CRCGN010_HEPG2_24H:M24 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description iodoform 1.25 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

54 genes differentially expressed following the CRCGN010_HEPG2_24H:M24 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
AMDHD2 amidohydrolase domain containing 2 7.66551
TREM1 triggering receptor expressed on myeloid cells 1 5.56049
CHN1 chimerin 1 5.40173
NR1H2 nuclear receptor subfamily 1, group H, member 2 5.01491
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.75386
GSTZ1 glutathione S-transferase zeta 1 4.55611
ZNF589 zinc finger protein 589 4.52588
SFTPB surfactant protein B 3.77561
CCNF cyclin F 3.40878
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 3.2552
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.99608
DYNLT3 dynein, light chain, Tctex-type 3 2.93788
CXCL2 chemokine (C-X-C motif) ligand 2 2.91487
RXYLT1 ribitol xylosyltransferase 1 2.81043
MAST2 microtubule associated serine/threonine kinase 2 2.6203
PLSCR3 phospholipid scramblase 3 2.61585
CYCS cytochrome c, somatic 2.4924
MOK MOK protein kinase 2.45823
MNMIP1 manchette microtubule inner protein 1 2.42049
LSR lipolysis stimulated lipoprotein receptor 2.40722
MAP7 microtubule-associated protein 7 2.30353
GPER1 G protein-coupled estrogen receptor 1 2.20256
ANO1 anoctamin 1, calcium activated chloride channel 2.1948
TRIM2 tripartite motif containing 2 2.15085
MELK maternal embryonic leucine zipper kinase 2.0809
COL3A1 collagen, type III, alpha 1 2.03673
ADGRE5 adhesion G protein-coupled receptor E5 2.02655
CHMP6 charged multivesicular body protein 6 2.00074

decreased expression

Symbol Name Standardized Value
TARBP1 TAR (HIV-1) RNA binding protein 1 -5.95596
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -5.28522
HACD3 3-hydroxyacyl-CoA dehydratase 3 -5.20394
TSEN2 TSEN2 tRNA splicing endonuclease subunit -5.02719
CCNB2 cyclin B2 -4.97902
THAP11 THAP domain containing 11 -4.86008
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa -4.47721
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -4.30646
ZMIZ1 zinc finger, MIZ-type containing 1 -2.97559
ARID5B AT rich interactive domain 5B (MRF1-like) -2.86763
OXA1L oxidase (cytochrome c) assembly 1-like -2.51204
TLCD3A TLC domain containing 3A -2.47499
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 -2.43826
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -2.43446
CCNB1 cyclin B1 -2.41797
FAIM Fas apoptotic inhibitory molecule -2.39552
USP6NL USP6 N-terminal like -2.37516
KDM3A lysine (K)-specific demethylase 3A -2.35085
CDC25B cell division cycle 25B -2.27735
RNF167 ring finger protein 167 -2.2564
ICAM3 intercellular adhesion molecule 3 -2.24845
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -2.21592
DDIT4 DNA-damage-inducible transcript 4 -2.19277
HSPB1 heat shock 27kDa protein 1 -2.12195
TRIB3 tribbles pseudokinase 3 -2.10885
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.01147