| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | dimethylnitrosamine 9.95 um perturbation at 24 h in HEPG2 (Carcinogenome) |
| Similar Terms | |
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135 genes differentially expressed following the CRCGN010_HEPG2_24H:N03 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CHMP6 | charged multivesicular body protein 6 | 9.80379 |
| AMDHD2 | amidohydrolase domain containing 2 | 8.6968 |
| DYNLT3 | dynein, light chain, Tctex-type 3 | 8.21078 |
| MAPKAPK5 | mitogen-activated protein kinase-activated protein kinase 5 | 5.53439 |
| LOC122526780 | uncharacterized LOC122526780 | 4.7859 |
| CSK | c-src tyrosine kinase | 4.71304 |
| CHN1 | chimerin 1 | 4.68825 |
| DIPK1A | divergent protein kinase domain 1A | 4.5838 |
| NOTCH1 | notch 1 | 4.52527 |
| GSTZ1 | glutathione S-transferase zeta 1 | 4.40839 |
| DNAJB2 | DnaJ (Hsp40) homolog, subfamily B, member 2 | 4.39551 |
| CYCS | cytochrome c, somatic | 4.31958 |
| TIMM22 | translocase of inner mitochondrial membrane 22 homolog (yeast) | 4.10809 |
| GFOD1 | glucose-fructose oxidoreductase domain containing 1 | 4.09651 |
| HLA-DMA | major histocompatibility complex, class II, DM alpha | 4.05613 |
| MAMLD1 | mastermind-like domain containing 1 | 3.91315 |
| TIAM1 | T-cell lymphoma invasion and metastasis 1 | 3.8907 |
| CPSF4 | cleavage and polyadenylation specific factor 4, 30kDa | 3.84748 |
| CTSL | cathepsin L | 3.83238 |
| MYLK | myosin light chain kinase | 3.64517 |
| PHKG2 | phosphorylase kinase, gamma 2 (testis) | 3.61732 |
| NT5DC2 | 5'-nucleotidase domain containing 2 | 3.30195 |
| CEBPZ | CCAAT/enhancer binding protein (C/EBP), zeta | 3.27292 |
| PDLIM1 | PDZ and LIM domain 1 | 3.2697 |
| IDE | insulin-degrading enzyme | 3.26624 |
| MICALL1 | MICAL-like 1 | 3.15953 |
| SFTPB | surfactant protein B | 3.14481 |
| ZNF274 | zinc finger protein 274 | 3.02953 |
| CCDC86 | coiled-coil domain containing 86 | 2.89248 |
| PLEKHJ1 | pleckstrin homology domain containing, family J member 1 | 2.75994 |
| MICAL3 | microtubule associated monooxygenase, calponin and LIM domain containing 3 | 2.71215 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 2.6896 |
| DDX42 | DEAD (Asp-Glu-Ala-Asp) box helicase 42 | 2.67637 |
| TBX2 | T-box 2 | 2.53622 |
| VPS45 | vacuolar protein sorting 45 homolog (S. cerevisiae) | 2.53554 |
| TGFBR2 | transforming growth factor, beta receptor II (70/80kDa) | 2.4744 |
| ENPP2 | ectonucleotide pyrophosphatase/phosphodiesterase 2 | 2.4271 |
| CASP3 | caspase 3, apoptosis-related cysteine peptidase | 2.36238 |
| CASC3 | cancer susceptibility candidate 3 | 2.3623 |
| GSAP | gamma-secretase activating protein | 2.323 |
| GSTA4 | glutathione S-transferase alpha 4 | 2.28632 |
| TRAP1 | TNF receptor-associated protein 1 | 2.27788 |
| FIS1 | fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) | 2.26815 |
| NIPSNAP1 | nipsnap homolog 1 (C. elegans) | 2.25973 |
| IL36RN | interleukin 36 receptor antagonist | 2.25177 |
| PMM2 | phosphomannomutase 2 | 2.24745 |
| DNM1L | dynamin 1-like | 2.24542 |
| ARMCX4 | armadillo repeat containing, X-linked 4 | 2.23031 |
| VGLL3 | vestigial-like family member 3 | 2.22818 |
| HSPA8 | heat shock 70kDa protein 8 | 2.2272 |
| PLCB3 | phospholipase C, beta 3 (phosphatidylinositol-specific) | 2.22492 |
| TTC21B | tetratricopeptide repeat domain 21B | 2.21986 |
| MSRA | methionine sulfoxide reductase A | 2.215 |
| STX4 | syntaxin 4 | 2.20217 |
| BUB1B | BUB1 mitotic checkpoint serine/threonine kinase B | 2.19523 |
| FBXO40 | F-box protein 40 | 2.15185 |
| PCBD1 | pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha | 2.13809 |
| NISCH | nischarin | 2.12391 |
| ATP6V1E1 | ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1 | 2.10029 |
| SOCS2 | suppressor of cytokine signaling 2 | 2.07238 |
| SRC | SRC proto-oncogene, non-receptor tyrosine kinase | 2.06211 |
| CDC25B | cell division cycle 25B | 2.05981 |
| INPP5F | inositol polyphosphate-5-phosphatase F | 2.05808 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 2.0234 |
| ABCF1 | ATP-binding cassette, sub-family F (GCN20), member 1 | 2.01733 |
