CRCGN010_HEPG2_24H:M23 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description iodoform 2.5 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

53 genes differentially expressed following the CRCGN010_HEPG2_24H:M23 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
E2F2 E2F transcription factor 2 5.26615
CSK c-src tyrosine kinase 5.2594
RPL39L ribosomal protein L39-like 5.22401
LCN2 lipocalin 2 4.99461
TIAM1 T-cell lymphoma invasion and metastasis 1 4.55981
LYN LYN proto-oncogene, Src family tyrosine kinase 4.25936
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 3.99571
ABHD6 abhydrolase domain containing 6 3.9638
PEX11A peroxisomal biogenesis factor 11 alpha 3.96008
PNKP polynucleotide kinase 3'-phosphatase 3.76263
CHMP6 charged multivesicular body protein 6 3.75202
KLHL9 kelch-like family member 9 3.70101
ADRB2 adrenoceptor beta 2, surface 3.63999
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 3.31309
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 3.27391
RPP38 ribonuclease P/MRP 38kDa subunit 3.11711
HLA-DMA major histocompatibility complex, class II, DM alpha 3.04737
HSPA1A heat shock 70kDa protein 1A 2.78218
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 2.76556
DIPK1A divergent protein kinase domain 1A 2.43652
H2BC12 H2B clustered histone 12 2.38318
PPP2R5A protein phosphatase 2, regulatory subunit B', alpha 2.37446
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 2.3696
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.33576
TNIP1 TNFAIP3 interacting protein 1 2.32152
LPAR2 lysophosphatidic acid receptor 2 2.26931
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.18685
DOCK5 dedicator of cytokinesis 5 2.17945
CHN1 chimerin 1 2.08317
NKAIN1 Na+/K+ transporting ATPase interacting 1 2.05168
WIPF2 WAS/WASL interacting protein family, member 2 2.02653
IPO13 importin 13 2.0132

decreased expression

Symbol Name Standardized Value
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -6.05514
OXA1L oxidase (cytochrome c) assembly 1-like -5.05228
KDM3A lysine (K)-specific demethylase 3A -5.00783
PCCB propionyl CoA carboxylase, beta polypeptide -4.91681
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -4.4542
PECR peroxisomal trans-2-enoyl-CoA reductase -3.67694
LDHD lactate dehydrogenase D -3.65485
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -3.54615
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.53503
FBXL12 F-box and leucine-rich repeat protein 12 -3.51283
PROS1 protein S (alpha) -3.33486
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.61466
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) -2.60879
TXNRD1 thioredoxin reductase 1 -2.48652
TXNDC9 thioredoxin domain containing 9 -2.4295
MPC2 mitochondrial pyruvate carrier 2 -2.33963
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -2.33562
CRELD2 cysteine-rich with EGF-like domains 2 -2.30906
APEH acylaminoacyl-peptide hydrolase -2.28232
MAPK13 mitogen-activated protein kinase 13 -2.0704
TMEM115 transmembrane protein 115 -2.00363