neuron domain containing 1 -2.63607
ARID5B AT rich interactive domain 5B (MRF1-like) -2.61514
HEATR1 HEAT repeat containing 1 -2.47078
SAP130 Sin3A-associated protein, 130kDa -2.42054
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -2.29005
SYP synaptophysin -2.27694
DEPP1 DEPP autophagy regulator 1 -2.27058
CD58 CD58 molecule -2.2551
GRIK4 glutamate receptor, ionotropic, kainate 4 -2.25391
IDO1 indoleamine 2,3-dioxygenase 1 -2.1877
MAPK13 mitogen-activated protein kinase 13 -2.18768
CAPN5 calpain 5 -2.182
EPHB6 EPH receptor B6 -2.1589
GPR37L1 G protein-coupled receptor 37 like 1 -2.15266
KDM3A lysine (K)-specific demethylase 3A -2.11854
DERA deoxyribose-phosphate aldolase (putative) -2.11136
SNTG2 syntrophin, gamma 2 -2.10679
TIMELESS timeless circadian clock -2.09624
TXNDC9 thioredoxin domain containing 9 -2.08876
CBX2 chromobox homolog 2 -2.07876
INSM1 insulinoma-associated 1 -2.07669
SIGLEC5 sialic acid binding Ig-like lectin 5 -2.05941
AP3B2 adaptor-related protein complex 3, beta 2 subunit -2.05939
HYOU1 hypoxia up-regulated 1 -2.0579
MS4A2 membrane-spanning 4-domains, subfamily A, member 2 -2.0297
ST7L suppression of tumorigenicity 7 like -2.00798
ZDHHC6 zinc finger, DHHC-type containing 6 -2.00527