| MAP3K4 | mitogen-activated protein kinase kinase kinase 4 | 2.00306 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PKIG | protein kinase (cAMP-dependent, catalytic) inhibitor gamma | -6.65463 |
| SLC35F2 | solute carrier family 35, member F2 | -6.41669 |
| GOLT1B | golgi transport 1B | -6.05287 |
| CDKN1B | cyclin-dependent kinase inhibitor 1B (p27, Kip1) | -5.88671 |
| CCNB2 | cyclin B2 | -5.81062 |
| SCAND1 | SCAN domain containing 1 | -5.35619 |
| HSD17B11 | hydroxysteroid (17-beta) dehydrogenase 11 | -5.31882 |
| TM9SF2 | transmembrane 9 superfamily member 2 | -4.58225 |
| IARS2 | isoleucyl-tRNA synthetase 2, mitochondrial | -4.55203 |
| ZW10 | zw10 kinetochore protein | -4.39848 |
| TLR4 | toll-like receptor 4 | -4.36975 |
| CDC20 | cell division cycle 20 | -4.25024 |
| LDHD | lactate dehydrogenase D | -4.05891 |
| TARBP1 | TAR (HIV-1) RNA binding protein 1 | -3.65773 |
| PPP2R3C | protein phosphatase 2, regulatory subunit B'', gamma | -3.62367 |
| CHEK1 | checkpoint kinase 1 | -3.61712 |
| DDIT4 | DNA-damage-inducible transcript 4 | -3.52329 |
| CCNB1 | cyclin B1 | -3.40987 |
| RFC2 | replication factor C (activator 1) 2, 40kDa | -3.40598 |
| LSM6 | LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) | -3.32503 |
| AGL | amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase | -3.20116 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | -3.15247 |
| HAT1 | histone acetyltransferase 1 | -3.13389 |
| PRCP | prolylcarboxypeptidase (angiotensinase C) | -3.09155 |
| CAB39 | calcium binding protein 39 | -3.07645 |
| NUP93 | nucleoporin 93kDa | -3.06019 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | -3.05907 |
| EAPP | E2F-associated phosphoprotein | -2.98131 |
| MTFR1 | mitochondrial fission regulator 1 | -2.97157 |
| XPNPEP1 | X-prolyl aminopeptidase (aminopeptidase P) 1, soluble | -2.84147 |
| NR2F6 | nuclear receptor subfamily 2, group F, member 6 | -2.79319 |
| THAP11 | THAP domain containing 11 | -2.76658 |
| ADI1 | acireductone dioxygenase 1 | -2.73299 |
| CNDP2 | CNDP dipeptidase 2 (metallopeptidase M20 family) | -2.69896 |
| SQOR | sulfide quinone oxidoreductase | -2.65324 |
| SLC35A3 | solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 | -2.65316 |
| HSPA1A | heat shock 70kDa protein 1A | -2.65156 |
| CCNH | cyclin H | -2.59929 |
| ANXA7 | annexin A7 | -2.56882 |
| PTPN1 | protein tyrosine phosphatase, non-receptor type 1 | -2.56643 |
| GLOD4 | glyoxalase domain containing 4 | -2.47709 |
| TBPL1 | TBP-like 1 | -2.46947 |
| G3BP1 | GTPase activating protein (SH3 domain) binding protein 1 | -2.46885 |
| GNAS | GNAS complex locus | -2.41322 |
| UBE2C | ubiquitin-conjugating enzyme E2C | -2.39133 |
| TM9SF3 | transmembrane 9 superfamily member 3 | -2.38169 |
| UBQLN2 | ubiquilin 2 | -2.37519 |
| ZNF586 | zinc finger protein 586 | -2.37052 |
| PSMG1 | proteasome (prosome, macropain) assembly chaperone 1 | -2.34666 |
| RRP12 | ribosomal RNA processing 12 homolog (S. cerevisiae) | -2.32932 |
| ELAC2 | elaC ribonuclease Z 2 | -2.28171 |
| HYOU1 | hypoxia up-regulated 1 | -2.24889 |
| CRYZ | crystallin, zeta (quinone reductase) | -2.24466 |
| MYBL2 | v-myb avian myeloblastosis viral oncogene homolog-like 2 | -2.21486 |
| KIFBP | kinesin family binding protein | -2.20516 |
| NGRN | neugrin, neurite outgrowth associated | -2.19313 |
| ISOC1 | isochorismatase domain containing 1 | -2.17832 |
| ENOPH1 | enolase-phosphatase 1 | -2.17025 |
| TCERG1 | transcription elongation regulator 1 | -2.15124 |
| ANXA1 | annexin A1 | -2.14464 |
| RXYLT1 | ribitol xylosyltransferase 1 | -2.11219 |
| RAB21 | RAB21, member RAS oncogene family | -2.11047 |
| PSMB10 | proteasome (prosome, macropain) subunit, beta type, 10 | -2.09184 |
| ITGB1BP1 | integrin beta 1 binding protein 1 | -2.08101 |
| CTDSP1 | CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1 | -2.05858 |
| HACD3 | 3-hydroxyacyl-CoA dehydratase 3 | -2.05343 |
| CARMIL1 | capping protein regulator and myosin 1 linker 1 | -2.03897 |
| CAPN1 | calpain 1, (mu/I) large subunit | -2.03693 |
| RUVBL1 | RuvB-like AAA ATPase 1 | -2.02433 |
