CRCGN010_HEPG2_24H:N07 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description vinyl toluene 39.6 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

99 genes differentially expressed following the CRCGN010_HEPG2_24H:N07 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 8.54737
PPARG peroxisome proliferator-activated receptor gamma 8.34812
CHMP6 charged multivesicular body protein 6 7.54336
ATP11B ATPase, class VI, type 11B 6.1631
LCN2 lipocalin 2 6.03381
NOTCH1 notch 1 4.95836
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 4.67056
MYLK myosin light chain kinase 4.34092
TATDN2 TatD DNase domain containing 2 4.31349
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 4.13711
E2F2 E2F transcription factor 2 4.1237
SNAP25 synaptosomal-associated protein, 25kDa 4.03829
GSTZ1 glutathione S-transferase zeta 1 4.00693
ADGRE5 adhesion G protein-coupled receptor E5 3.64107
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 3.58208
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 3.51247
TIAM1 T-cell lymphoma invasion and metastasis 1 3.49659
RPP38 ribonuclease P/MRP 38kDa subunit 3.31451
ABHD6 abhydrolase domain containing 6 3.26989
MEST mesoderm specific transcript 3.18028
TREM1 triggering receptor expressed on myeloid cells 1 3.03931
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.98384
TEX10 testis expressed 10 2.9266
GPER1 G protein-coupled estrogen receptor 1 2.92314
HLA-DRA major histocompatibility complex, class II, DR alpha 2.89259
PNKP polynucleotide kinase 3'-phosphatase 2.86545
PTK2 protein tyrosine kinase 2 2.7143
FPGS folylpolyglutamate synthase 2.60797
CEP57 centrosomal protein 57kDa 2.60277
CCNF cyclin F 2.47747
MAST2 microtubule associated serine/threonine kinase 2 2.42281
EGF epidermal growth factor 2.39785
CD40 CD40 molecule, TNF receptor superfamily member 5 2.33884
STARD3 StAR-related lipid transfer (START) domain containing 3 2.32219
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 2.21899
LTA lymphotoxin alpha 2.20448
PRH1 proline-rich protein HaeIII subfamily 1 2.17318
SLC16A8 solute carrier family 16 (monocarboxylate transporter), member 8 2.15758
CHUK conserved helix-loop-helix ubiquitous kinase 2.1501
SSTR5 somatostatin receptor 5 2.13659
PARL presenilin associated, rhomboid-like 2.12898
COL15A1 collagen, type XV, alpha 1 2.12561
TCFL5 transcription factor-like 5 (basic helix-loop-helix) 2.10607
FCHO1 FCH domain only 1 2.09848
GPATCH8 G patch domain containing 8 2.08974
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 2.07994
NECTIN4 nectin cell adhesion molecule 4 2.07822
PGCKA1 PDCD10 and GCKIII kinases associated 1 2.06368
AKTIP AKT interacting protein 2.05872
EEF1A2 eukaryotic translation elongation factor 1 alpha 2 2.05624
GNB1L guanine nucleotide binding protein (G protein), beta polypeptide 1-like 2.03395
YRDC yrdC N(6)-threonylcarbamoyltransferase domain containing 2.03208
CATSPERH catsper channel auxiliary subunit eta 2.0189
CBX6 chromobox homolog 6 2.01503
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta 2.00376
PSMD3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 2.00268

decreased expression

Symbol Name Standardized Value
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -7.46692
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -6.40997
KDM3A lysine (K)-specific demethylase 3A -6.36699
ENOPH1 enolase-phosphatase 1 -5.31767
ADI1 acireductone dioxygenase 1 -4.93462
NT5DC2 5'-nucleotidase domain containing 2 -4.91873
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -4.82706
CDC20 cell division cycle 20 -4.77383
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -4.59966
NUP85 nucleoporin 85kDa -4.52671
TUBB6 tubulin, beta 6 class V -4.41023
ZNF586 zinc finger protein 586 -4.40357
CHMP4B charged multivesicular body protein 4B -4.37155
VDAC1 voltage-dependent anion channel 1 -4.15682
TLCD3A TLC domain containing 3A -3.64637
GLOD4 glyoxalase domain containing 4 -3.55663
GNAS GNAS complex locus -3.55656
CCDC86 coiled-coil domain containing 86 -3.51172
LYPLA1 lysophospholipase I -3.49025
MRPL58 mitochondrial ribosomal protein L58 -3.11532
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 -2.89837
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -2.71978
FGFR4 fibroblast growth factor receptor 4 -2.65957
ARID5B AT rich interactive domain 5B (MRF1-like) -2.63203
NGRN neugrin, neurite outgrowth associated -2.6282
C2CD5 C2 calcium-dependent domain containing 5 -2.59845
STAMBP STAM binding protein -2.5495
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.53788
LAP3 leucine aminopeptidase 3 -2.5248
CTNND1 catenin (cadherin-associated protein), delta 1 -2.50095
NRIP1 nuclear receptor interacting protein 1 -2.49805
MGRN1 mahogunin ring finger 1, E3 ubiquitin protein ligase -2.48787
KCTD2 potassium channel tetramerization domain containing 2 -2.34426
MRPS7 mitochondrial ribosomal protein S7 -2.3057
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1 -2.2847
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -2.1947
GRB2 growth factor receptor-bound protein 2 -2.19063
PRPF4 pre-mRNA processing factor 4 -2.12189
CTSV cathepsin V -2.06109
CCDC6 coiled-coil domain containing 6 -2.05506
PMS2 PMS2 postmeiotic segregation increased 2 (S. cerevisiae) -2.0352
WBP2 WW domain binding protein 2 -2.02042
MORC2 MORC family CW-type zinc finger 2 -2.00901